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Myeloid Cells in Health and Disease: A Synthesis
![Myeloid Cells in Health and Disease: A Synthesis](http://img.images-bn.com/static/redesign/srcs/images/grey-box.png?v11.9.4)
Myeloid Cells in Health and Disease: A Synthesis
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Overview
In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including
- the recruitment of myeloid and other immune cells following microbial infection
- the role of myeloid cells in the inflammation process and the repair of damaged tissue
- the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin
- receptors and downstream signaling pathways that are activated following ligand-receptor binding
- roles of myeloid cells during microbial and parasite infections
- contributions of myeloid cells in atherosclerosis
- myeloid-derived suppressor cells in tumor development and cancer
Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.
Table of Contents
ContributorsPreface
Acknowledgments
About the Editor
Section I Introduction and History
1 Paul Ehrlich and the Early History of GranulocytesA. Barry Kay
2 The Phagocyte, Metchnikoff, and the Foundation of ImmunologyGiuseppe Teti, Carmelo Biondo, and Concetta Beninati
3 Growth and Differentiation FactorsDonald Metcalf and Nicos A. Nicola
Section II General Aspects
4 Evolution of Myeloid CellsDaniel R. Barreda, Harold R. Neely, and Martin F. Flajnik
5 Advances on Myeloid Like-Cell Origins and Functions in the Model Organism Drosophila melanogasterLaure El Chamy, Nicolas Matt, and Jean-Marc Reichhart
6 Monocyte, Macrophage, and Dendritic Cell Development: the Human PerspectiveMatthew Collin and Venetia Bigley
7 Myeloid Cell Turnover and ClearanceWilliam J. Janssen, Donna L. Bratton, Claudia V. Jakubzick, and Peter M. Henson
Section III Specialization
8 Transcriptional Regulation and Macrophage DifferentiationDavid A. Hume, Kim M. Summers, and Michael Rehli
9 Murine Monocytes: Origins, Subsets, Fates, and FunctionsAlexander Mildner, Goran Marinkovic, and Steffen Jung
10 Dendritic Cells in the Immune System—History, Lineages, Tissues, Tolerance, and ImmunityJonathan M. Austyn
11 Antigen Processing and Presentation Mechanisms in Myeloid CellsPaul A. Roche and Peter Cresswell
12 MicrogliaV. Hugh Perry
13 Osteoclasts—Key Players in Skeletal Health and DiseaseDeborah Veis Novack and Gabriel Mbalaviele
14 The Regulatory Function of EosinophilsTing Wen and Marc E. Rothenberg
Section IV Recruitment, Inflammation, and Repair
15 Intravital Imaging of Myeloid Cells: Inflammatory Migration and Resident PatrollingJustin F. Deniset and Paul Kubes
16 Multifaceted Functions of NOD-Like Receptor Proteins in Myeloid Cells at the Intersection of Innate and Adaptive ImmunityThomas A. Kufer, Giulia Nigro, and Philippe J. Sansonetti
17 Inflammasomes in Myeloid Cells: Warriors Within Sushmita Jha and Jenny Pan-Yun Ting
18 Inflammation—a Critical Appreciation of the Role of Myeloid CellsAsif J. Iqbal, Edward A. Fisher, and David R. Greaves
19 Lipid Mediators in InflammationMelanie Bennett and Derek W. Gilroy
20 Macrophage Proresolving Mediators—the When and WhereJesmond Dalli and Charles Serhan
21 Myeloid Cells in Cutaneous Wound RepairJenna L. Cash and Paul Martin
Section V Recognition, Signaling, and Gene Expression
22 The Role and Function of Fcγ Receptors on Myeloid CellsStylianos Bournazos, Taia T. Wang, and Jeffrey V. Ravetch
23 Complement Receptors in Myeloid Cell Adhesion and PhagocytosisMichael L. Dustin
24 Toll-Like Receptor Signaling and Its Inducible ProteinsTakashi Satoh and Shizuo Akira
25 Lectin Receptors Expressed on Myeloid CellsGordon D. Brown and Paul R. Crocker
26 G Protein-Coupled Receptors in MacrophagesHsi-Hsien Lin and Martin Stacey
27 Molecular Mechanisms of Phagosome FormationValentin Jaumouillé and Sergio Grinstein
28 Role of the Cytoskeleton in Myeloid Cell FunctionNoah Fine, Samira Khaliq, Siavash Hassanpour, and Michael Glogauer
29 Coordinated Regulation of Signaling Pathways during Macrophage ActivationToby Lawrence
30 Genome-Wide Approaches to Defining Macrophage Identity and FunctionGregory J. Fonseca, Jason S. Seidman, and Christopher K. Glass
31 Epigenetic Regulation of Myeloid CellsLionel B. Ivashkiv and Sung Ho Park
Section VI Secretion and Defense
32 Secretion from Myeloid Cells: Secretory LysosomesGillian M. Griffiths
33 The NADPH Oxidase and Microbial Killing by Neutrophils, With a Particular Emphasis on the Proposed Antimicrobial Role of Myeloperoxidase within the Phagocytic VacuoleAdam P. Levine and Anthony W. Segal
34 Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune CellsRyan G. Gaudet, Clinton J. Bradfield, and John D. MacMicking
35 Anti-TNF TherapyIrina Udalova, Claudia Monaco, Jagdeep Nanchahal, and Marc Feldmann
36 Metalloproteinases: a Functional Pathway for Myeloid CellsJonathan Chou, Matilda F. Chan, and Zena Werb
Section VII Immunoregulation and Infection
37 Interplay between Myeloid Cells and Humoral Innate ImmunitySébastien Jaillon, Eduardo Bonavita, Cecilia Garlanda, and Alberto Mantovani
38 Adaptive Characteristics of Innate Immune Responses in MacrophagesRob J. W. Arts and Mihai G. Netea
39 Intestinal Mononuclear Phagocytes in Health and DiseaseTheodore J. Sanders, Ulf Yrlid, and Kevin J. Maloy
40 Strategies Used by Bacteria to Grow in MacrophagesGabriel Mitchell, Chen Chen, and Daniel A. Portnoy
41 Mechanisms of Defense against Intracellular Pathogens Mediated by Human MacrophagesBarry R. Bloom and Robert L. Modlin
42 Myeloid Cells in AsthmaBart N. Lambrecht, Emma Persson, and Hamida Hammad
43 Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite InfectionsRick M. Maizels and James P. Hewitson
44 Induction of Immunological Tolerance as a Therapeutic ProcedureHerman Waldmann, Duncan Howie, and Stephen Cobbold
Section VIII Metabolic and Malignant Disease
45 Glutathione and Glutathione Transferase Omega 1 as Key Post-Translational Regulators in MacrophagesMark M. Hughes, Anne F. McGettrick, and Luke A.J. O'Neill
46 Macrophages and Iron MetabolismTomas Ganz
47 Mechanisms of Myeloid Cell Modulation of AtherosclerosisFilip K. Swirski, Matthias Nahrendorf, and Peter Libby
48 Macrophages in Endocrine Glands with Emphasis on Pancreatic IsletsEmil R. Unanue
59 Tumor-Induced Myeloid-Derived Suppressor CellsFrancesco De Sanctis, Vincenzo Bronte, and Stefano Ugel
50 Myeloid Cell Origins, Differentiation, and Clinical ImplicationsKipp Weiskopf, Peter J. Schnorr, Wendy W. Pang, Mark P. Chao, Akanksha Chhabra, Jun Seita, Mingye Feng, and Irving L. Weissman
Index