Myeloid-Derived Suppressor Cells

by Carlos Jiménez-Cortegana (Editor), Lorenzo Galluzzi (Editor)

Overview

Myeloid-Derived Suppressor Cells, Volume 375 includes comprehensive and detailed reviews on the current advances in myeloid derived suppressor cells, an immature, heterogenous cell population from the myeloid lineage that has been extensively described in the last decades due to its potent immunosuppressive activity in a variety of pathologies. Chapters in this new release include Cancer-cell-intrinsic mechanisms regulate myeloid-derived suppressor cells through cytokine networks, Role of myeloid-derived suppressor cells in head and neck cancer, Role of myeloid-derived suppressor cells in breast cancer, Role of myeloid-derived suppressor cells in endometriosis, Role of myeloid-derived suppressor cells in ovarian cancer, Role of myeloid-derived suppressor cells in sarcoma, and more.

Product Details

ISBN-13:	9780443218071
Publisher:	Elsevier Science
Publication date:	03/19/2024
Series:	Methods in Cell Biology , #184
Pages:	318
Product dimensions:	7.50(w) x 9.25(h) x (d)

About the Author

Carlos Jiménez-Cortegana obtained the degree in Chemistry at University of Seville (Spain) in 2014. In July 2020 he got the PhD in Clinical Research at the same University, belonging to the group headed by Dr. Luis de la Cruz-Merino and Dr. Víctor Sánchez-Margalet. Currently, Carlos is a Postdoctoral Researcher at the Department of Radiation Oncology, Weill Cornell Medical College (New York, USA), in the research group headed by Dr. Lorenzo Galluzzi. From 2021, Carlos has published more than 15 articles in recognized, international journals, some of them in high-impact factor journals, mainly focused on the immunosuppressive role of myeloid-derived suppressor cells in a variety of diseases, including breast cancer, diffuse large B-cell lymphoma, and COVID-19.

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.

Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

Table of Contents

1. Detection of myeloid-derived suppressor cells by flow cytometry
Tianju Liu
2. Determination of murine myeloid-derived suppressor cells by flow cytometry
Hiroshi Kitamura
3. Isolation of Myeloid-Derived Suppressor Cells (MDSC) from Endometriotic Mice Model and their Immunomodulatory Functions
Gene Man
4. Simple protocol for measuring CD11b+ GR-1+ (Ly6C+/Ly6G+) myeloid cells from a minimum volume of mouse peripheral blood
Gabriel Cabrera
5. CD4+ T cells proliferation assays to analyze Mo-MDSC suppressive function
Marcos López-Hoyos
6. Assessment of myeloid-derived suppressor cell differentiation ex vivo
Ester Blanco
7. Single clonal tracking on biomimetic microtextured platforms for real-time guided migration analysis of myeloid-derived suppressor cell dissemination characteristics ex vivo
Daniel Gallego-Pérez
8. Isolation and immunosuppressive functions of myeloid-derived suppressor cell-derived exosomes
Ali Syed Arbab
9. Characterization of lysosomal acid lipase in Ly6G+ and CD11c+ myeloid-derived suppressor cells
Ting Zhao and Hong Du
10. In Vitro Osteoclastogenesis Assessment using Murine Myeloid-derived Suppressor Cells
KYU HWAN KWACK and Keith Lough Kirkwood
11. Estimating Nitric Oxide (NO) from MDSCs by Griess Method
Saikat Mukherjee
12. In vitro generation of myeloid-derived suppressor cells (MDSCs) from hematopoietic progenitor cells (HPCs)
Kevin Alicea-Torres

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From the Publisher

Covers myeloid-derived suppressor cells and their critical roles