Nanotechnology for Cancer Therapy / Edition 1

by Mansoor M. Amiji

Overview

While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance for Nanotechnology in Cancer in 2004 and pledged $144.3 million in funding over the next five years.

Edited by one of the most dynamic pioneers in the field, Nanotechnology for Cancer Therapy focuses on those nanoscientific and nanotechnological strategies that are evolving as the most promising for the imaging and treatment of cancer. Among the various approaches considered, nanotechnology offers great possibilities for the targeted delivery of drugs and genes to tumor sites and the ultimate replacement of those chemotherapeutic agents so compromised by side effects.

Within this volume, the expertise of world-renowned academic and industrial researchers is brought together to provide a comprehensive treatise. Composed of 38 chapters, the book is divided into 7 sections that cover -

Fundamentals of targeting strategies, nanotechnology characterization for cancer therapy, and USFDA guidelines on approval of nanotechnology products

Polymeric conjugates used for tumor-targeted imaging and delivery, including imaging to evaluate therapeutic efficacy

Polymeric nanoparticle systems that emphasize biodegradable, long-circulating nanoparticles for passive and active targeting

Polymeric micellar assemblies, where sophisticated chemistry is leading to novel nanosystems that can provide efficient delivery to tumors

Dendritic nanostructures used for cancer imaging and therapy

Liposome-based delivery systems — the oldest nanotechnology method employed in cancer therapy

Other lipid nanosystems used for targeted delivery, including those that can cross biological barriers, as well as mitochondria-specific delivery

Product Details

ISBN-13:	9780849371943
Publisher:	Taylor & Francis
Publication date:	12/19/2006
Pages:	850
Product dimensions:	7.00(w) x 10.00(h) x (d)

About the Author

Dr. Mansoor M. Amiji received his undergraduate degree in pharmacy from Northeastern University in 1988 and his PhD in pharmaceutics from Purdue University in 1992. His areas of specialization include polymeric biomaterials, advanced drug delivery systems, and nanomedical technologies. Dr. Amiji’s research interests include the synthesis of novel polymeric materials for medical and pharmaceutical applications; surface modification of cationic polymers by the complexationinterpenetration method to develop biocompatible materials; the preparation and characterization of polymeric membranes and microcapsules with controlled permeability properties for medical and pharmaceutical applications; target-specific drug and vaccine delivery systems for gastrointestinal tract infections; localized delivery of cytotoxic and anti-angiogenic drugs for solid tumors in novel biodegradable polymeric nanoparticles; intracellular delivery systems for drugs and genes using target-specific, long-circulating, biodegradable polymeric nanoparticles; and gold and iron-gold core-shell nanoparticles for biosensing, imaging, and delivery applications. His research has received sustained funding from the National Institutes of Health (NIH), the National Science Foundation (NSF), foundations, and local industries. Dr. Amiji is Professor and Associate Chair of the Pharmaceutical Sciences Department and Co- Director of the Northeastern University Nanomedicine Education and Research Consortium (NERC). The NERC oversees a doctoral training grant in nanomedicine science and technology that was co-funded by the NIH and NSF. He has two published books, Applied Physical Pharmacy and Polymeric Gene Delivery: Principles and Applications, along with numerous manuscript publications. He has also received a number of awards, including the 2003 Eurand Award for Innovative Oral Drug Delivery Research, Third Prize. Dr. Amiji has supervised the research efforts of over 50 postdoctoral associates, doctoral and mas

Table of Contents

SECTION 1 NANOTECHNOLOGY AND CANCER
Introduction and Rationale for Nanotechnology in Cancer Therapy; Fredika M. Robertson and Mauro Ferrari
Passive Targeting of Solid Tumors: Pathophysiological Principles and Physicochemical Aspects of Delivery Systems; S. M. Moghimi
Active Targeting Strategies in Cancer with a Focus on Potential Nanotechnology Applications; Randall J. Mrsny
Pharmacokinetics of Nanocarrier-Mediated Drug and Gene Delivery; Yuriko Higuchi, Shigeru Kawakami, and Mitsuru Hashida
Multifunctional Nanoparticles for Cancer Therapy; Todd J. Harris, Geoffrey von Maltzahn, and Sangeeta N. Bhatia
Neutron Capture Therapy of Cancer: Nanoparticles and High Molecular Weight Boron Delivery Agents; Gong Wu, Rolf F. Barth, Weilian Yang, Robert J. Lee, Werner Tjarks, Marina V. Backer, and Joseph M. Backer
Preclinical Characterization of Engineered Nanoparticles Intended for Cancer Therapeutics; Anil K. Patri, Marina A. Dobrovolskaia, Stephan T. Stern, and Scott E. McNeil
Nanotechnology: Regulatory Perspective for Drug Development in Cancer Therapeutics; N. Sadrieh and T. J. Miller
SECTION 2 POLYMER CONJUGATES
Polymeric Conjugates for Angiogenesis Targeted Tumor Imaging and Therapy; Amitava Mitra, Anjan Nan, Bruce R. Line, and Hamidreza Ghandehari
Poly (L-Glutamic Acid): Efficient Carrier of Cancer Therapeutics and Diagnostics; Guodong Zhang, Edward F. Jackson, Sidney Wallace, and Chun Li
Noninvasive Visualization of In Vivo Drug Delivery of Paramagnetic Polymer Conjugates with MRI; Zheng-Rong Lu, Yanli Wang, Furong Ye, Anagha Vaidya, and Eun-Kee Jeong
SECTION 3 POLYMERIC NANOPARTICLES
Polymeric Nanoparticles for Tumor-Targeted Drug Delivery; Tania Betancourt, Amber Doiron, and Lisa Brannon-Peppas
Long-Circulating Polymeric Nanoparticles for Drug and Gene Delivery to Tumors; Sushma Kommareddy, Dinesh B. Shenoy, and Mansoor M. Amiji
Biodegradable PLGA/PLA Nanoparticles for Anticancer Therapy; Sanjeeb K. Sahoo and Vinod Labhasetwar
Poly (alkyl cyanoacrylate) Nanoparticles for Delivery of Anticancer Drugs; R. S. R. Murthy and L. Harivardhan Reddy
Aptamers and Cancer Nanotechnology; Omid C. Farokhzad, Sangyong Jon, and Robert Langer
SECTION 4 POLYMERIC MICELLES
Polymeric Micelles for Formulation of Anticancer Drugs; Helen Lee, Patrick Lim Soo, Jubo Liu, Maok Butler, and Christine Allen
PEO-Modified Poly (L-Amino Acid) Micelles for Drug Delivery; Afsaneh Lavasanifar, Xiuo-Bing Xiong, and Hamidreza Montazeri Aliabadi
Hydrotropic Polymer Micelles for Cancer Therapeutics; Sang Cheon Lee, Kang Moo Huh, Tooru Ooy, and Kinam Park
Tumor-Targeted Delivery of Sparingly-Soluble Anti-Cancer Drugs with Polymeric Lipid-Core Immunomicelles; Vladimir P. Torchilin
Combined Cancer Therapy by Micellar-Encapsulated Drug and Ultrasound; Natalya Rapoport
Polymeric Micelles Targeting Tumor pH3; Eun Seong Lee and You Han Bae
cRGD-Encoded, MRI-Visible Polymeric Micelles for Tumor-Targeted Drug Delivery; Jinming Gao, Norased Nasongkla, and Chalermchai Khemtong
Targeted Antisense Oligonucleotide Micellar Delivery Systems; Ji Hoon Jeong, Sun Hwa Kim, and Tae Gwan Park
SECTION 5 DENDRITIC NANOCARRIERS
Dendrimers as Drug and Gene Delivery Systems; Tae-Il Kim and Jong-Sang Park
Dendritic Nanostructures for Cancer Therapy; Ashootosh V. Ambade, Elamprakash N. Savariar, and S. Thai Thayumanavan
PEGylated Dendritic Nanoparticulate Carriers of Anti-Cancer Drug; D. Bhadra, S. Bhadra, and N. K. Jain
Dendrimer Nanocomposites for Cancer Therapy; Lajos P. Balogh and Mohamed K. Khan
SECTION 6 LIPOSOMES
Applications of Liposomal Drug Delivery Systems to Cancer Therapy; Alberto A. Gabizon
Positively-Charged Liposomes for Targeting Tumor Vasculature; Robert B. Campbell
Cell Penetrating Peptide (CPP)-Modified Liposomal Nanocarriers for Intracellular Drug and Gene Delivery; Vladimir P. Torchilin
RGD-Modified Liposomes for Tumor Targeting; S. P. Vyas
Folate Receptor-Targeted Liposomes for Cancer Therapy; Xiaobin B. Zhao, Natarajan Muthusamy, John C. Byrd, and Robert J. Lee
Nanoscale Drug Delivery Vehicles for Solid Tumors: A New Paradigm for Localized Drug Delivery Using Temperature Sensitive Liposomes; David Needham and Ana Ponce
SECTION 7 OTHER LIPID NANOSTRUCTURES
Nanoemulsions Formulations for Tumor-Targeted Delivery; Sandip B. Tiwari and Mansoor M. Amiji
Solid Lipid Nanoparticles for Antitumor Drug Delivery; Ho Lun Wong, Yongqiang Li, Reina Bendayan, Mike Andrew Rauth, and Xiao Yu Wu
Lipoprotein Nanoparticles as Delivery Vehicles for Anti-Cancer Agents; Andras G. Lacko, Maya Nair, and Watter J. McConathy
DQAsomes as Mitochondria-Targeted Nano-Carriers for Anticancer Drugs; Shing-Ming Cheng, Sarathi V. Boddapati, Gerard G. M. D'Souza, and Volkmar Weissig