Neuroimaging Genetics: Principles and Practices

by Kristin L. Bigos, Ahmad R. Hariri, Daniel R. Weinberger

Overview

The field of neuroimaging genetics has grown exponentially over the past decade. To date there are more than 10,000 published papers involving MRI, PET, MEG and genetics.

Neuroimaging Genetics: Principles and Practices is the comprehensive volume edited by Drs. Bigos, Hariri, and Weinberger and co-authored by the preeminent scholars in the field. This text reviews the basic principles of neuroimaging techniques and their application to neuroimaging genetics.

The work presented in this volume elaborates on the explosive interest from diverse research areas in psychiatry and neurology in the use of imaging genetics as a unique tool to establish and identify mechanisms of risk, establish biological significance, and extend statistical evidence of genetic associations. Examples throughout highlight the application of imaging genetics to understand neurochemical systems and pathways, explore relationships between genetics and the structural and functional connectivity in human brain, and provide insight into mechanisms of risk for psychiatric and neurologic illness.

Product Details

ISBN-13:	9780199920211
Publisher:	Oxford University Press
Publication date:	03/02/2016
Pages:	432
Product dimensions:	8.60(w) x 11.00(h) x 1.10(d)

About the Author

Kristin L. Bigos is Investigator at the Lieber Institute for Brain Development and Assistant Professor of Medicine in the Division of Clinical Pharmacology at Johns Hopkins School of Medicine.

Ahmad R. Hariri is a Professor in the Department of Psychology and Neuroscience at Duke University.

Daniel R. Weinberger is Director and CEO at the Lieber Institute for Brain Development and Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine.

Table of Contents

1. Neuroimaging genetics
Kristin L. Bigos, Ahmad R. Hariri, Daniel R. Weinberger

Imaging Genetics and Neurochemistry

2.Molecular Neuroimaging Genetics
Patrick M. Fisher, Gitte Moos Knudsen

3. Neuroreceptor Imaging of Genetic Variation Impacting the Serotonin Transporter
Greg Perlman, Christine DeLorenzo, J. John Mann, Ramin Parsey

4. Imaging of Genetic Variation Impacting Dopamine Transmission Parameters
Elsmarieke van de Giessen, Rassil Ghazzaoui, Raj Narendran, Anissa Abi-Dargham

5. Imaging Genetics of Dopamine Synaptic Terminal Activity
Giuseppe Blasi, Alessandro Bertolino

Imaging Genetics and Drug Discovery

6. Variability of Antidepressant Drug Response: Contribution of Imaging Genetics studies
Ulrich Rabl, Bernhard M. Meyer, Lukas Pezawas

7. Imaging Genetics of Pharmacological Response in Psychiatric Disorders
Philip R. Szeszko, Anil K. Malhotra

Imaging Genetics and Genetic Discovery

8. Imaging Genetics of Williams Syndrome
Daniel P. Eisenberg, Ranjani Prabhakaran, Karen F. Berman

9. Identifying Unanticipated Genes and Mechanisms in Serious Mental Illness: GWAS Based Imaging Genetics Strategies
Steven G. Potkin, Theo G. M. van Erp, Shichun Ling, Fabio Macciardi, Xiaohui Xie

10. Imaging Genetics of Brain Structure
Jason L. Stein, Derrek P. Hibar, Paul M. Thompson

11. Imaging Genetics of the Reward System
Caroline F. Zink

Imaging Genetics and Disease

12. Imaging Genetics of Schizophrenia
Thomas M. Lancaster, Joanne L. Doherty, David E. Linden, Jeremy Hall

13. Imaging Genetics of Depression
Matthew D. Sacchet, Lara C. Foland-Ross, Ian H. Gotlib

14. Imaging Genetics of Anxiety Disorders
Mats Fredrikson

15. Imaging Genetics of Bipolar Disorder
Martin Tesli, Ole A. Andreassen

16. Genetic-neuroimaging Studies of Basal Ganglia Disorders
Trevor W. Robbins, James B. Rowe, Roger A. Barker

17. Imaging Genetics of Antisocial Behavior and Psychopathy
Hayley M. Dorfman, Joshua W. Buckholtz

Imaging Genetics and the Environment

18. Incorporating the Environment into Neurogenetics Research: An Imaging Gene by Environment Interactions (IG x E) Approach
Luke W. Hyde, Ryan Bogdan, Ahmad R. Hariri

Imaging Genetics and Cognition

19. Imaging Genetics of Episodic Memory
Björn Rasch, Susanne Erk, Andreas Papassotiropoulos, Dominique J.-F. de Quervain

20. Imaging Genetics of Working Memory
Tristram A. Lett, Eva J. Brandl, Daniel J. Müller, Andreas Heinz, Henrik Walter

Imaging Genetics of Advancing Age

21. Neurobiology and Genetics of Cognitive Aging: Insights from Neuroimaging Studies
John C. Muse, Milap A. Nowrangi, Daniel R. Weinberger, Venkata S. Mattay

22. Neuroimaging Genetics of Alzheimer's Disease
Theresa M. Harrison, Alison C. Burggren, Susan Y. Bookheimer

Imaging Genetics and Multi-Locus Models

23. Imaging Genetics of the Hypothalamic Pituitary Adrenal Axis: Implications for Psychopathology
Nadia S. Corral-Frias, Lindsay J. Michalski, Christina R. Di Iorio, Ryan Bogdan

Index

Editorial Reviews

Reviewer: Michael Schrift, DO (University of Washington School of Medicine)
Description: A major impediment for the advancement of scientific knowledge in psychiatry has been the inability to use clinical pathological correlations, as the rest of medicine has had, over the past 150 years. In order for us to have a valid nosology and eventually effective and scientifically rational treatments, we need to understand specific brain-behavior relationships. In addition, phenotypes (such as behavior and cognition) in psychiatry have been, heretofore, too complex to study. The development, over the past several decades, of both functional and structural neuroimaging tools, has enabled a much greater understanding of these complex brain-behavior relationships. It has also allowed us to begin to understand genotype-phenotype (specifically endophenotype correlations), that is, how gene activity affects neural network activation when performing specific cognitive (or emotional) tasks. This book, which covers the current state of the science of the principles and practices of neuroimaging genetics, is a testament to how far this field has advanced.
Purpose: The aim, according to its editors, is to survey "the field from its history to its future, providing unique insight into how genes influence brain structure and function." They note, "This book highlights the best of imaging genetics research and the future of this field, which has great potential for elucidating human neuroscience and for the biologic validation of genetic mechanisms and neuropsychiatric disorders." Indeed, the editors and chapter authors have produced a magnificent book for this burgeoning field.
Audience: The targeted audience includes researchers in psychiatry, the neurosciences, and genetics. Clinicians who want to keep abreast of this very important field should read this book as well. Written and edited by outstanding array of internationally recognized scientists in the field, it is a very welcome addition to the scientific literature.
Features: The introductory chapter is an excellent overall view of the field. Part one covers imaging genetics and neurochemistry with chapters on molecular neuroimaging genetics, neural receptor imaging of the serotonin transporter, the imaging of genetic variation impacting domain transmission, and imaging genetics of dopamine synaptic terminal activity. Part two focuses on drug discovery, with chapters covering imaging genetic studies of antidepressant drug response, and imaging genetics of pharmacological response and psychiatric disorders. Part three covers an interesting area of imaging genetics and genetic discovery, with fascinating information on the imaging genetics of William syndrome, identifying unanticipated genes and mechanisms in serious mental illness, the genetics of brain structure, and the genetics of reward processing in the human brain. The fourth part of the book covers the imaging genetics of specific neuropsychiatric diseases including schizophrenia, depression, anxiety disorders, bipolar disorder, basal ganglia disorders, antisocial behavior, and psychopathy. Part five covers an important area of imaging of gene-environment interactions. Cognition and imaging genetics is covered in part six with chapters focusing on the imaging genetics of episodic memory and working memory. The imaging genetics of cognitive aging is covered in part seven with chapters on the neuroimaging genetics of cognitive aging and of Alzheimer's disease. The final part covers imaging genetics and multi-locus models with a chapter on the imaging genetics of hypothalamic-pituitary-adrenal axis with implications for psychopathology. This is a very scholarly book with relevant and timely citations of the scientific literature at the end of each chapter.
Assessment: This is a superb and fascinating book covering an extremely important area of research in neuroscience, neuroimaging genetics. Anyone interested in learning about this dazzling area of neuroscience research should read this book.

Doody's Review Service

"Neuroimaging Genetics: Principles and Practice edited by Bigos, Hariri and Weinberger is the first volume in the field devoted to this burgeoning area of research. It brings together many of the pioneering investigators in the field who collectively summarize the history and current state of the art... [and] includes both chapters on specific neurochemically defined circuits including serotonin and dopamine, as well as those that are more disease specific, e.g schizophrenia, Williams syndrome, anxiety disorders and bipolar disorder. ... For the interdisciplinary investigator/student at the interface of genetics, neuroradiology, psychiatry, and neurology, this will be an enjoyable, informative read." —Charles B. Nemeroff, MD, PhD, Leonard M. Miller Professor and Chairman, Department of Psychiatry and Behavioral Sciences, Director, Center on Aging, Leonard M. Miller School of Medicine, University of Miami, FL

"In the few years since this method was initially conceived, imaging genetics has emerged as a valuable tool to understand mechanisms of psychiatric disease, understanding how genes work on the level of brain, and to guide the search for new treatments. ... Scholarly and practical at the same time, this book will be an asset to the library of researchers in psychiatry, neuroscience, and genetics, as well as for practitioners curious where the research frontier now lies." —Andreas Meyer-Lindenberg, MD, Director and CEO, Central Institute of Mental Health, Mannheim; and Chair of Psychiatry and Psychotherapy, University of Heidelberg / Medical Faculty Mannheim, Germany

From the Publisher