Neuroinflammation: Mechanisms and Management

by Paul L. Wood (Editor)

Overview

In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.

Product Details

ISBN-13:	9781592592975
Publisher:	Springer-Verlag New York, LLC
Publication date:	12/18/2002
Series:	Contemporary Neuroscience
Sold by:	Barnes & Noble
Format:	eBook
Pages:	436
File size:	9 MB

About the Author

Wood, Paul L. (CoCensys, Irvine, CA)

The contributors represent the specialties of pharmacology, pharmaceutics, neurology, and neuroscience. Most are from private pharmacuetical companies and academic medical centers in the U.S., including Parke Davis Pharmaceuticals, Amgen, and Kentucky Medical Center.

Table of Contents

I. Neuroinflammatory Mechanisms.- 1 Microglia: Roles of Microglia in Chronic Neurodegenerative Diseases.- 2 Apoptosis vs Nonapoptotic Mechanisms in Neurodegeneration.- 3 Role(s) of Mitogen and Stress-Activated Kinases in Neurodegeneration.- 4 Roles of Chemokines and Their Receptors in Neuroinflammation.- 5 Neurotoxic Mechanisms of Nitric Oxide.- 6 Chronic Intracerebral LPS as a Model of Neuroinflammation.- 7 Peroxisome Proliferator-Activated Receptor Gamma Agonists: Potential Therapeutic Agents for Neuroinflammation.- 8 Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases: Potential of Nitronesas Therapeutics.- II. Stroke and TBI.- 9 Inflammation and Potential Anti-Inflammatory Approaches in Stroke.- 10 Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injury.- 11 Type IV Collagenases and Blood-Brain Barrier Breakdown in Brain Ischemia.- III Alzheimer’s Disease.- 12 Neuroinflammatory Environments Promote Amyloid-? Deposition and Posttranslational Modification.- 13 Microglial Responses in Alzheimer’s Disease: Recent Studies in Transgenic Mice and Alzheimer’s Disease Brains.- 14 The Amyloid Hypothesis of Cognitive Dysfunction.- 15 The Cerebellum in AD: A Case for Arrested Neuroinflammation?.- 16 The Neuroinflammatory Components of the Trimethyltin (TMT) Model of Hippocampal Neurodegeneration.- 17 Inflammation and Cyclo-Oxygenase in Alzheimer’s Disease: Experimental Approaches and Therapeutic Implications.- IV. Multiple Sclerosis.- 18 Experimental Autoimmune Encephalomyelitis.- 19 Neuroimmunologic Mechanisms in the Etiology of Multiple Sclerosis.- 20 In Vivo Imaging of Neuroinflammation in Neurodegenerative Diseases.- V. Parkinson’s and Huntington’s Diseases.- 21 Inflammatory Mechanisms in Parkinson’s Disease.- 22 Neuroinflammatory Components of the 3-Nitropropionic Acid Model of Striatal Neurodegeneration.

Editorial Reviews

Reviews the current understanding of the neuroinflammatory mediators and cells involved in neurodegenerative diseases. Begins with current views of how they are implicated in neuronal loss and the mechanisms of cell death, then critically examines current research on designing specific pharmacological agents to inhibit the neuroinflammatory cascade at defined points. Also addresses the molecular, cellular, and disease-model actions of first-generation agents and the potential clinical relevance to AIDS-related dementia, Alzheimer's disease, amyotrophic lateral sclerosis, Down's syndrome, Huntington's and Parkinson's diseases, multiple sclerosis, and stroke. Of interest to researchers and clinicians in the field. Annotation c. by Book News, Inc., Portland, Or.

Booknews

Review of the first edition:

"...will reach a wide audience including basic and clinical neuroscientists. . .fills a significant gap in the literature...provides an excellent starting point, and offers insight into the rapid pace of discovery within a field which influences most aspects of nervous system function."-Nature Medicine

"...fills a significant gap in the literature...provides an excellent starting point..."

-Nature Medicine

"...will be useful to a wide variety of researchers and clinicians, particularly [those] interested in neurodegenerative disorders ..."

-Neurological Research

"...provides a thorough overview of cells and mechanisms of brain inflammation, their role in disease and future therapeutic avenues to overcome it."

-Microbiology Today

"...a timely addition that will aid our understanding today."

-Receptors & Signal Transduction

From the Publisher