Neuromodulation: The Biochemical Control of Neuronal Excitability

by Leonard K. Kaczmarek, Irwin B. Levitan

Overview

This volume provides an introduction to the general principles of neuromodulation—the key neurobiological process for understanding how the brain works. Emphasizing ion channels and biochemical mechanisms of protein phosphorylation, the book shows how neurons regulate their intracellular calcium concentration by modulating the activity of certain ion channels. It goes on to explain the function of intracellular calcium and describes some fascinating neuromodulatory phenomena in the mammalian brain that have long awaited the kind of mechanistic investigations possible in simpler systems. Bridging the gap between neurochemistry and neurophysiology, the authors make complex concepts and research approaches comprehensible to scientists in either field.

Product Details

ISBN-13:	9780195040975
Publisher:	Oxford University Press
Publication date:	11/06/1986
Pages:	304
Product dimensions:	9.21(w) x 6.14(h) x 0.69(d)

About the Author

Yale University

Brandeis University

Table of Contents

1. What is Neuromodulation?, Leonard K. Kaczmarek and Irwin B. Levitan2. Ion Currents and Ion Channels, Substrates for Neuromodulation, Irwing B. Levitan and Leonard K. Kaczmarek3. Mechanisms and Modulation of Ion Channel Proteins, Christopher Miller4. Biochemical Mechanisms in the Modulation of Ion Channel Function, Richard L. Huganir5. Phosphorylation of Purified Ion Channel Proteins, Richard L. Huganir6. Modulation of the Endogenous Rhythmic Bursting Activity in the Aplysia Neuron R15, Jack A. Benson and William B. Adams7. Modulation of Voltage-Dependent Potassium Currents During Long-Lasting Changes in Neuronal Activity, Judith A. Strong and Leonard K. Kaczmarek8. Modulation of Ion Channels Which are Regulated by Calcium, Douglas A. Ewald and Leonard K. Kaczmarek9. Modulation of Potassium Currents of Vertebrate Neurons, Stephen W. Jones and Paul R. Adams10. Modulation of a Potassium Channel in Aplysia Ssensory Neurons by Cyclic AMP-dependent Protein Phosphorylation, Stephen A. Siegelbaum11. Modulation of Calcium Currents in Heart Cells and Neurons, Richard W. Tsien12. Neurotransmitter Release and Its Modulation, Robert S. Zucker13. Neuromodulation in the Mammalian Brain: The New Frontier, Val Gribkoff and F. Edward Dudek