Neurosteroid Effects in the Central Nervous System: The Role of the GABA-A Receptor

by Sheryl S. Smith (Editor)

Overview

Our understanding of the ways that neuroactive steroids act in the brain has been increased by transgenic approaches, recombinant expression systems, higher resolution electrophysiological paradigms, and the development of technology to localize receptors. Recent behavioral studies examining the effects of steroids on mood, seizure susceptibility,

Product Details

ISBN-13:	9780203508169
Publisher:	CRC Press
Publication date:	10/27/2003
Series:	Frontiers in Neuroscience
Sold by:	Barnes & Noble
Format:	eBook
Pages:	408
File size:	5 MB

About the Author

Sheryl S. Smith

Table of Contents

Contents Introduction
Synthesis, enzyme localization, and regulation of neurosteroids,
Synthia H. Mellon
Subunit specificity of steroid modulation of GABA_A receptors, R.W. Olsen, E. Cagetti and M. Wallner
THDOC and the GABA-A receptor, S. Vicini
Neurosteoid modulation of delta subunit-containing GABA_A receptor channels, M.T. Bianchi and R.L. Macdonald
Potentiation and inhibition of GABA_A receptor function by neuroactive steroids, L.N. Eisenman, Y. He, D.F. Covey, C.F. Zorumski, S. Zorumski, and S. Mennerick
Anabolic androgenic steroids and the brain: Novel actions at the GABA_A receptor and on GABA_A receptor mediated behaviors, A.S. Clark, B.L. Jones, P. Yang, and L. Henderson
Withdrawal effects of a neuroactive steroid as a model of PMS: Synaptic physiology to behavior, S. Smith
GABA, estrogen, and sex differences in the brain, M.M. McCarthy, J.L. Nunez, and T.S. Perrot-Sinal
FGIN-1-X--A series of novel specific and efficacious ligands for the peripheral benzodiazepine receptor, E,M. Skowronski-Lutz and D, Bitran
GABAergic neuroactive steroids modulate selective ethanol actions: mechanisms and significance, A.L, Morrow, R, Khisti, S, Tokunaga, J,R. McDaniel, and D.B. Matthews
Allopregnanolone modulates the action of ethanol and stress on the activity of mesocortical dopaminergic neurons and HPA axis, G. Biggio, L. Dazzi, and M. Serra
3a, 5a-THP's actions in the ventral tegmental area for lordosis: A model system for defining mechanisms and function of progestins, C.A. Frye and S.M. Petralia
Premenstrual dysphoric disorder, I. Sundstrom-Poromaa
Role of neurosteroids in epilepsy, Z. Mtchedlishvili and J. Kapur
Animal models of anxiety and stress-induced behavior: Effects of neuroactive steroids, D.A. Finn, R.H. Purdy and G.F. Koob
Direct modulation of amino acid receptors by neuroactive steroids: Physiological and pharmacological Implications, T.T. Gibbs and D. Farb
On the neurosteroid mechanisms of action and their clinical potentials, Y. Akwa and E. Baulieu

Editorial Reviews

The overwhelming amount of information in the field is well presented in the superbly written book, the magnificent pictures, and the up-to-date references. This is a good purchase for general neurological and neuroscience libraries.”
— Doody’s
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From the Publisher

Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: Neurosteroids have been recognized as neuroprotectants for many decades. The mechanism of action, however, has been elucidated just recently. New discoveries have been discussed constantly in the literature.
Purpose: The purpose of this book is to address the effects of neurosteroids in the nervous system. The authors fully meet their objectives in an easy and straightforward approach.
Audience: Neurologists, neurosurgeons, and neuroscientists are the intended audience for this book. Steroids are used in everyday clinical practice and an approach to the known mechanisms of action is helpful in determining the course of future therapies for the nervous system.
Features: Forty-one contributors author the 17 chapters in this book. The main aspects discussed are the role of GABA receptors in the modulation of effects in the central nervous system. The overwhelming amount of information in the field is well presented in the superbly written book, the magnificent pictures, and the up-to-date references.
Assessment: This is a good purchase for general neurological and neuroscience libraries.

Doody's Review Service