Opiate Receptors and Antagonists: From Bench to Clinic / Edition 1

by Reginald Dean, Edward J. Bilsky, S. Stevens Negus

Overview

The evolution in our understanding of opioid receptors and their subtypes is in- mately linked to the development of new pharmacological treatments for diseases/ disorders as diverse as addiction, self-injurious behavior, pain, cancer, infl- mation, eating disorders, traumatic injury, pruritis, and movement disorders. These potential treatments involve both novel chemical entities and classic opioid antagonists with improved drug delivery systems. The contributions contained in Opioid Receptors and Antagonists: From Bench to Clinic represent the efforts from some of the leading international scientists and clinicians making use of the l- est information emerging from the study of the opioid receptor system. Given the number of researchers currently active in this and related fields of study, it would be inappropriate to suggest that the entire range of activities is fully reflected in this single volume. Instead, a variety of experimental and clinical approaches involving the fields of neuroscience, molecular biology, biochemistry, anatomy, pharmacology, psychology, and psychiatry have been chosen to illustrate rapidly developing experimental and therapeutic areas.

Product Details

ISBN-13:	9781588298812
Publisher:	Springer-Verlag New York, LLC
Publication date:	03/09/2009
Series:	Contemporary Neuroscience
Edition description:	2009
Pages:	757
Product dimensions:	6.10(w) x 9.25(h) x 0.06(d)

Table of Contents

Opioid Receptors.- Ultra-Low-Dose Opioid Antagonists Enhance Opioid Analgesia and Reduce Tolerance.- Upregulation of Opioid Receptors.- Imaging Human Brain Opioid Receptors: Applications to Substance Use Disorders.- Opioid Receptor Antagonist-Mediated Signaling in the Immune System.- Opioid Antagonists: Chemistry and Pharmacology.- The Chemistry and Pharmacology of—-Opioid Antagonists.- Medicinal Chemistry of Kappa Opioid Receptor Antagonists.- The Chemistry and Pharmacology of Delta Opioid Antagonists.- Novel Opioid Antagonists with Mixed/Dual Selectivity.- Experimental Utility and Clinical Potential of Irreversible Opioid Antagonists.- Methylnaltrexone: A Peripherally Acting Opioid Antagonist.- Substance Abuse.- Opioid Antagonist Effects in Animal Models Related to Opioid Abuse: Drug Discrimination and Drug Self-Administration.- Naltrexone for Initiation and Maintenance of Opiate Abstinence.- Ultra-Low-Dose Naltrexone Decreases Dependence and Addictive Properties of Opioids.- Can a Combination Formulation Containing a Neutral Opiate Antagonist Decrease the Abuse of—-Agonist Opiates.- Effects of Opioid Antagonists on the Abuse-Related Effects of Psychomotor Stimulants and Nicotine.- Potential Use of Opioid Antagonists in the Treatment of Marijuana Abuse and Dependence.- Naltrexone in Smoking Cessation: A Review of the Literature and Future Directions.- Alcohol and Ingestive Behaviors.- Opioid Antagonists and Ethanol's Ability to Reinforce Intake of Alcoholic Beverages: Preclinical Studies.- Clinical Use of Opioid Antagonists in the Treatment of Alcohol Dependence.- Preclinical Effects of Opioid Antagonists on Feeding and Appetite.- CNS Opiate Systems and Eating Disorders.- Behavioral Disorders.- Potential Utility of Kappa Ligands in the Treatment of MoodDisorders.- Opioid Antagonists in the Treatment of Pathological Gambling and Kleptomania.- Efficacy of Opioid Antagonists in Attentuating Self-Injurious Behavior.- Pharmacotherapeutic Effects of Opioid Antagonists in Alcohol-Abusing Patients with Schizophrenia.- Medical Indications.- Current Issues in the Use of Opioid Antagonists (Naltrexone for Opiate Abuse: A Re-Educational Tool as Well as an Effective Drug).- Emergency Room Use of Opioid Antagonists in Drug Intoxication and Overdose.- Kappa-Opioid Antagonists as Pruritogenic Agents.- Clinical Effect of Opioid Antagonists on Clinical Pruritus.- Effects of Opioid Antagonists on l-DOPA-Induced Dyskinesia in Parkinson's Disease.- Endocrine Effects of Opioid Antagonists.- Opioid Antagonists in Traumatic Shock: Animal and Human Studies.- The Efficacy of Opioid Antagonists Against Heatstroke-Induced Ischemia and Injury in Rats.- A Review of the Opioid System in Cancer Patients and Preliminary Results of Opioid Antagonists in the Treatment of Human Neoplasms.- Nonclinical Pharmacology of VIVITROL®: A Monthly Injectable Naltrexone for the Treatment of Alcohol Dependence.- The Development of Sustained-Release Naltrexone and Clinical Use in Treating Opiate Dependence.- The Development of ProNeura Technology for the Treatment of Addictions.- Development of Opioid Transdermal Delivery Systems.- Intranasal Naloxone for Treatment of Opioid Overdose.

Editorial Reviews

Reviewer: Michael Easton, MD (Rush University Medical Center)
Description: This is an extensive review of the scientific research on opioid receptors and opioid receptor antagonists from theory to their applications and uses in various clinical conditions.
Purpose: This exceptional reference provides up-to-date reviews of the scientific literature and emerging data on the opioid-receptor system. It covers the basic science, including the molecular biology, biochemistry, anatomy, and pharmacology, and goes on to the clinical areas of behavioral neurosciences and psychiatric illnesses and how manipulation of this system affects various disorders.
Audience: This book is meant as a reference for both scientists and clinicians involved in the research or clinical application of opiate receptor antagonists.
Features: The history behind the development of the opioid antagonist naltrexone begins the book, which then goes on to review the characteristics of opioid receptors and describe the chemistry and pharmacology of opioid antagonists. It reviews the wide variety of clinical areas where these agents can be used: substance abuse (opiates, alcohol, nicotine and cannabis); behavioral disorders (appetite, eating disorders, mood disorders, pathological gambling, kleptomania, and self-injurious behavior); and other medical uses. The book finishes with a look at the development of innovative drug-delivery approaches being used with opioid antagonists.
Assessment: This is a comprehensive, detailed, and thorough reference on opiate receptors, opiate receptor antagonists, and the scientific data regarding their current use as well as potential clinical applications. The book also suggests future areas of research for the treatment of brain reward disorders as well as other medical indications where opioid receptor antagonists may be effective.

Doody's Review Service

From the reviews:

“The authors do an excellent job of providing insight into the background of the many factors related to opioid receptor antagonists. … Overall, this work is a well written and interesting text and would be a very useful addition to the personal libraries of those medicinal chemists with a research interest in the modulation of the opioid receptor system.” (Thomas E. Prisinzano, Journal of Medicinal Chemistry, Vol. 53 (2), March, 2010)

“This book is focused on the therapeutic uses of opioid antagonists ranging from classical opioid antagonists to novel chemical entities. In any therapeutic field examined, the aim of book as outlined by the title–‘From Bench to Clinic’–is achieved. … The clinical applications of opioid antagonists are extensively discussed in almost all chapters of this book … . In conclusion, this book gives an interesting analysis of the different fields of knowledge and research concerning therapeutic uses of opioid antagonists in recent years.” (Agostino Marrazzo, ChemBioChem, Vol. 5, 2010)

From the Publisher