Osteoimmunology: Interactions of the Immune and Skeletal Systems

by Joseph Lorenzo (Editor), Mark Horowitz (Editor), Yongwon Choi (Editor), Hiroshi Takayanagi (Editor), Georg Schett (Editor)

Overview

Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology.

This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics.

Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget’s disease, the genetics of bone disease, and bone cancer metastasis.

• Explains the intricate interaction between the immune system and bone
• Features detailed discussions of the key cellular and molecular mechanisms governing the homeostasis of the individual systems
• Facilitates greater understanding of osteoimmunologic networks, their environments, and how this understanding leads to better treatments for human diseases involving both systems

Product Details

ISBN-13:	9780128006276
Publisher:	Elsevier Science
Publication date:	09/23/2015
Sold by:	Barnes & Noble
Format:	eBook
Pages:	376
File size:	18 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Lorenzo is Professor of medicine in the Division of Endocrinology and Metabolism and Director of Bone Biology Research at the University of Connecticut Health Center. He is a nationally renowned expert on bone remodeling and its effect on bone health.
Dr. Horowitz is Professor of Orthopaedics and Rehabilitation at the Yale University School of Medicine. His research interests include the interactions between the skeletal, immune, and hematopoietic systems as they relate to normal and pathologic bone remodeling.
Dr. Choi is Professor of Pathology and Laboratory Medicine, University of Pennsylvania; Investigator, The Leonard and Marilyn Abramson Family Cancer Research Institute, Philadelphia, PA.
Dr. Takayanagi is Professor in the Department of Cell Signaling, Tokyo Medical and Dental University. His group studies the mechanism of bone destruction in rheumatoid arthritis, which focuses on the regulation of osteoclasts by T cells. This interdisciplinary field, osteoimmunology, covers various research on shared mechanisms and interactions between immune and bone systems.

Table of Contents

1. Overview

2. Origins of the Osteoclast

3. Trafficking of Osteoclast Precursors

4. Osteoclast Biology: Regulation of Formation and Function

5. Osteoblasts and the Immune system

6. Osteocyte Biology

7. Bone Cells and the Hematopoietic Niche

8. The Function of RANKL Beyond the Osteoclast

9. The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells

10. Coupling Between Immune and Bone Cells

11. The Role of the Immune System in the Development of Osteoporosis and Fracture Risk

12. The Role of Sex Steroiods in the Interactions of the Immune System with Bone

13. The Role of the Immune System in the Local and Systemic Bone Loss of Inflammatory Arthritis

14. Osteoarthritis and the Immune System

15. Inflammatory Bowel Disease and Bone

16. The Role of the Immune System and Bone Cells in Acute and Chronic Osteomyelitis

17. The Role of the Immune System in Fracture Healing

18. The Role of the Immune System in the Effects of Cancer on Bone

19. Osteoimmunology in the Oral Cavity (Periodontal Disease, Lesions of Endodontic Origin and Orthodontic Tooth Movement)

20. The Role of the Immune System in the Interactions of Fat and Bone

What People are Saying About This

From the Publisher

The first book to focus on the interactions of bone and immune cells

Editorial Reviews

"Edited by four pioneers in the field of osteoimmunology, this book contains chapters by 44 outstanding experts, spanning the breadth and depth of our current knowledge of osteoimmunology from cell and molecular biology to clinical problems."
— Tatsuo Suda, Member of the Japan Academy, Associate Member, Science Council of Japan, Emerutus Professor of Showa University, Visiting Professor, Research Center for Genomic Medicine, Saitama Medical University, Japan

"The new textbook of osteoimmunology provides a comprehensive introduction to this recently established field that seeks to bridge two-well established disciplines. By reviewing both well-established concepts in bone biology and recent advances in our understanding of the interactions between the immune and skeletal systems, the text serves as both an excellent introduction to the field and a state of the art summary. Overall, each chapter provides concise history of work in the area, thus both immunologists and bone biologists can gain a view of how current paradigms evolved to their current states. This makes the book of particular use to trainees that have studied primarily immunology or bone biology in the past but know little about the other. Early chapters focus on specific cell types in the bone such as osteoclasts or osteoblasts and review both the cellular differentiation and function and our current knowledge regarding immune regulation of the cells. Later chapters nicely focus on specific pathologic states in the bone such as inflammatory arthritis or fracture healing and provide a comprehensive review of studies investigating the role of the immune system in these models. The field of osteoimmunology is rapidly expanding and evolving quickly, this textbook will help put all of us on the same page and help us understand how we got here."
— Mary C. Nakamura M.D., Associate Professor of Medicine, UCSF, Division of Rheumatology, San Francisco, CA, USA

From the Publisher