Oxford Textbook of Endocrinology and Diabetes

by John Wass (Editor), Wiebke Arlt (Editor), Robert Semple (Editor)

Overview

Now in its third edition, the Oxford Textbook of Endocrinology and Diabetes is an up-to-date, objective and comprehensive text that covers the full scope of endocrinology and diabetes. It contains wide ranging and pragmatic advice on diagnosis and clear guidelines for recommended management, while also covering the scientific principles that underlie the medical practice in this important field. The book has been re-organised into 15 overarching sections, with new sections on Endocrinology of Pregnancy and Management of the Transgender Patient included. All other sections have been extensively updated and restructured. Each chapter is written by an internationally acknowledged expert, relates basic science to evidence based guidelines and clinical management, and where appropriate offers an outline of the controversies in the subject. The textbook has an international focus and deals with subject matter applicable across the globe. The new edition has over 800 images complementing the extensive text and information provided. The book is a 'one-stop' text for trainees and consultants in Endocrinology and Diabetes, residents, those preparing for sub-specialty exams and other professionals allied to the area who need to gain an understanding of the field. It acts as both a point of reference for the experienced consultant as well as a trusted training resource. Purchase of the print work also includes full access to the online edition of the textbook for the life of the edition.

Product Details

ISBN-13:	9780192523280
Publisher:	OUP Oxford
Publication date:	03/10/2022
Sold by:	Barnes & Noble
Format:	eBook
Pages:	2160
File size:	159 MB
Note:	This product may take a few minutes to download.

About the Author

Professor Wass is a Professor of Endocrinology at Oxford University and was the Head of the Department of Endocrinology at the Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital Oxford, UK until 2011. From 1989 he was Professor of Clinical Endocrinology and Sub-Dean, University of London at Bart?s. He founded and ran the Oxfordshire Osteoporosis Service in 1995. John Wass is currently the Clinical Reference Group Chair for Endocrinology in the UK. He was President of the European Federation of Endocrine Societies from 2001-2203 and was Chairman of the Society for Endocrinology (2006-2009). He was awarded the Distinguished Physician of the Year Award by the American Endocrine Society, the first non-American to ever receive this award Elected Academic Vice President of the Royal College of Physicians London in 2012 he has chaired the Royal College of Physicians Working Party 'Action on Obesity: Comprehensive Care for All' published in January 2013. Wiebke Arlt qualified at the University of Cologne in 1990. She trained in Endocrinology from 1994 to 1998 under the auspices of Professor Bruno Allolio at the University Hospital W?rzburg, Germany. She then spent two years in the Molecular Endocrinology Lab of the Department of Paediatrics at the University of California in San Francisco (UCSF), hosted by Walter Miller. Following her return to Wuerzburg in 2001 she was appointed Consultant Endocrinologist. She obtained a prestigious Heisenberg Fellowship from the German Research Council and moved to Birmingham in October 2002. In 2004, she obtained an MRC Senior Clinical Fellowship and was appointed Senior Lecturer at the University of Birmingham. Promotion to Chair of Medicine in 2006 and to Head of the Centre for Endocrinology, Diabetes and Metabolism in 2008. She was awarded the William Withering Chair of Medicine in 2014 and appointed as Director of the newly founded Institute of Metabolism and Systems Research in 2015. Professor Semple is an endocrinologist based at the University of Edinburgh, where he is also Dean of Postgraduate Research for the College of Medicine and Veterinary Medicine. His interests include insulin resistance, diabetes, hypoglycaemia and mosaic growth disorders, in each of which he engages in fundamental molecular and cellular research, translational studies, and clinical practice.

Table of Contents

1. Principles of basic and clinical endocrinology1.1. Endocrine Practice Fundamentals, Lynn Loriaux1.2. Hormones and receptors: fundamental considerations, John W. Funder1.3. Molecular aspects of hormonal regulation, Ken Siddle and Gemma Brierley1.4. Endocrinology and evolution: lessons from comparative endocrinology, Janine A. Danks and Samantha J. Richardson1.5. Hormones Across the Lifespan, James Gibney, Indi Banerjee, and Ken Ho1.6. Pituitary assessment strategy, Brian Keevil, Peter Trainer, and William Drake1.7. Endocrine autoimmunity, Simon Pearce and Catherine Owen1.8. Common Features of Endocrine Tumours, Jerome Bertherat, Anne Jouinot, and Fidéline Bonnet-Serrano1.9. Genetic Aspects of Endocrine Disease, Trevor Cole1.10. Environmental Influences on Endocrine Disease, George Mastorakos, Markella Nezi, Djuro Macut, and Maria Papagianni1.11. Endocrinology, sleep and circadian rhythms, Georg Brabant and H. Oster1.12. Principles of Hormone replacement, Richard Ross1.13. Prevention in endocrinology, Jonathan Valabhji and Rochan Agha-Jaffar2. Pituitary and hypothalamic diseases2.1. Functional anatomy of the hypothalamus and pituitary, John Morris2.2. The neurohypophysis, Stephen G. Ball2.3. Aetiology, pathogenesis, and management of disease of the pituitary2.3.1. Development of the pituitary and genetic forms of hypopituitarism, Mehul T. Dattani and Louise C. Gregory2.3.2. Molecular pathogenesis of pituitary tumours, Shlomo Melmed2.3.3. Histopathology of pituitary tumours, Luis Syro, Kalman Kovacs, and Fabio Rotondo2.3.4. Imaging of the pituitary, Jean-Francois Bonneville, Sonia Nagi, and Iulia Potorac2.3.5. Hypopituitarism: replacement of adrenal, thyroid, and gonadal axes, Miles J. Levy, Ragini Bhake, and Narendra Reddy2.3.6. Adult growth hormone deficiency, Jens Jørgensen2.3.7. Surgery of pituitary tumours, Edward R. Laws Jr, David L. Penn, and Caroline S. Repetti2.3.8. Pituitary radiotherapy, Naomi Fersht and Francesca Solda2.3.9. Prolactinomas and hyperprolactinaemia (including macroprolactinaemia), Nicholas Tritos and Anne Klibanski2.3.10. Acromegaly, John Wass, Peter J. Trainer, and Márta Korbonits2.3.11. Clinically nonfunctioning pituitary tumours and gonadotropinomas, Nienke Biermasz and Wouter R. van Furth2.3.12. Thyrotropinomas, Mark Gurnell, Olympia Koulouri, and Waiel Bashari2.3.13. Pituitary carcinoma, Ann McCormack2.3.14. Pituitary incidentalomas, Niki Karavitaki, Shu Teng Chai, and Shahzada Ahmed2.4. Aetiology, pathogenesis, and management of diseases of the hypothalamus2.4.1. Hypothalamic dysfunction (hypothalamic syndromes), Mehul Dattani, Hoong-Wei Gan, and Manuela Cerbone2.4.2. Craniopharyngiomas, Niki Karavitaki2.4.3. Perisellar tumours including cysts, hamartomas, and vascular tumours, Jürgen Honegger, Ulrike Ernemann, and Rudi Beschorner2.4.4. Lymphocytic hypophysitis and other inflammatory conditions of the pituitary, Mark E. Molitch and Jelena Kravarusic2.5. Pineal physiology and pathophysiology, including pineal tumours, Susan M Webb, Anna Aulinas, Cristina Colom, and José Barahona3. The Thyroid3.1. Evaluation of the thyroid patient3.1.1. The history and iconography relating to the thyroid gland, Robert Volpé and Clark Sawin3.1.2. Biosynthesis, transport, metabolism, and actions of thyroid hormones, W. Edward Visser3.1.3. Clinical assessment of the thyroid patient, Inge Bülow Pedersen and Stig Andersen3.1.4. Thyroid function tests and the effects of drugs, Ulla Feldt-Rasmussen3.1.5. Nonthyroidal illness syndrome, Robin P. Peeters and Anita Boelen3.1.6. Thyroid imaging: nuclear medicine techniques, Steen Bonnema and Laszlo Hegedüs3.1.7. Thyroid imaging: nonisotopic techniques, Laszlo Hegedüs and Finn N. Bennedbæk3.1.8. Epidemiology of thyroid disease and swelling, Mark P. J. Vanderpump3.2. Aetiology of thyroid disorders3.2.1. The complex genetics of thyroid disease, Terry Davies, Francesca Menconi, and Yaron Tomer3.2.2. Environmental factors, Josef Köhrle3.2.3. Iodine deficiency disorders, Michael B. Zimmermann3.2.4. Radiation-induced thyroid disease, Shunichi Yamashita, Furio Pacini, and Rossella Elisei3.2.5. Autoimmune thyroid disease, Anthony P. Weetman3.2.6. Thyroiditis, Elizabeth N. Pearce and Alan Farwell3.3. Thyrotoxicosis and related disorders3.3.1. Clinical assessment and systemic manifestations of thyrotoxicosis, Claudio Marcocci and Filomena Cetani3.3.2. Thyrotoxic periodic paralysis, Annie W. C. Kung and C.L. Cheung3.3.3. Thyrotoxic storm, Leonard Wartofsky, Dorina Ylli, and Joanna Klubo-Gwiezdzinska3.3.4. Subclinical hyperthyroidism, Simon Pearce3.3.5. Causes and laboratory investigations of thyrotoxicosis, Francesco Latrofa and Paolo Vitti3.3.6. Anti-thyroid drug treatment for thyrotoxicosis, Luigi Bartalena3.3.7. Radio-iodine treatment of hyperthyroidism, Markus Luster and Michael Lassmann3.3.8. Surgery for thyrotoxicosis, Nancy Dugal Perrier, Orlo Clark, and Sarah B. Fisher3.3.9. Management of Graves hyperthyroidism, Jacques Orgiazzi3.3.10. Graves orbitopathy and dermopathy, Wilmar M. Wiersinga3.3.11. Management of toxic multinodular goitre and toxic adenoma, Dagmar Führer and Holger Jäschke3.3.12. Management of thyrotoxicosis without hyperthyroidism, Wilmar M. Wiersinga3.4. Hypothyroidism3.4.1. Clinical assessment and systemic manifestations of hypothyroidism, Massimo Tonacchera and Luca Chiovato3.4.2. Causes and laboratory investigation of hypothyroidism, Ferruccio Santini3.4.3. Myxoedema coma, Leonard Wartofsky, Dorina Ylli, and Joanna Klubo-Gwiezdzinska3.4.4. Subclinical hypothyroidism, Bijay Vaidya and Chantal Daumerie3.4.5. Syndromes of Resistance to Thyroid Hormone, Mark Gurnell, Carla Moran, and V. K. Chatterjee3.4.6. Treatment of hypothyroidism, Birte Nygaard3.5. Thyroid lumps3.5.1. Pathogenesis of nontoxic goitre, Dagmar Führer and Holger Jäschke3.5.2. Management of nontoxic multinodular goitre, Hans Graf and Gilberto Paz Filho3.5.3. Management of the single thyroid nodule, Laszlo Hegedüs and Finn N. Bennedbæk3.5.4. Pathogenesis of thyroid cancer, Massimo Santoro, Barbara Jarzab, Jolanta Krajewska, and Dagmara Rusinek3.5.5. Pathology of thyroid cancer, Fulvio Basolo and Clara Ugolini3.5.6. Papillary, follicular, and anaplastic thyroid carcinoma and lymphoma, Corin Badiu and Ruxandra Dobrescu3.5.7. Medullary thyroid carcinoma, Friedhelm Raue and Karin Frank-Raue4. Parathyroid, calcium, and bone metabolism4.1. Parathyroid anatomy, hormone synthesis, secretion, action, and receptors, David Goltzman and Geoffrey N. Hendy4.2. Hypercalcaemia, Claudio Marcocci, Federica Saponaro, and Filomena Cetani4.3. Primary hyperparathyroidism, John P. Bilezikian4.4. Familial Hypocalciuric Hypercalcemia Types 1-3 and Neonatal Severe Primary Hyperparathyroidism, Dolores Shoback and Muriel Babey4.5. Hypocalcaemic disorders, hypoparathyroidism, and pseudohypoparathyroidism, Rajesh Thakker, Bart Clarke, and Fadil M. Hannan4.6. Bones and the Kidney—The Practical Conundrum: Distinguishing Between Osteoporosis and the Bone Diseases that Accompany Chronic Renal Failure, Paul D. Miller and Michael Pazianas4.7. Hypercalcaemic and hypocalcaemic syndromes in children, Laleh Ardeshirpour, Thomas O. Carpenter, and Cemre Robinson4.8. Osteoporosis, Richard Eastell4.9. Thyroid disorders and bone disease, Graham R. Williams, J. H. Duncan Bassett, Bernard Freudenthal, and Laura M. Watts4.10. Paget s disease of bone, Socrates E. Papapoulos4.11. Rickets and osteomalacia (acquired and heritable forms), Michael P. Whyte4.12. Glucocorticoid-induced osteoporosis, Gherardo Mazziotti, Ernesto Canalis, and John P. Bilezikian5. The adrenal gland and endocrine hypertension5.1. Adrenal imaging, Peter Guest5.2. Adrenal surgery, Fausto Palazzo and Radu Mihai5.3. Adrenal incidentaloma, Irina Bancos, Massimo Terzolo, and Wiebke Arlt5.4. Adrenocortical cancer, Jérôme Bertherat, Rossella Libè, and Anne Jouinot5.5.1. Genetics of phaeochromocytomas, paragangliomas, and neuroblastoma, Eamonn R. Maher and Ruth T Casey5.5.2. Management of phaeochromocytoma and paragagnlioma, Henri Timmers5.6.1. Genetics of primary aldosteronism and other steroid-related causes of endocrine hypertension, Maria Christina Zennaro, Fabio Fernandes-Rosa, and Sheerazed Boulkroun5.6.2. Management of primary aldosteronism, Morris Brown and Will Drake5.7. Cushing s syndrome, John Newell-Price5.8.1. Genetics of Adrenal Insufficiency, Li Chan and Shwetha Ramachandrappa5.8.2. Management of Adrenal Insufficiency, Wiebke Arlt5.9.1. Genetics of congenital adrenal hyperplasia, Nils P. Krone5.9.2. Modern management of congenital adrenal hyperplasia and prospects for the future, Richard J. Auchus6. Neuroendocrine tumours and genetic disorders6.1. Overview and Pathophysiology of Neuroendocrine Neoplasms, Guido Rindi and Rajaventhan Srirajaskanthan6.2. Neuroendocrine tumour markers, Whaljit Dhillo and Paul Bech6.3. Carcinoid syndrome , Rajaventhan Srirajaskanthan, Martyn E. Caplin, and Dominique Clement6.4.1. Lung neuroendocrine tumours, Juan W. Valle, Kok Haw Jonathan Lim, and Wasat Mansoor6.4.2. Non-functioning pancreatic neuroendocrine tumours, Juan W. Valle, Kok Haw Jonathan Lim, and Wasat Mansoor6.5. Gastrinoma, Christos Toumpanakis and Martyn E. Caplin6.6. Insulinoma and hypoglycaemia, Ashley Grossman and Ingrid YF Mak6.7. Glucagonoma, Karim Meeran6.8. Vasointestinal Polypeptide Secreting Tumours, Alia Munir6.9. Somatostatinoma, John Wass6.10. Imaging neuroendocrine tumours of the gastrointestinal tract/gastroenteropancreatic neuroendocrine tumours (GEP-NET), Prakash Manoharan6.11. Multiple endocrine neoplasia type 1, Rajesh V. Thakker6.12. Multiple endocrine neoplasia type 2a and 2b, Electron Kebebew, Douglas Wiseman, and Mustapha El Lakis6.13. Familial syndromes and genetic causes of paraganglioma and phaeochromocytoma , Eamonn R. Maher and Ruth T. Casey6.14. Carney s complex, Constantine A. Stratakis and Fabio Faucz6.15. Molecular and Clinical Characteristics Of the McCune-Albright Syndrome, Michael A. Levine and Steven A. Lietman6.16. Cowden syndrome, Charis Eng, Lamis Yehia, and Shreya Malhotra7. Growth and development during childhood and adolescence7.1. Growth and its Disorders7.1.1. Recognising Normal and Disordered Growth, Gary Butler7.1.2. Disorders of the GH-IGF Axis, Alexander A. L. Jorge, Fernanda A. Correa, and Renata C. Scalco7.1.3. Short stature in children born small for gestational age, Anita Hokken-Koelega7.1.4. Growth Disorders with no defined aetiology, Steve Chernausek and Minu George7.1.5. Tall Stature, Lars Savendahl and Emelie Benji7.2. Sex Development7.2.1. Sex Determination and Differentiation, Olaf Hiort and Ralf Werner7.2.2. Disorders of Sex Development (DSD) in the newborn, S. Faisal Ahmed and Salma R. Ali7.2.3. Recognising Normal and Disordered Pubertal Development, Alan Rogol and John Fuqua7.2.4. Pubertal Delay and Hypogonadism, Alan Rogol and John Fuqua7.2.5. Precocious Puberty, Julianne Leger and Jean-Claude Carel7.3. Transition In Endocrinology, Helena Gleeson and Rohana Wright8. Female endocrinology and pregnancy8.1. Normal female endocrinology and ovarian disorders8.1.1. Neuroendocrinology of reproduction: the role of hypothalamus and pituitary, Chris McCartney and John Marshall8.1.2. Ovarian and uterine development from fetal life to puberty, Terhi Piltonen and Juha Tapanainen8.1.3. Menstrual cycle and ovulation, Gurkan Bozdag, Baris Ata, and Engin Türkgeldi8.2. Evaluation of the female patient with suspected reproductive endocrine disorders8.2.1. Clinical evaluation of patient with suspected reproductive endocrine disorders, Channa Jayasena, Steve Franks, and Rachel Roberts8.2.2. Laboratory evaluation, Daniel Dumesic and Zain Al-Safi8.3. Reproductive endocrine disorders8.3.1. Disorders of gonadotrophin secreton, Sarah L. Berga8.3.2. Hyperprolactinaemia, Julian R. E. Davis and Agnieszka Swiecicka8.3.3. Premenstrual syndrome, Deepthi Lavu, Radha Indusekhar, and Shaughn O'Brien8.4. Polycystic ovary syndrome and other androgen excess disorders8.4.1. Polycystic ovary syndrome: definitions, phenotypes, prevalence and genetics, Bulent Yildiz and Sezcan Mumusoglu8.4.2. Polycystic ovary syndrome: reproductive aspects, R Jeffrey Chang8.4.3. Polycystic ovary syndrome: metabolic aspects, David Ehrmann and Susan Sam8.4.4. Polycystic ovary syndrome: Hirsutism, Duarte Pignatelli, Ricardo Azziz, and Bulent Yildiz8.5. Female hypogonadism and menopause8.5.1. Female hypogonadism: premature ovarian insufficiency, Ephia Yasmin and Gerard S. Conway8.5.2. Female hypogonadism: Endocrinology of the menopause and hormone replacement therapy, Dimitrios G. Goulis, Stavroula A. Paschou, and Panagiotis Anagnostis8.6. Female infertility8.6.1. Female Infertility and assisted reproduction, Adam Balen and Susie Jacob8.6.2. Female infertility: fertility preservation, Kutluk Oktay and Enes Taylan8.7. Hormonal contraception8.7.1. Hormonal contraception, Jennifer Chin Bliss Kaneshiro8.8. Exogenous factors and female repoductive health8.8.1. Exogenous factors and female reproductive health: common extragonadal endocrinopathies affecting reproduction, Alessandra Gambineri and Daniela Ibarra-Gasparini8.8.2. Exogenous factors and female reproductive health: nutrition and reproduction, Siew Lim, Aya Mousa, Soulmaz Shorakae, and Lisa Moran8.8.3. Exogenous factors and female reproductive health: envrionment and reproduction, Evy Diamanti-Kandarakis and Eleni A Kandaraki9. Endocrinology of pregnancy9.1. Endocrine disorders of Pregnancy9.1.1. General considerations relating to thyroid disease in pregnancy, Peter Taylor, LDKE Premawardhana, and John Lazarus9.1.2. Management of thyroid disorders before assisted and spontaneous pregnancy, Kris Poppe, Flora Veltri, and David Unuane9.1.3. Thyroid disease during pregnancy, Tim Korevaar and Robin Peeters9.1.4. Management of thyroid disorders after pregnancy, Nobuyuki Amino and Naoko Arata9.1.5. Thyroid disorders in newborns, infants and children, A. S. Paul van Trotsenburg Nitash and Zwaveling-Soonawala9.1.6. Pituitary tumours in pregnancy, Mark Molitch and Wenyu Huang9.1.7. Other disorders of the pituitary and hypothalamus in pregnancy, Paul Carroll, Niki Karavitaki, and Kirstie Lithgow9.1.8. Adrenal disease in pregnancy, David Torpy, Michael O'Reilly, and Sunita De Sousa9.1.9. Endocrine bone disease in pregnancy, Jeremy Cox and Stephen Robinson9.1.10. Imaging of endocrine disorders in pregnancy, Sandra Lowe10. Male Reproductive Endocrinology10.1. Normal male reproductive endocrinology10.1.1. Endocrine and local regulation of testicular hormone and sperm production, Ilpo Huhtaniemi and Jorma Toppari10.1.2. Sex steroid actions in the Male, Dirk Vanderschueren, Leen Antonio, Nari Kim, and Frank Claessens10.2. Evaluation of the male patient with suspected hypogonadism and/or infertility10.2.1. Clinical evaluation, Bradley Anawalt10.2.2. Endocrine evaluation, Jean-Marc Kaufman10.2.3. Diagnostic Semen analysis, Jackson Kirkman-Brown and Sarah J Conner10.3. Male reproductive endocrine disorders10.3.1. Klinefelter s syndrome, Claus H. Gravholt10.3.2. Adult Hypogonadism: Aetiology10.3.2.1. Etiology of Hypogonadism, Alvin Matsumoto and Radhika Narla10.3.2.2. Types of Treatments, Giovanni Corona, Mario Maggi, and Giulia Rastrelli10.3.2.3. Gonadotrophin induction of spermatogenesis, Michael Zitzmann10.3.2.4. Male Hypogonadism: Benefits of Testosterone Treatment, Shehzad Basaria and Thiago Gagliano-Juca10.3.2.5. Risks of T Treatment, Adrian Dobs and Swaytha Yalamanchi10.3.3. Management of Idiopathic male infertility, Herman J. Tournaye and Biljana Popovic-Todorovic10.3.4. Hypothalamo-pituitary-testicular axis fucntion in systemic diseases and effects of medications, Mathis Grossmann, B. Yeap, and Gary Wittert10.3.5. Management of sexual dysfunction, Vincenzo Rochira, Antonio R. M. Granata, and Cesare Carani10.3.6. Hormonal male contraception, Stephanie Page and Maritza Farrant10.3.7. Gynaecomastia, Glenn Braunstein10.4. Exogenous factors and male reproductive health10.4.1. Environmental influences on male reproductive health, Jorma Toppari10.4.2. Androgen Misuse and Abuse, David Handelsman11. Management of the Transgender Patient11.1. Introduction to Transgender and Gender Diverse People, Jon Arcelus and Walter Bouman11.2. Endocrine Treatment of Transgender Youth, Daniel Klink11.3. Hormone Therapy in transgender women, Vin Tangpricha and Craig Sineath11.4. Hormone therapy in transgender men, Guy T'Sjoen and Justine Defreyne11.5. Fertility Options for Transgender Persons , Chloë De Roo and Guy T'Sjoen12. Endocrine Responses to Systemic Diseases or Substance Use12.1. Endocrinology of systemic disease12.1.1. The endocrine response to stress, David Henley, Thomas Upton, and Stafford L. Lightman12.1.2. Endocrinology in the critically ill, Greet Van den Berghe and Lies Langouche12.1.3. Hormones and the kidney, David Johnson, Melissa Nataatmadja, and Yeoungjee Cho12.1.4. The endocrinology of liver disease, Jacob George and Mohammed Eslam12.1.5. Endocrine abnormalities in HIV infection, Steven K. Grinspoon and Takara Stanley12.1.6. The endocrinology of anorexia nervosa, Karen Miller12.2. Endocrine Complications of Substance Misuse 12.2.1. Endocrinology and alcohol, Marc Walter and Margit Proescholdt12.2.2. Use and abuse of performance-enhancing hormones in sport, Peter Sonksen and Richard Holt12.2.3. Effect of Opioids on Adrenal and Reproductive Endocrinology, Ashley Grossman, Eleni Armeni, and Bernard Khoo13. Endocrinology of cancer13.1. Endocrine Disorders Caused by Cancer or its Treatment13.1.1. Metastatic Disease in Endocrine Organs, Thomas Papathomas and Vania Nose13.1.2. Paraneoplastic endocrine syndromes, David W. Ray13.1.3. Long-term endocrine sequelae of cancer therapy, Claire Higham and Rob Murray13.1.4. Endocrine complications of biological cancer therapies, Carla Moran13.2. Hormonal therapy for breast and prostatic cancers13.2.1. The breast: lactation and breast cancer as an endocrine disease, Rob Clarke and Alice Greenhalgh13.2.2. Endocrine treatment of breast cancer, Amna Sheri and Laura Morrison13.2.3. Hormonal Therapy for Prostate Cancer: Molecular basis of efficacy and therapeutic bypass, Irina A. Vasilevskaya, Matthew J. Schiewer, and Karen E. Knudsen14. Obesity, lipids, and metabolic disorders14.1. Obesity14.1.1. The Physiology of Bodyweight Regulation, Anthony Coll14.1.2. Obesity as a Public Health Problem, Adrian Bauman14.1.3. Medical Complications of Obesity , Rachel Batterham and Friedrich Jassil14.1.4. Dietary and Medical Management of Obesity, John Wilding and Jonathan Lim14.1.5. Metabolic Surgery, Francesco Rubino, Vivian Anastasiou, Luca Ferraro, Dalal Qanaq, and Ghassan Chamseddine14.1.6. Assessment of Obesity in Children, Sadaf Farooqi14.1.7. Management of Obesity in Children and Young People, Russell Viner and Billy White14.1.8. Planning obesity care pathways, Nick Finer14.2. Lipoprotein metabolism and dyslipidaemia14.2.1. Lipoprotein metabolism, Bo Angelin and Paolo Parini14.2.2. Genetic forms of dyslipidaemia, Stefano Romeo, Bo Angelin, and Paolo Parini14.3. Other metabolic disorders14.3.1. Hyperinsulinaemic Hypoglycaemia, Khalid Hussain and Sonya Galcheva14.3.2. Autoimmune Hypoglycaemia , Phillip Gorden and Noemi Malandrino14.3.3. Disorders of carbohydrate metabolism, Robin H. Lachmann14.3.4. Haemochromatosis And Other Inherited Diseases Of Iron Metabolism, Yves Deugnier and Edouard Bardou-Jacquet14.3.5. The porphyrias, Michael N. Badminton and Danja Schulenburg-Brand15. Diabetes mellitus15.1. Introduction to Diabetes Mellitus15.1.1. Physiology of glucose homeostasis, Shanta Persaud and Peter Jones15.1.2. Classification and diagnosis of diabetes mellitus, Stephen Colagiuri and Crystal Man Ying Lee15.2. Aetiopathogenesis and Diagnosis of Type 1 Diabetes15.2.1. Epidemiology and Public Health, Elizabeth J. Mayer-Davis and Daria Igudesman15.2.2. Presentation and Natural History, Augustin Brooks15.2.3. Pathogenesis, Richard Oram, Susan Wong, and Ayat Bashir15.3. Aetiopathogenesis and Diagnosis of Type 2 Diabetes15.3.1. Epidemiology and Public Health, Sarah Wild and Jackie Price15.3.2. Presentation and Natural History, Roy Taylor15.3.3. Pathogenesis, Mark Walker, Xuefei Yu, and Amalia Gastaldelli15.4. Non Type 1, Non Type 2 Diabetes15.4.1. Diagnosis of non type 1, non type 2 forms of diabetes, Katherine Owen15.5. Principles of Management of Diabetes15.5.1. Structured Education, Simon Heller and Jackie Elliott15.5.2. Glucose Monitoring and Sensing, John Pickup and Nick Oliver15.5.3. Insulins and insulin delivery devices, Pratik Choudhary and Peter Jacob15.5.4. Non-insulin glucose lowering agents, Clifford Bailey and Melanie Davies15.5.5. Hypoglycaemia in the treatment of diabetes mellitus, Stephanie Amiel15.6. Evidence-based Management of Type 1 Diabetes15.6.1. Strategies for management of type 1 diabetes, Peter Hammond and Fiona Campbell15.6.2. Psychological and Behavioural Aspects of Type 1 Diabetes Management, Christel Hendrieckx and Jane Speight15.6.3. Immunotherapy for type 1 diabetes, Colin Dayan and Danijela Tatovic15.6.4. Transplantation (islet and solid organ), Peter Senior, Martin Drage, Anneliese Flatt, and Chris Callaghan15.7. Evidence-based Prevention and Management of Type 2 Diabetes15.7.1. Strategies for management of type 2 diabetes, Peter Winocour and Sagen Zac-Varghese15.7.2. Psychological and Behavioural Aspects of Type 2 Diabetes Management, Jane Speight and Tim Skinner15.7.3. Type 2 diabetes in different ethnic groups, Kamiesh Khunti and Nitin Narayan Gholap15.7.4. Prevention of Type 2 Diabetes, Nicholas Wareham15.8. Emerging Approaches to Restoring Euglycaemia in Diabetes15.8.1. Regenerative medicine for diabetes, Michael White, Timothy J. Kieffer, and Cara Ellis15.8.2. Closed loop, Roman Hovorka and Charlotte Boughton15.9. Emergency and Hospital management of Diabetes15.9.1. Hyperglycaemic Emergencies, Ketan Dhatariya15.9.2. Management of the inpatient with diabetes mellitus, Gerry Rayman15.9.3. Care of diabetes in ICU and peri-sugery, Greet Van Den Berghe and Jan Gunst15.10. Specialised Management of Other forms of Diabetes15.10.1. Monogenic forms of diabetes resulting from beta cell dysfunction, Andrew Hattersley, Kashyap Patel, and Rachel Besser15.10.2. Lipodystrophies and severe insulin resistance, Anna Stears, David B. Savage, and Stephen O'Rahilly15.10.3.1. Diabetes Secondary to Pancreatic Disease, Phil Weston15.10.3.2. Diabetes Secondary to Endocrine Disorders, Jeremy Tomlinson15.10.4. Diabetes in Pregnancy, Helen Murphy and Jennifer M Yamamoto15.11. Psychiatry and Diabetes15.11.1. Type 1 diabetes and Psychiatry, Khalida Ismail, Christopher Garrett, and Marietta Stadler15.11.2. Type 2 diabetes and Psychiatry, Khalida Ismail, Hermione Price, Marilia Calcia, Calum Moulton, and Clare Whicher15.12. Microvascular Complications of Diabetes15.12.1. Pathogenesis of Microvascular Complications, Angela Shore15.12.2. Retinopathy, Peter Scanlon15.12.3. Diabetic Nephropathy, Luigi Gnudi and Sally Marshall15.12.4. Diabetic Neuropathy, Solomon Tesfaye and Jing Wu15.13. Macrovascular Disease in Diabetes15.13.1. Mechanisms of macrovascular disease in diabetes, Mark Kearney, Peysh Patel, and Richard Cubbon15.13.2. Macrovascular disease in type 2 diabetes, Naveed Sattar15.13.3. Macrovascular disease in type 1 diabetes, John Petrie15.13.4. Diabetic dyslipidaemia, Bruno Vergès15.13.5. Hypertension in diabetes mellitus, Bryan Williams15.14. The Diabetic Foot15.14.1. Modern management of diabetes-related foot disease, Frank Bowling and Andrew Boulton15.15. Delivery of Diabetes Care15.15.1. Diabetes service organisation, Jonathan Valabhji15.15.2. Health Economics of Diabetes Care and Prevention, Philip Clarke and Tom Lung

Editorial Reviews

Reviewer: Celeste C Thomas, MD (University of Chicago Medical Center)
Description: In addition to providing algorithms on common clinical questions in endocrinology, this book also provides historical references. It updates the 2002 first edition.
Purpose: The purpose is to provide an updated reference on complex endocrine issues.
Audience: It appears to be targeted at specialists in the field of endocrinology, including fellows in training and attending clinicians. Medical students and internal medicine residents also may use it as a reference, though it may be too specific for their purposes.
Features: The book broadly and intensively covers the field of endocrinology with 13 parts appropriately dividing the subject matter based on anatomical system, gender, and age. It includes a great deal of information on congenital, child, and adolescent disorders in addition to adult disorders and can serve as a general reference in both pediatric and adult endocrinology. The authors should be commended for their commitment to detail and the excellent reference lists in each section. A well-constructed index is important in this type of book, and this one is comprehensive and easy to use. The book would benefit from additional color art, especially in many of the illustrations.
Assessment: This is an excellent quality reference that serves an important role in endocrinology.

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