P-450 and Chemical Carcinogenesis

by Yusaku Tagashira

Overview

This book is one of a GANN Monograph on Cancer Research series and is based on a Japanese Cancer Association-sponsored symposium entitled "Multiplicity of Chemical Carcinogen-Activating Enzymes· with Particular Emphasis on Cyhrome P-450" which was held in Tokyo on November 21, 1983. The principal role of microsomal cyhrome P-450 in the metabolic activation of various chemical carcinogens in animal cells has been well established. The activated chemical carcinogens induce mutations of the cells, which is an essential part of the initiation of chemical carcinogenesis. Since microsomal cyhrome P-450 in various animal tissues includes multiple molecular species with different substrate specificities and different responses to chemical inducers, knowledge of the molecular and catalytic properties and the inducibilities of those cyhrome P-450 forms is surely a most important base from which to elucidate the mechanism of chemical carcinogenesis. The focus of the symposium was this area of molecular diversity and inducibility of microsomal cyhrome P-450 in animal tissues. The mechanism of activation of various types of chemical carcinogens by cyhrome P-450 and related enzymes was another main topic. The editors, who were also the symposium organizers, hope these summaries of current research in this field in Japan will stimulate future development of studies on the mechanism of chemical carcinogenesis.

Product Details

ISBN-13:	9781468450323
Publisher:	Springer US
Publication date:	03/30/2012
Edition description:	Softcover reprint of the original 1st ed. 1985
Pages:	176
Product dimensions:	7.01(w) x 10.00(h) x 0.02(d)

Table of Contents

I. Molecular Multiplicity of Cyhrome P-450.- Physicochemical Properties of Multiple Forms of Cyhrome P-450: A Proposal for the Ligand Structure.- Characteristics of Purified Cyhrome P-450s in Microsomes of Rat Lung and Morris Hepatoma 5123D.- Localization of Cyhrome P-450 in Rat Liver Nuclei: Its Possible Significance in the Chemical Carcinogenesis.- Microsomal Cyhrome P-450 in Higher Plants.- II. Activation of Carcinogenic Compounds by Cyhrome P-450.- Metabolic Activation of Chemical Carcinogens by Two Molecular Species of Cyhrome P-450.- Activation of Carcinogenic Compounds by Purified Cyhrome P-450 in Reconstituted Systems.- Mechanism of Metabolic Activation of Carcinogenic Aromatic Amines.- Mechanism of Metabolic Activation of Aflatoxin B1.- Metabolic Activation of 7,12-Dimethylbenz[a]anthracene and 7-Methylbenz[a] anthracene via Hydroxymethyl Sulfate Esters by P-450-sulfotransferase.- III. Induction and Genetics of Cyhrome P-450.- Induction of Microsomal Cyhrome P-450 in Rat Liver by Chemical Com­pounds.- Molecular Multiplicity and Gene Structure of Microsomal Cyhrome P-450 in Rat Liver.- Author Index.