Paradigms of Neural Injury

by Elsevier Science

Overview

This volume includes paradigms, model systems, and techniques for the study of dysfunctions in the nervous system. The advantages and disadvantages of the approaches presented are critically discussed.

• Neural injury
• Developmental cell death
• Disease processes and aging

Product Details

ISBN-13:	9780080536484
Publisher:	Elsevier Science
Publication date:	05/23/1996
Series:	ISSN , #30
Sold by:	Barnes & Noble
Format:	eBook
Pages:	335
File size:	8 MB

About the Author

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.

Table of Contents

Paradigms for Study of Neurotrophin Effects in Oxidant Injury, G.R. Jackson and J.R. Perez-Polo.
Nitric Oxide Toxicity in Central Nervous System Cultures, V.L. Dawson and T.M. Dawson.
Development of in Vitro Injury Models for Oligodendroglia, A. Espinosa, P. Zhao, and J. de Vellis.
Glia Models to Study Glial Cell Cytotoxicity, A. Vernadakis and M.S. Kentroti.
Rodent Glioma Models, W.W. Maggio.
Peripheral Lesioning of Olfacory System: Expression of Neurotrophin Receptors, C.P. Turner and J.R. Perez-Polo.
Basal Forebrain Cholinergic Lesions and Complete Transection of Septal-Hippocampal Pathway, L.R. Williams.
Neurochemical Lesions: Tools for Functional Assessment of Serotonin Neuronal Systems, J.M. Lakoski, B.J. Keck, and A. Dugar.
Cerebral Glucose/Energy Metabolism: Valid Techniques in Humans and Animals, S. Hoyer.
Heavy Metal Effects on Glia, E. Tiffany-Castiglioni, M.E. Legare, L.A. Schneider, E.D. Harris, R. Barhoumi, J. Zmudzki, Y. Qian, and R.C. Burghardt.
Source, Metabolism, and Function of Cysteine and Glutathione in the Central Nervous System, D.K. Rassin.
Magnetic Resonance Spectroscopy of Neural Tissue, R.J. McClure, K.Panchaligam, W.E. Klunk, and J.W. Pettegrew.
Acute Stroke Diagnosis with Magnetic Resonance Imaging, S.C. Jones, N.C. Huang, M.J. Quast, A.D. Perez-Trepechio, G.R. Hillman, and T.A. Kent.
Evaluation of Free Radical-Initiated Oxidant Events within the Nervous System, S.C. Bondy.
Exogenous Administration of Cytokines into the Central Nervous System: Analysis of Alterations in Cell Morphology and Molecular Expression, M.A. Kahn and J. de Vellis.
Animal Models to Produce Cortical Cholinergic Dysfunction, R. Schliebs and V. Bigl.
In Vitro Studies of Liposome-Mediated Gene Transfection, K. Yang, J.R. Perez-Polo, F. Faustinella, G. Taglialatela, and R.L. Hayes.
Construction and Analysis of Transgenic Mice Expressing Amyloidogenic Fragments of Alzheimer Amyloid Protein Precursor, R.L. Neve and F.M. Boyce.
Golgi Technique Used to Study Stress and Glucocorticoid Effects on Hippocampal Neuronal Morphology, A.M. Magarinos, E. Fuchs, G. Flügge, and B.S. McEwin.
Index.

Editorial Reviews

Reviewer: Alexander Kolchinsky, PhD (University of Illinois at Chicago College of Medicine)
Description: The book consists of 19 chapters written by 48 authors on different experimental aspects of neural injury.
Purpose: The goal is to provide researchers with clear presentations of adequate models of neural injury and critical reviews of relevant techniques.
Audience: The potential audience is not outlined, but apparently it is intended for researchers in the biomedical field.
Features: Although the book is not subdivided, the chapters can be arbitrarily grouped into in vitro models based on cells in culture (4 chapters), in vivo models based mostly on surgical or chemical damage of rat brain (7 chapters); sophisticated techniques to study neural injury, including sensitive chemical analyses and magnetic resonance (6 chapters); and two chapters on molecular genetics. Some chapters discuss factors of neural injury that are considered to be the most important in clinical settings. These include cholinergic and serotoninergic lesions, effects of heavy metals, detailed assessment of metabolism involving glucose and other energy sources, and SH-compounds.
Assessment: In the preface, the editor calls the book "eclectic," and this is an understatement. Some chapters contain technical description of methods or slightly modified research papers. Nevertheless, valuable and well-compiled reviews can be found here as well (glioma models; chapters on magnetic resonance; chapters describing chemical analyses; and others). A reader with general interest in the field will be lost, because the book does not contain any overview of the problem or even a short introduction to present individual chapters from a more general viewpoint. The book enables a researcher to assess a complicated approach and sometimes to find a protocol for its application. It will remain mostly on the shelves of big academic libraries. The format of chapters is inconsistent; some chapters definitely need more schemes and especially color illustrations.

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