Particle-Lung Interactions / Edition 2

by Peter Gehr, Christian Mühlfeld, Barbara Rothen-Rutishauser, Fabian Blank

Overview

Written by an expanded team of leading international scientists, the second edition thoroughly investigates research and therapies for managing adverse physiological effects of air-borne particles on the respiratory tract. The book examines the lung as the gateway for particle damage to organs outside the respiratory system and provide the information needed to understand and combat the numerous and varied ailments caused by inhaled particles.

Product Details

ISBN-13:	9781420072563
Publisher:	Taylor & Francis
Publication date:	09/25/2009
Series:	Lung Biology in Health and Disease , #241
Edition description:	2nd ed.
Pages:	344
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

Peter Gehr, University of Berne, Switzerland. Christian Mühlfeld, University of Giessen, Germany. Barbara Rothen-Rutishauser, University of Berne, Switzerland. Fabian Blank University of Berne, Switzerland.

Table of Contents

Introduction Preface Part 1: Structure and Function of the Lung 1. Functional Aspects of Lung Structure as Related to Interaction with Particles Part 2: Particle Characteristics2. Ambient Tropospheric Particles 3. Manufactured Nanoparticles 4. Particulate Carriers for Pulmonary Drug Delivery Part 3: Inhalation of Particles 5. Deposition, Retention and Clearance, and Translocation of Inhaled Fine and Nano-Sized Particles in the Respiratory Tract Part 4: Health Effects of Particle Inhalation6. The Epidemiology of Particle Health Effects 7. Cardiovascular Consequences of Particles 8. Autonomic Mediation of the Cardiac Responses to Particle Exposure 9. Effects of Airborne Particles on Respiratory Viral Infection 10. Airborne Particles and Structural Remodeling of the Lungs Part 5: Cellular and Molecular Mechanisms of Particle Health Effects 11. Effect of Particles on Mucus and Mucociliary Clearance 12. The Role of Surfactant in Particle Exposure 13. Nanoparticle–Cell Membrane Interactions 14. Mechanisms and Processes Underlying Toxicological Responses to Particles 15. Aeroallergen-Lung Interactions 16. Dose-Response Relationships

Editorial Reviews

3 Stars from Doody

Anyone working in one of the areas covered by this volume will find it a useful and indeed enjoyable to book to read.

Indoor and Built Environment

...strongly recommend[ed] that those researchers routinely working in the field of aerosol therapy acquire this book and that others with a peripheral interest consider this a valuable reference text.

Pharmaceutical Research

...covers a fascinating scientific spectrum....smartly structured....up-to-date review of particle-lung.

Respiratory Care

...strongly recommend[ed] that those researchers routinely working in the field of aerosol therapy acquire this book and that others with a peripheral interest consider this a valuable reference text.

Research Pharmaceuti

This is a concise, up-to-date source for anyone interested in the field of particle-lung interactions. It provides an overview of environmental, occupational, and medicinal particles, with biological responses discussed after disposition and deposition of particles in the lung. This volume should be of great value to any researchers monitoring the increase in asthma and the role that particles may play in this increase. The overview and the occupational and environmental sections are very well written. The section on molecular and cellular responses to inhaled particles is the best that I have read to date. Also, the systemic response and health consequence sections are well thought out. This book represents the ""go to"" source of information for me when I need up-to-date information in the particle and lung interaction area. It is a very well thought out, up-to-date, and concise source of coverage in all areas in this field. To my knowledge, there are no other sources that are available to date that cover so broad an area so well.

Daniel M. Laskowski

This reference presents the latest developments in aerosol science and interactions between particles and the respiratory tract. Specifically, the focus is on the dynamics of particle deposition, retention, and clearance. The editors take an interdisciplinary approach, drawing from physics, chemistry, engineering, and epidemiology. Topics discussed include: therapeutic and diagnostic aspects of particle inhalation, stereological estimation of particle retention, the correlation between particulate air pollution and cardiovascular mortality, and particle-surfactant interaction. Peter Gehr is Professor and the Head of the Division of Histology at the Institute of Anatomy at the University of Bern, Switzerland. Joachim Heyder is Professor and the Director for the Institute of Inhalation Biology at the GSF-National Research Center for Environment and Health, Neuherberg/Munich, Germany. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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