Practical Immunopathology of the Skin

by Bruce R. Smoller

Overview

Bruce R. Smoller, md, concisely reviews for practitioners and students alike the science of immunopathology, its many basic laboratory tools, and their multiple diagnostic uses in actual clinical case studies. The author presents in an easily digestible form a dictionary of antibody probes, summarizing for each antibody the targeted antigen and its cellular function, its diagnostic utility, and, when available, its sensitivities and specificities for identifying various neoplasms. Real clinical cases from the author's practice demonstrate the benefits of immunopathology.

Product Details

ISBN-13:	9781592593392
Publisher:	Springer-Verlag New York, LLC
Publication date:	08/23/2002
Series:	Current Clinical Pathology
Sold by:	Barnes & Noble
Format:	eBook
Pages:	208
File size:	12 MB
Note:	This product may take a few minutes to download.

Table of Contents

I. Introduction.- 1 Overview.- 2 Immunoperoxidase: The Technique.- II. Antibody Directory.- 3 Epithelial Markers.- 4 Mesenchymal Markers (Nonhematopoietic).- 5 Hematopoietic Markers.- 6 Melanocyte Markers.- 7 Neuroectodermal (Other than Melanocytic) and Neuroendocrine Markers.- 8 Antibodies Used to Identify Infectious Diseases.- 9 Markers Useful in Detecting Metastatic Disease.- III. Vignettes.- 10 Vignettes.

Editorial Reviews

3 Stars from Doody

Reviewer: Patricia Wong, MD (Private Practice)
Description: This is a concise presentation of immunopathological techniques used to identify cellular antigens and hence cellular origin. It is probably the clearest and most painless explanation I have read on the subject. Novices will enjoy reading the book.
Purpose: The purpose of the book is to aid dermatopathologists and dermatologists in evaluating histopathology in which the diagnosis is not clear on plain microscopic examination. The limitations and potential errors of immunopathology are discussed. The author is careful to point out that these immunomarkers are not predictors of tumor behavior (benign or malignant) but should be interpreted in the clinical and histologic context.
Audience: The audience is pathologists and dermatologists. Residents in these specialties will also want to study this book. The author is a very good teacher and the material is presented in a digestible manner.
Features: Black-and-white micrographs of tissue staining with various antibodies are included, but color photographs would have been better. As a nonpathologist not used to looking at these stains, I found it a little hard to tell what was being stained in the photographs. There are helpful flow charts suggesting workups for undifferentiated spindle cell tumors, lymphocytic infiltrates, etc. I wish that a glossary had been included defining some of the pathology terms. The author assumes that one is already knowledgeable in this arena. I could not figure out what a Toker cell was, even when I looked in a major textbook like Lever's Histopathology of the Skin, 8th edition, Elder et al.(Lippincott Williams & Wilkins, 1997).
Assessment: This book contains the best discussion on the subject and I would recommend it as a requirement for dermatologists and pathologists. This field has become more and more technical and understanding this subject is a necessity for anyone dealing with skin pathology.

Doody's Review Service

"This book contains the best discussion on the subject and I would recommend it as a requirement for dermatologists and pathologists. This field has become more and more technical and understanding this subject is a necessity for anyone dealing with skin pathology" - Doody's Health Sciences Book Review Journal

"The book fulfills its stated aim of providing dermatologists, in training or active practice, with a working repertoire of useful antibodies. Those reporting dermatopathology from a general histopathology background will come across few surprises, but will still find it valuable to savor and learn from an international expert in dermatopathology." - ACP News

"Residents in dermatology and pathology, clinicians, and practicing pathologists and dermatopathologists all will find this book valuable and highly instructive." - SkinMed

From the Publisher