Principles of Molecular Cardiology / Edition 1

by Marschall S. Runge, Cam Patterson

Overview

An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.

Product Details

ISBN-13:	9781627038072
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/25/2014
Series:	Contemporary Cardiology
Edition description:	2005
Pages:	617
Sales rank:	884,074
Product dimensions:	8.27(w) x 10.98(h) x 0.05(d)

Table of Contents

Overview.- Cardiovascular Genetics.- Molecular Biology Applications in Cardiovascular Medicine.- Genomics and Its Application to Cardiovascular Disease.- Gene Therapy and Cardiovascular Diseases.- Stem Cells and Progenitor Cells in Cardiovascular Disease.- Myocardial Disease.- Development of the Vertebrate Heart.- Inherited Myocardial Diseases.- Receptor-Signaling Pathways in Heart Failure.- Recent Insights into the Molecular Pathophysiology of Viral Myocarditis.- Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease.- Coronary Artery Disease.- Coronary Artery Development.- Atherosclerosis.- Antiplatelet Drugs.- Myocardial Infarction.- Transplant Arteriopathy.- Thrombolysis.- Coronary Restenosis.- Arrhythmias.- Induction and Patterning of the Purkinje Fiber Network.- Mechanisms of Sudden Cardiac Death.- Gene Therapy for Cardiac Arrhythmias.- Genetics and Arrhythmias.- Vascular Diseases.- Therapeutic Angiogenesis for Ischemic Vascular Disease.- Nitric Oxide in Cardiovascular Biology and Pathophysiology.- Vasculitis.- Primary Pulmonary Hypertension.- The Molecular Basis of Cerebrovascular Malformations.- Thrombotic Vascular Disease.- Risk Factors.- Risk Factors.- Vascular Aging.- Oxidative Stress.- Diabetes Mellitus.- Vascular Inflammation as a Cardiovascular Risk Factor.

Editorial Reviews

From the Foreword...
"I believe that this is an outstanding book. Anyone interested in the development, genetics, and pathologies that affect the cardiovascular system will want to have Principles of Molecular Cardiology available for ready reference." -James T. Willerson, MD

From the reviews:

"...should be in any pediatric library, not to say cardiac departments." - Pediatric Endocrinology Reviews

"This book … provides a broad and up-to-date treatment of molecular biology of cardiovascular diseases. Certainly this book shows quite thoroughly the direction in which cardiology is moving." (American Journal of Cardiology, December, 2005)

"...shows quite thoroughly the direction in which cardiology is moving." -American Journal of Cardiology

From the Publisher

Reviewer: Keith G Hickey, MD, BS (Ochsner Clinic Foundation)
Description: This book explores the latest developments in molecular cardiology research covering the molecular basis of cardiovascular diseases.
Purpose: The purpose is to discuss the molecular biology of cardiovascular diseases. This book provides overviews of the major themes in molecular cardiology, including cardiac function, coronary artery disease, arrhythmias, vascular diseases and risk factors. The authors make these complex topics easy to understand.
Audience: This book is intended for clinicians, scientists, students, and healthcare professionals who want to keep abreast of current findings in molecular cardiology research. The authors are all leading specialists in their fields.
Features: The book is divided into six sections, which are subdivided into chapters, beginning with a historical overview of the major themes in molecular cardiology: genetics, the molecular biology of the cardiovascular system, genomics and gene therapy and stem cells in cardiovascular disease. The next part covers cardiac function and dysfunction, including inherited diseases such as hypertrophic cardiomyopathies and muscular dystrophies that affect the heart. Part three addresses coronary artery disease. Section four on cardiac arrhythmias is timely given the recent progress in understanding the molecular basis and genetics of ventricular arrhythmias and sudden death. This is followed by a section on vascular diseases, which contains state-of-the art chapters on the molecular events that regulate angiogenesis. The book concludes with an excellent section on risk factors, summarizing the molecular basis of lipid metabolism, the biology of aging and the consequences of diabetes. Throughout each section several chapters are dedicated to treatment strategies which clinicians will find relevant. These chapters have excellent tables, photomicrographs, and figures that help illustrate concepts and aid understanding of the text.
Assessment: The authors have written a unique book that examines the latest developments in molecular cardiology and successfully provides a glimpse of what the future in molecular cardiology research holds. Understanding the molecular basis of cardiovascular diseases is no longer reserved for the basic scientist. Clinicians and healthcare professionals will need a working knowledge of the cellular and molecular pathogenetic mechanisms of cardiac diseases, because their treatment will require application of these advances.

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