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Protein Secretion in Bacteria
![Protein Secretion in Bacteria](http://img.images-bn.com/static/redesign/srcs/images/grey-box.png?v11.9.4)
Protein Secretion in Bacteria
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Overview
Protein Secretion in Bacteria, authored and edited by an international team of experts, draws together the many distinct functions and mechanisms involved in protein translocation in one concise tome. This comprehensive book presents updated information on all aspects of bacterial protein secretion encompassing:
- Individual secretory systems–Sec, Tat, and T1SS through the newly discovered T9SS
- Mechanisms, structures, and functions of bacterial secretion systems
- Lipoprotein sorting pathways, outer membrane vesicles, and the sortase system
- Structures and roles of surface organelles, including flagella, pili, and curli
- Emerging technologies and translational implications
Protein Secretion in Bacteria serves as both an introductory guide for students and postdocs and a ready reference for seasoned researchers whose work touches on protein export and secretion. This volume synthesizes the diversity of mechanisms of bacterial secretion across the microbial world into a digestible resource to stimulate new research, inspire continued identification and characterization of novel systems, and bring about new ways to manipulate these systems for biotechnological, preventative, and therapeutic applications.
About the Author
Eric Cascales, CNRS Aix-Marseille Université, Mediterranean Institute of Microbiology, Marseille, France.
Peter J. Christie, Department of Microbiology and Molecular Genetics, McGovern Medical School, Houston, Texas.
Table of Contents
ForewordPreface
Contributors
1 Electron Cryotomography of Bacterial Secretion SystemsCatherine M. Oikonomou and Grant J. Jensen
2 SecA-Mediated Protein Translocation through the SecYEG ChannelAmalina Ghaisani Komarudin and Arnold J.M. Driessen
3 The Two Distinct Types of SecA2-Dependent Export SystemsMiriam Braunstein, Barbara A. Bensing, and Paul M. Sullam
4 The Conserved Role of YidC in Membrane Protein BiogenesisSri Karthika Shanmugam and Ross E. Dalbey
5 The Twin-Arginine Pathway for Protein SecretionKelly M. Frain, Jan Maarten van Dijl, and Colin Robinson
6 Lipoproteins and Their Trafficking to The Outer MembraneMarcin Grabowicz
7 Protein Secretion in SpirochetesWolfram R. Zückert
8 Outer Membrane Protein Insertion by the β-barrel Assembly MachineDante P. Ricci and Thomas J. Silhavy
9 The TAM: A Translocation and Assembly Module of the β-barrel Assembly Machinery in Bacterial Outer MembranesChristopher J. Stubenrauch and Trevor Lithgow
10 The Dynamic Structures of the Type IV PilusMatthew McCallum, Lori L. Burrows, and P. Lynne Howell
11 Gram-Positive Type IV Pili and CompetenceSandra Muschiol, Marie-Stephanie Aschtgen, Priyanka Nannapaneni, and Birgitta Henriques-Normark
12 The Remarkable Biomechanical Properties of the Type 1 Chaperone-Usher Pilus: A Structural and Molecular PerspectiveManuela K. Hospenthal and Gabriel Waksman
13 Therapeutic Approaches Targeting the Assembly and Function of Chaperone-Usher PiliJohn J. Psonis and David G. Thanassi
14 Curli Biogenesis: Bacterial Amyloid Assembly by the Type VIII Secretion PathwaySujeet Bhoite, Nani van Gerven, Matthew R. Chapman, and Han Remaut
15 Sortases, Surface Proteins, and Their Roles in Staphylococcus aureus Disease and Vaccine DevelopmentOlaf Schneewind and Dominique Missiakas
16 Architecture and Assembly of Periplasmic FlagellumYunjie Chang and Jun Liu
17 Outer Membrane Vesicle-Host Cell InteractionsJessica D. Cecil, Natalie Sirisaengtaksin, Neil M. O’Brien-Simpson, and Anne Marie Krachler
18 Type I Secretion Systems—One Mechanism for All?Olivia Spitz, Isabelle N. Erenburg, Tobias Beer, Kerstin Kanonenberg, I. Barry Holland, and Lutz Schmitt
19 Architecture, Function, and Substrates of the Type II Secretion SystemKonstantin V. Korotkov and Maria Sandkvist
20 The Injectisome, A Complex Nanomachine for Protein Injection into Mammalian CellsMaria Lara-Tejero and Jorge E. Galán
21 Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence TargetAlyssa C. Fasciano, Lamyaa Shaban, and Joan Mecsas
22 Biological and Structural Diversity of Type IV Secretion SystemsYang Grace Li, Bo Hu, and Peter J. Christie
23 Hostile Takeover: Hijacking of Endoplasmic Reticulum Function by T4SS and T3SS Effectors Creates a Niche for Intracellular PathogensApril Y. Tsai, Bevin C. English, and Renée M. Tsolis
24 Type V Secretion in Gram-Negative BacteriaHarris D. Bernstein
25 Bordetella Filamentous Hemagglutinin, A Model for the Two-Partner Secretion PathwayZachary M. Nash and Peggy A. Cotter
26 Structure and Activity of the Type VI Secretion SystemYassine Cherrak, Nicolas Flaugnatti, Eric Durand, Laure Journet, and Eric Cascales
27 Type VI Secretion Systems and the Gut MicrobiotaMichael J. Coyne and Laurie E. Comstock
28 ESX / Type VII Secretion Systems–An Important Way Out for Mycobacterial ProteinsFarzam Vaziri and Roland Brosch
29 Bacteroidetes Gliding Motility and the Type IX Secretion SystemMark J. McBride
30 Similarities and Differences between Colicin and Filamentous Phage Uptake by Bacterial CellsDenis Duché and Laetitia Houot
31 A Hybrid Secretion System Facilitates Bacterial Sporulation: A Structural PerspectiveNatalie Zeytuni and Natalie C.J. Strynadka
Index