Protein Turnover and Lysosome Function

by Harold L. Segal (Editor), Darrell J. Doyle (Editor)

Overview

Protein Turnover and Lysosome Function comprises the proceedings of a symposium under the same title held at the State University of New York at Buffalo on August 21-26, 1977. The book discusses mechanisms of protein turnover, as well as the identification and characterization of intracellular proteases. The text also describes the internalization of macromolecules into the intracellular digestive system; the types of specificity entailed; and the fate of the membrane material involved in the vacuolization process. Biochemists, pathologists, cell biologists, molecular biologists, and physiologists will find the book invaluable.

Product Details

ISBN-13:	9781483220192
Publisher:	Elsevier Science & Technology Books
Publication date:	06/28/2014
Sold by:	Barnes & Noble
Format:	eBook
Pages:	810
File size:	16 MB
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Table of Contents

List of ContributorsPrefaceIntroductionMechanisms and Regulation of Protein Turnover Factors Involved in the Regulation of Protein Turnover Lysosomal Mechanisms of Protein Degradation Some Aspects of the Intracellular Breakdown of Exogenous and Endogenous Proteins Evidence for a Proton Pump in Rat Liver Lysosomes Lysosomal Processing of Intracellular Protein in Rat Liver and Its General Regulation by Amino Acids and Insulin In Vivo Determination of Rates of Protein Degradation in Livers of Meal-Fed Rats: Implications of Amino Acid Compartmentation The General Characteristics of Intracellular Protein Degradation in Diabetes and Starvation The Significance of Protein Degradation in the Regulation of Liver Growth Turnover of the Major Proteins of Rat Erythrocytes Mode of Degradation of Abnormal Globin Chains in Rabbit Reticulocytes Selective Degradation of Abnormal Proteins in Animal and Bacterial Cells Mechanisms in Intracellular Turnover of Stable and Labile Enzymes Studies on Protein Degradation in Isolated Hepatocytes and Kupffer Cells The Chemistry and Turnover of Lysosomal Enzymes Genetics of Lysosomal Functions Measurement of Protein, Synthesis and Turnover in Animal Cells with Tritiated Water Turnover of Soluble Protein in Growing Cultures of Escherichia coli Lysosomal and Nonlysosomal Proteases Lysosomal Proteinases and Their Specificity Control of Proteolysis in Yeast Collagenolytic Activity of Lung BANA Hydrolase and Cathepsin B1 Modification of Fructose 1,6-Bisphosphatase by Lysosomal Proteinases Bovine Spleen Cathepsins D and S: Purification, Characterization, and Structural Studies Characterization of Two Unique Protease Inhibitors and a Calcium-Activated Protease from Bovine Cardiac Muscle Protein Catabolism in Rat Liver Cells Uptake of Proteins into the Lysosomal System Lysosomal Digestion of Endoctosed Proteins: Opportunities and Problems for the Cell Uptake and Degradation of Proteins in Isolated Rat Liver Cells Protein Turnover in Isolated Rat Hepatocytes Receptor-Mediated Uptake of Macromolecules and Their Delivery to Lysosomes in Human Fibroblasts Specific Recognition and Uptake of Lysosomal Enzymes and Modified Glycoproteins by Rat Tissues Phosphohexose on Lysosomal Enzymes is the Common Recognition Marker for Pinocytosis Receptor on Fibroblasts A Role for Lysosomes in Corpus Luteum Function The Use of Lipid Vesticles for Introducing Macromolecules into Cells The Inhibitory Effect of 2-Deoxy-D-glucose on Fc and C3b Receptor-Mediated Phagocytosis in Phagocytic Cells Protein Turnover in Muscle and Heart A Ca2+-Activated Muscle Protease in Myofibrillar Protein Turnover Cathepsins B and D: Proteolytic Activity and Ultrastructural Localization in Skeletal Muscle Inhibition of Muscle Degeneration Using Protease Inhibitors Partial Characterization of a Protease from Cardiac Myofibrils of Dystrophic Hamsters Factors Affecting Protein Breakdown in Skeletal Muscle Changes in the Turnover Rates of Myosin Heavy Chain and Actin in Cultured Chick Embryo Heart Cells Studies on the Regulation of Protein Concentrations in Red and White Skeletal Muscles Turnover of Membrane Proteins Turnover and Biogenesis of the Plasma Membrane Proteins of Hepatoma Tissue Culture Cells A Shuttle between Cell Surface and Lysosomes during Endocytosis Turnover of Plasma Membrane Precursor Pools in Virus-Infected and Uninfected HeLa Cells Regulation of Insulin and Growth Hormone Receptors in Vitro and in Vivo Turnover of Proteins and Glycoproteins of Plasma Membranes in Liver, Regenerating Liver, and Morris Hepatomas