Pulmonary Surfactant: Biochemical, Functional, Regulatory, and Clinical Concepts / Edition 1

by Jacques R. Bourbon

Overview

This book represents a comprehensive update on pulmonary surfactant by merging classical knowledge with new information. Topics include surfactant secretion and alveolar processing and recycling; physical bases and different theoretical models of the physiological mechanism for pulmonary surfactant action; recent findings on surfactant-like material in other organs; developmental processes and multifactorial regulation; etiology and physiopathology of neonatal respiratory distress; and modern methods for functional explorations of the lung in neonates and experimental models in animals. The book also contains a discussion on the management of hyaline membrane disease, from both the experimental and clinical points of view.

Product Details

ISBN-13:	9780849369247
Publisher:	Taylor & Francis
Publication date:	04/22/1991
Pages:	448
Product dimensions:	7.00(w) x 10.00(h) x (d)

About the Author

Jacques Bourbon, Ph.D., is Research Director at the Center for Cellular Biology of the Centre National de la Recherche Scientifique (C.N.R.S.) at Ivry-sur-Seine, France., Dr. Bourbon obtained his Maîtrise (B.Sc. degree) in Physiology at the Faculty of Sciences of Paris, France, in 1969 and a Doctorat es Sciences (doctoral degree) in Natural Sciences at the University Pierre et Marie Curie, Paris, in 1980. He has worked under the direction of Professor Alfred Jost at the Comparative Physiology Laboratory, University Pierre et Marie Curie, Paris, and at the Developmental Physiology Laboratory, Collège de France, Paris., Dr. Bourbon is a member of the European Tissue Culture Association and the European Respiratory Society. He has been the recipient of research grants from the Institut National de la Santé et de la Recherche Médicale (I.N.S.E.R.M.). He has been Research Associate, Department of Pediatrics, at the University of Wisconsin at Madison and Visiting Assistant Professor, Department of Biochemistry, at the University of Texas at Dallas, for which he also received a grant from the French Ministry of Foreign Affairs., Dr. Bourbon has published 40 scientific papers, is coauthor of 3 books, and has been invited to give lectures and seminars at universities and other scientific institutions from Europe and the U.S. His current research interests are in differentiation and functional maturation of lung cells in keeping with problems linked to neonatal pulmonary immaturity.

Table of Contents

Chapter 1 Pulmonary Surfactant — An Overview, Chapter 2 The Type II Pneumocyte, Chapter 3 Nature, Function, and Biosynthesis of Surfactant Lipids, Chapter 4 Structure, Function, and Regulation of Pulmonary Surfactant Proteins, Chapter 5 The Biology of the Surfactant-Associated Proteins, Chapter 6 Comparative Aspects of Pulmonary Surfactant, Chapter 7 Secretion, Alveolar Processing, and Turnover of Pulmonary Surfactant, Chapter 8 Physiological Mechanisms for the Action of Pulmonary Surfactant, Chapter 9 Role of Surfactant in Other Organs, Chapter 10 Developmental Aspects of the Alveolar Epithelium and the Pulmonary Surfactant System, Chapter 11 Fibroblast Pneumonocyte Factor, Chapter 12 Etiology of Neonatal Respiratory Distress Syndrome and the Assessment of Lung Maturity, Chapter 13 Functional Exploration of the Lung in Neonatal Respiratory Distress Syndrome. Use of Animal Models for the Study of Respiratory Distress, Chapter 14 Exogenous Surfactant in the Management of Hyaline Membrane Disease, Index