Quantitative Human Physiology: An Introduction

by Cornell University Feher Ph.D.

Overview

Quantitative Human Physiology: An Introduction, winner of a 2018 Textbook Excellence Award (Texty), is the first text to meet the needs of the undergraduate bioengineering student who is being exposed to physiology for the first time, but requires a more analytical/quantitative approach. This book explores how component behavior produces system behavior in physiological systems. Through text explanation, figures, and equations, it provides the engineering student with a basic understanding of physiological principles with an emphasis on quantitative aspects.

• Winner of a 2018 Textbook Excellence Award (College) (Texty) from the Textbook and Academic Authors Association
• Features a quantitative approach that includes physical and chemical principles
• Provides a more integrated approach from first principles, integrating anatomy, molecular biology, biochemistry and physiology
• Includes clinical applications relevant to the biomedical engineering student (TENS, cochlear implants, blood substitutes, etc.)
• Integrates labs and problem sets to provide opportunities for practice and assessment throughout the course

NEW FOR THE SECOND EDITION

• Expansion of many sections to include relevant information
• Addition of many new figures and re-drawing of other figures to update our understanding and clarify difficult areas
• Substantial updating of the text to reflect newer research results Addition of several new appendices including statistics, nomenclature of transport carriers, and structural biology of important items such as the neuromuscular junction and calcium release unit
• Addition of new problems within the problem sets
• Addition of commentary to power point presentations
• Winner of a 2018 Textbook Excellence Award (Texty) from the Textbook and Academic Authors Association

Product Details

ISBN-13:	9780128011546
Publisher:	Elsevier Science & Technology Books
Publication date:	01/02/2017
Series:	Biomedical Engineering
Sold by:	Barnes & Noble
Format:	eBook
Pages:	1008
File size:	110 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Joseph Feher is Professor Emeritus of Physiology and Biophysics at Virginia Commonwealth University. He received his Ph.D. from Cornell University, and has research interests in the quantitative understanding of the mechanisms of calcium uptake and release by the cardiac sarcoplasmic reticulum, in the mechanisms of calcium transport across the intestine, and in muscle contraction and relaxation. Dr. Feher developed a course in Introductory Quantitative Physiology for VCU's College of Engineering, Department of Biomedical Engineering and has taught that course for over fifteen years. He also has taught muscle and cell physiology to medical and graduate students and has been Course Director for the Graduate Physiology survey course in physiology given at VCU's School of Medicine.
Dr. Joseph Feher is Professor Emeritus of Physiology and Biophysics at Virginia Commonwealth University. He received his Ph.D. from Cornell University, and has research interests in the quantitative understanding of the mechanisms of calcium uptake and release by the cardiac sarcoplasmic reticulum, in the mechanisms of calcium transport across the intestine, and in muscle contraction and relaxation. Dr. Feher developed a course in Introductory Quantitative Physiology for VCU’s College of Engineering, Department of Biomedical Engineering and has taught that course for over fifteen years. He also has taught muscle and cell physiology to medical and graduate students and has been Course Director for the Graduate Physiology survey course in physiology given at VCU’s School of Medicine.

Table of Contents

Unit 1: Physical and Chemical Foundations of Physiology1.1. The Core Principles of Physiology1.2. Physical Foundations of Physiology I: Pressure-Driven Flow1.3. Physical Foundations of Physiology II: Electrical Force, Potential, Capacitance, and CurrentProblem Set 1.1. Physical Foundations: Pressure and Electrical Forces and Flows1.4. Chemical Foundations of Physiology I: Chemical Energy and Intermolecular Forces1.5. Chemical Foundations of Physiology II: Concentration and Kinetics1.6. Diffusion1.7. Electrochemical Potential and Free EnergyProblem Set 1.2. Kinetics and DiffusionUnit 2: Membranes, Transport, and Metabolism2.1. Cell Structure2.2. DNA and Protein Synthesis2.3. Protein Structure2.4. Biological MembranesProblem Set 2.1. Surface Tension, Membrane Surface Tension, Membrane Structure, Microscopic Resolution, and Cell Fractionation2.5. Passive Transport and Facilitated Diffusion2.6. Active Transport: Pumps and Exchangers2.7. Osmosis and Osmotic PressureProblem Set 2.2. Membrane Transport2.8. Cell Signaling2.9. ATP Production I: Glycolysis2.10. ATP Production II: The TCA Cycle and Oxidative Phosphorylation2.11. ATP Production III: Fatty Acid Oxidation and Amino Acid OxidationUnit 3: Physiology of Excitable Cells3.1. The Origin of the Resting Membrane Potential3.2. The Action Potential3.3. Propagation of the Action PotentialProblem Set 3.1. Membrane Potential, Action Potential, and Nerve Conduction3.4. Skeletal Muscle Mechanics3.5. Contractile Mechanisms in Skeletal Muscle3.6. The Neuromuscular Junction and Excitation–Contraction Coupling3.7. Muscle Energetics, Fatigue, and TrainingProblem Set 3.2. Neuromuscular Transmission, Muscle Force, and Energetics3.8. Smooth MuscleUnit 4: The Nervous System4.1. Organization of the Nervous System4.2. Cells, Synapses, and Neurotransmitters4.3. Cutaneous Sensory Systems4.4. Spinal Reflexes4.5. Balance and Control of MovementProblem Set 4.1. Nerve Conduction4.6. The Chemical Senses4.7. Hearing4.8. Vision4.2 Problem Set. Sensory Transduction4.9. Autonomic Nervous SystemUnit 5: The Cardiovascular System5.1. Overview of the Cardiovascular System and the Blood5.2. Plasma and Red Blood Cells5.3. White Blood Cells and Inflammation5.4. The Heart as a PumpProblem Set 5.1. Blood5.5. The Cardiac Action Potential5.6. The Electrocardiogram5.7. The Cellular Basis of Cardiac Contractility5.8. The Cardiac Function CurveProblem Set 5.2. Cardiac Work5.9. Vascular Function: Hemodynamics5.10. The Microcirculation and Solute Exchange5.11. Regulation of Perfusion5.12. Integration of Cardiac Output and Venous Return5.13. Regulation of Arterial PressureProblem Set 5.3. Hemodynamics and MicrocirculationUnit 6: Respiratory Physiology6.1. The Mechanics of Breathing6.2. Lung Volumes and Airway Resistance6.3. Gas Exchange in the LungsProblem Set 6.1. Airway Resistance and Alveolar Gas Exchange6.4. Oxygen and Carbon Dioxide Transport6.5. Acid–Base Physiology I: The Bicarbonate Buffer System and Respiratory Compensation6.6. Control of VentilationProblem Set 6.2. Gas Transport and pH DisturbancesUnit 7: Renal Physiology7.1. Body Fluid Compartments7.2. Functional Anatomy of the Kidneys and Overview of Kidney Function7.3. Glomerular FiltrationProblem Set 7.1. Fluid Volumes, Glomerular Filtration, and Clearance7.4. Tubular Reabsorption and Secretion7.5. Mechanism of Concentration and Dilution of Urine7.6. Regulation of Fluid and Electrolyte Balance7.7. Renal Component of Acid–Base BalanceProblem Set 7.2. Fluid and Electrolyte Balance and Acid–Base BalanceUnit 8: Gastrointestinal Physiology8.1. Mouth and Esophagus8.2. The Stomach8.3. Intestinal and Colonic Chemoreception and Motility8.4. Pancreatic and Biliary Secretion8.5. Digestion and Absorption of the Macronutrients8.6. Energy Balance and Regulation of Food IntakeProblem Set 8.1. Energy BalanceUnit 9: Endocrine Physiology9.1. General Principles of Endocrinology9.2. Hypothalamus and Pituitary Gland9.3. The Thyroid Gland9.4.

What People are Saying About This

From the Publisher

This text provides the engineering student with a basic understanding of physiological principles with an emphasis on quantitative aspects. It teaches the language of physiology, both qualitative and quantitative, and highlights how component behavior affects system behavior

Editorial Reviews

".. in terms of what is out there this book provides the best mix I have seen thus far of balancing the two aspects of "quantitative" "physiology" —Professor Sean Collins at University of Massachusetts - Lowell

"It would be quite useful for engineers who want to ply their trade in the physiological sciences..... I have been looking for this kind of book for a long time. I am going to show it also to more of my mathematical colleagues. I am still evaluating it and reading it myself-but I love the approach. The author needs to be congratulated for a masterpiece of a work." —Professor Lawrence Basso, MD, Stanford University

"This book is long-overdue for combined teaching of a course that moves from cellular to systems physiology that truly integrates the quantitation with the physiology. It is an extremely easily read book that covers all aspects of physiology, from the mathematical concepts that underlie how human physiology functions to medically-related diseases and conditions, as well as current medical treatments. I plan to utilize this book for upper level undergraduate biomedical engineering students in sensory and quantitative physiology, as well as for advanced graduate students in a pharmacological and physiological PhD program in medical school, with appropriate emphasis from the book for each student group according to their needs and abilities." —Amy B. Harkins, Associate Professor, Saint Louis University

"Complements to Dr. Feher, the book is excellent and the students are benefiting." —Dr. David Reinkensmeyer, University of California, Irvine

From the Publisher