Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research / Edition 1

by Helmut Sinzinger, Bengt Samuelsson, Sir John R. Vane, Rodolfo Paoletti, Peter Ramwell

Overview

The International Symposium on Prostaglandins and Related Compounds, first held in Vienna 1972, revisited the city after 24 years for the 10TH Symposium. For the many researchers working in this multi-disciplinary field it was an opportunity to exchange their experiences and share new data with colleagues from all around the world. This scientific exchange was largely encouraged by the unseasonably cold and rainy weather. For the first time, there was quite a large attendance from the former Communist countries. Eugene Garfield prepared a key note address delivered during the meeting (The Sci­ entist 1996, 12) reviewing the contribution of the Nobel Laureates U.S. von Euler, l.R. Vane, S.K. Bergstrom, and B.I. Samuelsson, discussing the relevance of the more than 40,000 papers in this area published since 1991. Overall, there is still a rapidly growing interest, and in particular a great variety of clinical applications of this family of compounds which were discussed in detail during the meeting. Beside the lectures there were 19 workshops covering nearly all the topics of key interest. All the speakers were invited to prepare a manuscript which has resulted in the volume now in your hands. Special thanks to Dr. Patrick Wong and the new publisher of this series who helped to publish the proceedings in the usual quality and reasonable period of time. Looking forward to seeing all of you again in Florence in 1999, hopefully with much more sun.

Product Details

ISBN-13:	9780306457760
Publisher:	Springer US
Publication date:	03/31/1998
Series:	Advances in Experimental Medicine and Biology , #433
Edition description:	1997
Pages:	454
Product dimensions:	7.01(w) x 10.00(h) x 0.04(d)

About the Author

Sir John Vane is the Director General at the William Harvey Research Institute, an independent charitable foundation within Queen Mary and Westfield College of the University of London, UK.
Sir John Vane shared the Nobel Prize in Physiology or Medicine in 1982 for his discoveries of the mechanism of action of aspirin and of prostacyclin, as well as his work on other prostanoids.

Table of Contents

Some Recent Advances in Leukotriene Research; B. Samuelsson. Practical Aspects of Prostaglandin E1 before and after Solid Organ Transplantation; H. Müller et al.. Prostaglandins in Liver Transplantation; R.M. Merion. Prostaglandins in Heart Transplantation; F. Iberer et al. Eicosanoids in Peridontal Diseases: Potential for Systemic Involvement; S.M. Damaréet al. Mitogen-Activated Protein Kinases and Endothelial Prostacyclin Secretion; J.H. Grose et al. Crosstalk between Elevation of [Ca2+I, Reactive Oxygen Species Generation and Phospholipase A2 Stimulation in Human Keratinocyte Cell Line; R. Goldman et al. Cloning Tissue-Specific Expression and Regulation of the Bovine Thromboxane A2 Receptor;S. Muck, K. Schrör. Weak Inhibitors of Cyclooxygenases May Exert their Antinociceptive Effect by Modulation of Transcription Factors; N. Scheuren et al. New Group of Lipid Mediators Containing )-Hydroxyarachidonic Acid (20-HETE); K. Mao et al. Biosynthesis of Novel Divinyl Ether Oxylipins by Enzyme from Garlic (Allium Sativum L.) Bulbs; A.N. Grechkin, M. Hamberg. Catalytic and Spectroscopic Properties of Linoleate Diol Synthase of the Fungus Gaümannomyces Graminis;E.H. Oliw, C. Su. 87 Additional Articles. Index.

Editorial Reviews

One hundred papers treat advances in research of the effects and uses of prostaglandins, thromboxanes, and leukotrienes in such medical fields as organ transplantation, male erectile dysfunction, amniotic fluid infection and labour, renal function, anti-inflammatory drugs, allergic and aspirin-intolerant asthma, angioplasty and heart ischemia, Alzheimer's disease, vessel wall hyperplasia, and more. Annotation c. by Book News, Inc., Portland, Or.

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