Rna Viruses: Host Gene Responses To Infections

by Decheng Yang

Overview

This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: (i) the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; (ii) host innate and adapted immune responses to viral replication in target organs; (iii) virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and (iv) the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection.Organized into 27 highly accessible and well-illustrated chapters, this volume explores state-of-the-art knowledge of the molecular mechanisms of RNA virus infection and host-virus interactions. This comprehensive compilation of the altered gene expression profiles and signal transduction pathways in host cells in response to the majority of human/animal RNA viruses opens new directions for basic and clinical research on viral pathogenesis, and also provides valuable biomarkers for researchers to select gene targets in the development of diagnostic tests and antiviral therapeutics for a number of infectious diseases.

Product Details

ISBN-13:	9789812833792
Publisher:	World Scientific Publishing Company, Incorporated
Publication date:	01/16/2009
Pages:	724
Product dimensions:	6.10(w) x 9.10(h) x 1.50(d)

Table of Contents

Contributors ix

Preface xxiii

Section I Retrovirus 1

1 Efforts to Characterize Host Response to HIV-1 Infection Monty Montano Paola Sebastiani 3

2 Signaling Pathways Activated by HIV and Their Impact on Immune Responses Katrina Gee Sasmita Mishra Wei Ma Marko Kryworuchko Ashok Kumar 31

3 Host Immune Responses in HIV Infection Robert D. Allison Shyam Kottilil 59

4 HIV-1 and RNA Interference - Examining a Complex System Zachary A. Klase Kuan-Teh Jeang Fatah Kashanchi 83

Section II Negative Single-Stranded RNA Virus 107

5 Signaling Pathways Induced by Influenza Viruses Stephan Pleschka Stephan Ludwig Oliver Planz Thorsten Wolff 109

6 Host Immune Response to Influenza Virus Thomas M. Moran Carolina B. Lopez 131

7 Signaling Pathways in the Host Cell Response to RSV Infection Allan R. Brasier Ping Liu Bing Tian Sanjeev Choudhary 157

8 Protective and Pathologic Host Responses to Pulmonary Respiratory Syncytial Virus Infection Dennis M. Lindell Nicholas W. Lukacs 185

9 Innate Recognition of Viral Infection and the Involvement of Autophagy Balaji Ramanathan Akiko Iwasaki 209

10 VSV Infection Elicits Distinct Host Responses in the Periphery and the Brain Carol Shoshkes Reiss 229

11 Hantavirus Infection and Innate Immunity Nandini Sen Adrish Sen Peter Alff Irina Gavrilovskaya Erich R. Mackow 247

12 Measles Virus Captures Specific Host Machineries to Cause Immunosuppression and Disease Bumsuk Hahm Michael B. A. Oldstone 269

Section III Positive Single-Stranded RNA Virus 293

13 Severe Acute Respiratory Syndrome Coronavirus Induces Differential Host Gene Expression Responses Associated with Pathogenesis Vincent T. K. Chow W. F. Leong 295

14 Characterization ofSignaling Pathways in Cells Infected with SARS-CoV Tetsuya Mizutani 321

15 Impact of Filovirus Infection upon Cellular Signaling Pathways Christopher F. Basler 345

16 Responses to Ebola and Marburg Virus Infections Thomas W. Geisbert Friederike Feldmann Joan Geisbert Heinz Feldmann 371

17 Host Gene Expression Triggered by West Nile Virus Infection Janusz T. Paweska 391

18 West Nile Virus-host Interaction: An Immunological Prospective Raghavan Bhuvanakantham Mah-Lee Ng 415

19 Hepatitis C Virus (Flaviviridae): Host Immune Responses to Hepatitis C Virus Christoph Neumann-Haefelin Robert Thimme 445

20 Host responses to Hepatitis C Virus Infection: Gene Expression Profiles and Viral Pathogenesis Melanie Lambotin Francoise Stoll-Keller Thomas F. Baumert 471

21 Differential Gene Expression in Coxsackievirus Infection and Its Effect on Viral Pathogenesis Huifang M. Zhang Travis Lim Honglin Luo Bruce McManus Decheng Yang 495

22 Host Signaling Responses to Coxsackievirus Infection Guang Gao Decheng Yang Bruce M. McManus Honglin Luo 525

23 Endothelial Damage Response by Dengue Virus Infection Irene Bosch Katherine J. Martin Aniuska Becerra Artiles Rajas V. Warke 547

24 Molecular Pathogenesis of Human Norovirus Ming Tan Tibor Farkas Xi Jiang 575

25 Host Responses During Sindbis Virus Encephalomyelitis in Mice: New Implications for Understanding the Pathogenesis of Alphavirus Infections of the Central Nervous System David N. Irani Natalie A. Prow 601

Section IV Double-Stranded RNA Virus 625

26 Host Signaling Responses to Reovirus Infection Da Pan Paola Marcato Maya Shmulevitz Patrick W. Lee 627

27 Rotavirus Antagonism of the Host Innate Immune Response John T. Patton Mario Barro 655

Index 679