Table of Contents
Introduction
A Brief Conceptual Framework for Biology
PART ONE: UNDERSTANDING NATURE
1. The Antecedents of Scientific Thought
Animism, Totemism, and Shamanism
The Paleolithic View
Mesopotamia
Egypt
2. Aristotle and the Greek View of Nature
The Science of Animal Biology
The Parts of Animals
The Classification of Animals
The Aristotelian System
Basic Questions
3. Those Rational Greeks?
Theophrastus and the Science of Botany
The Roman Pliny
Hippocrates, the Father of Medicine
Erasistratus
Galen of Pergamum
The Greek Miracle
4. The Judeo-Christian Worldview
The Bishop of Hippo
Scholastic Thought
Islamic Science
Books on Beasts
Antecedents of a Revolution
5. The Revival of Science
Andreas Vesalius and the Study of Structure
William Harvey and the Study of Function
Sir Francis Bacon's Great Instauration
Induction, Hypothesis, Deduction
The Very SmallAnimalcules
Robert Hooke and the Discovery of Cells
6. Figur'd Stones and Plastick Virtue
Marine Life on Mountain Tops?
Figured Stones of Unknown Creatures
Baron Cuvier
Quarries of the Paris Basin
Catastrophism and Uniformitarianism
William Smith and the Geological Column
Understanding Nature in 1850
PART TWO: THE GROWTH OF EVOLUTIONARY THOUGHT
7. The Paradigm of Evolution
First Questions
The Paradigm of Natural Theology
First Answers
8. Testing Darwins Hypotheses
Have Life Forms Changed over Time?
Do Species Evolve into Different Species over Time?
Has There Been Time Enough for Evolution?
Is Natural Selection the Mechanism of Change?
The Genetic Basis of Natural Selection
Accounting for the Diversity of Life
9. In the Light of Evolution
Comparative Anatomy
Embryonic Development
Classification
Microstructure
Molecular Processes
10. Life over Time
The Origin of Life
The Rise of Multicelled Organisms
What Is a Phylum?
Burgess Shale Metazoans
Early Evolution of the Vertebrates
The Age of Dinosaurs
Birds, Mammals, and Flowering Plants
The Rancho La Brea Tar Pits
Human Evolution
The Role of Extinction in Evolution
PART THREE: CLASSICAL GENETICS
11. Pangenesis
What Is the Question?
Hippocrates and Aristotle
The Darwinian Answer
Assembling the Data
Formulating the Hypothesis by Induction
Galton's Rabbits
12. The Cell Theory
The Discovery of Cells: Robert Hooke
Schwann and Cells in Animals
Gametes as Cells
Omnis cellula e cellula?
The Technology of Cell Research
13. The Hypothesis of Chromosomal Continuity
The Ephemeral Nucleus
Schneider, Flemming, and Cell Division
The Chromosomes and inheritance
Gamete Formation
Fertilization
14. Mendel and the Birth of Genetics
Model for Monohybrid Crosses
Model for Dihybrid Crosses
Mendel's Laws
Initial Opposition to Mendelism
15. Genetics + Cytology: 1900-1910
Sutton's Model
The Cytological Basis of Mendel's Laws
Boveri and Abnormal Chromosome Sets
Variations in Mendelian Ratios
The Discovery of Sex Chromosomes
16. The Genetics of the Fruit Fly
Morgan's First Hypothesis
Morgan's Second Hypothesis
The Fly Room
Linkage and Crossing-Over
The Cytological Proof of Crossing-Over
Mapping the Chromosomes
The Final Proof
The Determinants of Sex
The Conceptual Foundations of Classical Genetics
17. The Structure and Function of Genes
One Gene, One Enzyme
The Substance of Inheritance
The Watson-Crick Model of DNA
Genes and the Synthesis of Proteins
The Genetic Code
PART FOUR: THE ENIGMA OF DEVELOPMENT
18. First Principles
The Peripatetic Stagirite
The Death and Rebirth of Scientific Thought
Harvey and Malpighi
A Two-Millennial Summing Up
Preformation versus Epigenesis
19. The Century of Discovery
Von Baer's Discovery of the Mammalian Ovum
Darwin's Contribution to Embryology
Haeckel and Recapitulation
20. Descriptive Embryology
Germ Layers
The External Development of the Amphibian Embryo
The Internal Development of the Amphibian Embryo
21. The Dawn of Analytical Embryology
His, Roux, and Mosaic Development
Driesch and Regulative Development
Novelty in Development
Cell Lineage
Nucleus or Cytoplasm?
Fin de Siècle
22. Interactions during Development
Amphibian Organizers
Secondary Organizers
The Reacting Tissue
The Chemical Nature of the Organizer
Putting It All Together
Conclusion
Further Reading
References
Illustration Credits
Index