Seldin and Giebisch's The Kidney: Physiology & Pathophysiology 1-2

by Robert J. Alpern (Editor), Steven C. Hebert (Editor)

Overview

A classic nephrology reference for over 20 years, Seldin&Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individual molecules work together to affect cellular and organ function, emphasizing the mechanisms of disease. With over 40 new chapters and over 1000 illustrations, this edition offers the most in-depth discussion anywhere of the physiologic and pathophysiologic processes of renal disease. Comprehensive, authoritative coverage progresses from molecular biology and cell physiology to clinical issues regarding renal function and dysfunction. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin&Giebisch’s The Kidney is your number one source for information.

* Offers the most comprehensive coverage of fluid and electrolyte regulation and dysregulation in 51 completely revised chapters unlike Brenner&Rector's The Kidney which devotes only 7 chapters to this topic.* Includes 3 sections, 31 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation. Brenner&Rector's only devotes 5 chapters to these topics.* Previous three editions edited by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology. The title for the fourth edition has been changed to reflect their considerable work on previous editions and they have also written the forward for this edition. * Over 20 million adults over age 20 have chronic kidney disease with the number of people diagnosed doubling each decade making it America's ninth leading cause of death.

Product Details

ISBN-13:	9780080559506
Publisher:	Elsevier Science
Publication date:	10/10/2007
Sold by:	Barnes & Noble
Format:	eBook
Pages:	2928
File size:	89 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Alpern has performed research in the area of epithelial physiology, focusing on the mechanisms and regulation of acid transport. He received his MD degree from the University of Chicago and then trained in Internal Medicine at Columbia Presbyterian. Following postdoctoral training in the Cardiovascular Research Institute at the University of California, San Francisco, Alpern joined the faculty at UCSF, then moved to the University of Texas Southwestern Medical School as Chief of Nephrology and later Dean of the medical school. He is now Dean of Yale School of Medicine and Ensign Professor.
Dr. Steven C. Hebert is the C.N.H. Long Professor of Physiology and Medicine at Yale University School of Medicine in New Haven, Connecticut, USA, and Chair of the Department of Cellular and Molecular Physiology. Dr Hebert’s research interests include salt and mineral metabolism, especially calcium and magnesium homeostasis, the renal handling of potassium, the diuretic-sensitive Na/K/Cl cotransporters and epithelial salt and water transport. Dr Hebert cloned and characterized the calcium-sensing receptor, the renal potassium secretory channel, ROMK, the thiazide-sensitive Na-Cl cotransporter and the loop diuretic-sensitive Na-K-2Cl cotransporter. Dr Hebert has served on the faculty of the University of Alabama, the University of Texas, Harvard Medical School-Brigham&Women’s Hospital and Vanderbilt University Medical School. Dr. Hebert was elected to the American Society for Clinical Investigation, the Association of American Physicians and the National Academy of Sciences of the USA. Amongst several awards, Dr Hebert has received the Carl W. Gottschalk Award from the American Physiological Society and the Homer W. Smith Award from the American Society of Nephrology and New York Heart Association and the A.N. Richard’s Award of the International Society of Nephrology. Dr Hebert has been editor, or on the editorial boards, of numerous physiology, membrane biology and renal-related journals. He is the author of over 260 peer-reviewed papers, reviews, book chapters and books.

Table of Contents

Epithelial and Nonepithelial Transport and RegulationGeneral Principles of Epithelial and Nonepithelial TransportTransport RegulationStructural and Functional Organization of the KidneyStructural OrganizationFunctional OrganizationRenal Differentiation and GrowthFluid and Electrolyte Regulation and DysregulationRegulation and Disorders of Sodium Chloride HomeostasisRegulation and Disorders of Water HomeostasisRegulation and Disorders of Potassium Homeostasis Regulation and Disorders of Acid-Base HomeostasisRegulation and Disorders of Magnesium HomeostasisRegulation and Disorders of Calcium HomeostasisRegulation and Disorders of Phosphate HomeostasisRegulation and Disorders of Organic Solute HomeostasisRegulation and Disorders of Proteins and MacromoleculesPathophysiology of Renal Diease Clinical Presentation of Renal DerangementsMechanisms of Renal InjuryProgression of Renal Disease Physiological Considerations in the Management of Renal DiseaseFor full table of contents please see the link on the right below the blue bar "Look inside".

Editorial Reviews

Reviewer: Sumit Narula, MD (University of Kentucky College of Medicine)
Description: "This is the fifth edition of a comprehensive review of the physiology of the kidney, including ions, channels, and transporters, pathophysiology, and clinical decisions regarding disease processes."
Purpose: The goal appears to be to provide a comprehensive review and reference on the basic and clinical science aspects of physiological and pathophysiological conditions affecting the kidney.
Audience: This will be an excellent tool for nephrologists, both clinical and research-oriented. It also provides a detailed description of processes for those requiring a more in-depth understanding.
Features: The book begins by explaining in detail the physiological processes involving the kidney and goes on to apply the concepts to the disease processes. Chapters in volume I deal primarily with the physiological aspects including ions, channels, transporters, genes, hormone effects, and pathways, while volume II focuses mainly on disease processes and their clinical management. The book gives a review of the basic physiology involving the structure and function of the kidney and it's interrelation with the hormonal pathways and with naturally occurring physiological and environmental adaptations. A book of this size could use more tables and easy-to-read figures, especially while explaining the tubular functions of the kidney and hormonal pathways.
Assessment: This is a useful resource for both clinical and research nephrologists. Though it may not make for an easy read given the complex physiological systems related to the kidneys, it does provide in-depth descriptions for those who desire them. Overall, it is a useful review and provides an interesting read if a thorough understanding of a physiological or pathophysiological process affecting the kidney is needed. I would definitely recommend this book to anyone in the nephrology community, whether clinical or research oriented.

Doody's Review Service