Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine / Edition 1

by Rui Wang

Overview

Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters.

Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.

Product Details

ISBN-13:	9781588293497
Publisher:	Springer-Verlag New York, LLC
Publication date:	06/11/2004
Edition description:	2004
Pages:	378
Product dimensions:	7.01(w) x 10.00(h) x 0.03(d)

Table of Contents

I. Gasotransmitters: Past, Present, and Future.- 1 The Evolution of Gasotransmitter Biology and Medicine: From Atmospheric Toxic Gases to Endogenous Gaseous Signaling Molecules.- 2 Interactions Between Gasotransmitters.- II. The Emergence of the First Gasotransmitter: Nitric Oxide.- 3 Nitric Oxide: Synthesis and Metabolism, Tissue Stores, and the Relationship of Endothelium-Derived Nitric Oxide to Endothelium-Dependent Hyperpolarization.- 4 Chemical Interaction of Nitric Oxide With Protein Thiols: S-Nitrosylation Signaling.- 5 Nitric Oxide and Adenosine Triphosphate-Sensitive Potassium Channels: Their Different Properties But Analogous Effects on Cellular Protection.- 6 Interactions of Nitric Oxide and Related Radical Species With KCa Channels.- 7 Nitric Oxide and Voltage-Gated Ca2+ Channels.- 8 Interactions of Nitric Oxide and Cardiac Ion Channels.- 9 S-Nitrosylation of Cyclic Nucleotide-Gated Channels.- III. Story of a Silent Killer: The Resurgence of Carbon Monoxide as the Second Gasotransmitter.- 10 Synthesis and Metabolism of Carbon Monoxide.- 11 Interaction of Carbon Monoxide With K+ Channels in Vascular Smooth Muscle Cells.- 12 Modulation of Multiple Types of Ion Channels by Carbon Monoxide in Nonvascular Tissues and Cells.- 13 The Molecular Mechanisms Underlying the Effects of Carbon Monoxide on Calcium-Activated K+ Channels.- 14 Carbon Monoxide and Signal Transduction Pathways.- 15 Carbon Monoxide-Induced Alterations in the Expression of KCa Channels in Pulmonary Artery Smooth Muscle Cells.- IV. Gas of the Rotten Egg: Hydrogen Sulfide as the Third Gasotransmitter.- 16 Hydrogen Sulfide Production and Metabolism in Mammalian Tissues.- 17 Toxicological and Environmental Impacts of Hydrogen Sulfide.- 18 Hydrogen Sulfide and the Regulation of Neuronal Activities.- 19 The Role of Hydrogen Sulfide as an Endogenous Vasorelaxant Factor.- 20 Hydrogen Sulfide and Visceral Smooth Muscle Contractility.- 21 Interaction of Hydrogen Sulfide and Adenosine Triphosphate-Sensitive Potassium Channels in Vascular Smooth Muscle Cells.- V. Gasotransmitters, Other Gaseous Molecules, and Cell Metabolism.- 22 Gasotransmitters as a Novel Class of Metabolic Regulators: Nitric Oxide, Carbon Monoxide, and Nitrous Oxide.

Editorial Reviews

Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This book offers a set of articles about the signaling properties of several gaseous molecules. Nitric oxide is well known; the others generally less familiar.
Purpose: The goal is to provide a comprehensive review of the state of research in the area of gaseous signaling molecules. Given the wide ranging activities of these modulators, this is an important contribution. The coverage is thorough and goals well met.
Audience: The target audience will include investigators, research fellows, and faculty responsible for teaching in this area. The editor is a recognized authority and has assembled a strong group of authors.
Features: The recognition of nitric oxide as a molecule with regulatory roles changed the view of many with regard to signaling pathways. This book reviews the properties of that molecule (biosynthesis, chemical properties, signaling targets) as well as two close cousins — carbon monoxide and hydrogen sulfide. It is noteworthy that the latter two species have been generally regarded as highly toxic (they are) and among the least likely candidates for normal cellular roles. Most of the actions of these "gasotransmitters" center on ion channels — sodium, potassium and calcium — and clearly have potentially major effects on their targets. An important issue relates to the mechanism of action of each, including the potential for direct chemical modification (nitrosylation, for example) of proteins. The initial chapters provide an overview of the field of gaseous signaling; these are followed by major sections devoted to each of the three. The accompanying bibliographies for each chapter are extensive and provide ample reference to original sources. Laboratories working in almost any area of signal transduction will want to have information regarding this new class of cellular second messengers — a need well served by this book.
Assessment: Although I was aware of the role of nitric oxide, I was unfamiliar with the role of the other molecules covered in this book. I found this to be an important contribution and it is worthwhile reading for most cell biologists and those studying regulation of cellular activities.

Doody's Review Service

From the foreword...

"...a paradigm-shifting assessment of the new category of transmitters, the gasotransmitters."

-Bruce McManus, MD, PhD, FRSC, Canadian Institutes of Health Research

"...well-written...the account by Sanada and colleagues is particularly interesting on cardio protection and ischeamic preconditioning...this book should be of interest to both specialist researchers as well as members of the wider scientific commuity." -BTS Newsletters

"...an excellent source of references for signal transduction mechanisms underlying he physiological functions of NO, CO, and H2S." - British Journal of Anesthesiology

From the Publisher

Reviewer: Eugene A Davidson, PhD(Georgetown University School of Medicine)
Description: This book offers a set of articles about the signaling properties of several gaseous molecules. Nitric oxide is well known; the others generally less familiar.
Purpose: The goal is to provide a comprehensive review of the state of research in the area of gaseous signaling molecules. Given the wide ranging activities of these modulators, this is an important contribution. The coverage is thorough and goals well met.
Audience: The target audience will include investigators, research fellows, and faculty responsible for teaching in this area. The editor is a recognized authority and has assembled a strong group of authors.
Features: The recognition of nitric oxide as a molecule with regulatory roles changed the view of many with regard to signaling pathways. This book reviews the properties of that molecule (biosynthesis, chemical properties, signaling targets) as well as two close cousins — carbon monoxide and hydrogen sulfide. It is noteworthy that the latter two species have been generally regarded as highly toxic (they are) and among the least likely candidates for normal cellular roles. Most of the actions of these "gasotransmitters" center on ion channels — sodium, potassium and calcium — and clearly have potentially major effects on their targets. An important issue relates to the mechanism of action of each, including the potential for direct chemical modification (nitrosylation, for example) of proteins. The initial chapters provide an overview of the field of gaseous signaling; these are followed by major sections devoted to each of the three. The accompanying bibliographies for each chapter are extensive and provide ample reference to original sources. Laboratories working in almost any area of signal transduction will want to have information regarding this new class of cellular second messengers — a need well served by this book.
Assessment: Although I was aware of the role of nitric oxide, I was unfamiliar with the role of the other molecules covered in this book. I found this to be an important contribution and it is worthwhile reading for most cell biologists and those studying regulation of cellular activities.