Signaling Pathways for Translation: Stress, Calcium, and Rapamycin

by Robert E. Rhoads (Editor)

Overview

This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. It further explores two agents that inhibit protein synthesis, calcium and the immunosuppressant rapamycin. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. Both the regulation of initiation and elongation are discussed, and the mechanisms of apoptosis are related to changes in the protein synthesis machinery.

Product Details

ISBN-13:	9783662098899
Publisher:	Springer Berlin Heidelberg
Publication date:	06/29/2013
Series:	Progress in Molecular and Subcellular Biology , #27
Sold by:	Barnes & Noble
Format:	eBook
File size:	3 MB

Table of Contents

The Regulation of eIF4F During Cell Growth and Cell Death.- Regulation of the Activity of Eukaryotic Initiation Factors in Stressed Cells.- Initiation Factor eIF2? Phosphorylation in Stress Responses and Apoptosis.- Elongation Factor-2 Phosphorylation and the Regulation of Protein Synthesis by Calcium.- Phosphorylation of Mammalian eIF4E by Mnk1 and Mnk2: Tantalizing Prospects for a Role in Translation.- Control of Translation by the Target of Rapamycin Proteins.