Skeletal Circulation In Clinical Practice

by Roy Kenneth Aaron

Overview

Bone circulation is important to our understanding of many major orthopedic conditions such as osteoarthritis, osteoporosis, repair, and tumors. Yet, circulatory physiology, basic to all healthy organs and most diseases, has been difficult to study in the skeleton. The biological regulation of blood flow is complex and the tissues have been relatively inaccessible to measurement. In recent years, however, advances have been made in understanding circulatory physiology and fluid flow in bone, functional measurement of blood flow, and the roles of circulation in bone turnover and repair. These advances have enhanced our insights into bone homeostasis and the interrelationships of circulation and skeletal biology, including repair and disease.This seminal volume presents updated information on circulatory physiology of bone and fluid flow through the bone matrix. It then describes new techniques in quantifying and imaging bone circulation. A clinical section covering circulatory elements of skeletal diseases provides valuable insight into pathophysiology that may serve as diagnostic biomarkers or therapeutic targets.

Product Details

ISBN-13:	9789814713757
Publisher:	World Scientific Publishing Company, Incorporated
Publication date:	03/09/2016
Pages:	328
Product dimensions:	6.20(w) x 9.20(h) x 0.70(d)

Table of Contents

Preface vii

Acknowledgements ix

Part 1 Physiology 1

1 The Physiology of Bone Circulation Ian McCarthy Ines Reichert 3

2 Molecular Transport, in Musculoskeletal Health and Disease Melissa L. Knothe Tate Roy K. Aaron Anita Ignatius Lutz Dürselen Stan Rockson 39

Part 2 Techniques of Measurement of Bone Circulation 51

3 The Microsphere Method for Investigating Bone Blood Flow Hermann Anetzberger Christof Birkenmaier 53

4 Laser Doppler Flowmetry Seth O'Donnell Scott Ritterman Lee Rubin 85

5 Engineering and Clinical Aspects of Photoplethysmography Roy K. Aaron Oussama Fadil Jennifer Racine Domenico Pacifici 99

6 MRI and PET Jonathan P. Dyke 117

Part 3 Pathophysiology of Skeletal Circulation 139

7 Circulatory Pathology in Osteonecrosis Lynne C. Jones Roy K. Aaron 141

8 Osteonecrosis in Patients with Sickle Cell Anemia and Other Hematologic Disorders Luke M. Vaughan Sarah A. Long Thomas Santamaría Marc J. Kahn Josephina A. Vossen Miriam A. Bredella Alan L. Schiller Henry J. Mankin 165

9 Fractures and Bone Repair Dean G. Lorich Lionel E. Lazaro 185

10 Joint Inflammation and Synovitis Alissa J. Burge 209

11 Circulatory Pathology in Osteoarthritis Roy K. Aaron 233

12 Osteoporosis, Circulation, and Fluid Dynamics Bing Zhang Jaime Mateus Alan Hargens 253

13 Circulation of the Pediatric and Adolescent Hip Jeremy Doak Jonathan Schiller Craig Eberson 283