Sleep Apnea: Implications in Cardiovascular and Cerebrovascular Disease / Edition 2

by T. Douglas Bradley, John S. Floras

Overview

Sleep Apnea: Implications in Cardiovascular and Cerebrovascular Disease specifically addresses the cardiovascular and cerebrovascular consequences of sleep apnea and is geared toward a broad readership of physicians that will ultimately aid patients suffering from sleep apnea.

The Second Edition ensures that there is a critical synthesis of existing literature and new information, linking sleep apnea to the major disease burdens faced by developed and developing nations. This synthesis includes both new basic and epidemiological data and published clinical trials linking sleep apnea to:

• inflammation
• the metabolic syndrome
• stroke
• hypertension and heart failure

Product Details

ISBN-13:	9780367384906
Publisher:	Taylor & Francis
Publication date:	09/19/2019
Edition description:	2nd ed.
Pages:	416
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

T. Douglas Bradley, John S. Floras

Table of Contents

Part I. Influence of Sleep and Respiration on the Cardiovascular System. 1. Circadian variations in clock genes: implications for cardiovascular disease. 2. Lower brainstem mechanisms of cardiorespiratory integration. 3. Mechanical interactions between the respiratory and circulatory systems. 4. Alterations in respiratory and cardiac activity during sleep onset. 5. Physiological effects of sleep on the cardiovascular system. 6. Metabolic effects of normal and disturbed sleep. 7. Oxidative stress, inflammation, and vascular function in sleep apnea. 8. Obesity, leptin and sleep apnea. Part II: Sleep Apnea and Hypertension. 9. Influence of sleep apnea on heart rate and blood pressure regulation: implications for hypertension and impaired heart rate variability. 10. Epidemiological evidence for an association between sleep apnea, hypertension and cardiovascular disease. 11. Treatment of hypertension in sleep apnea. Part III: Sleep Apnea, Ischemic Heart Disease, and Cerebrovascular Disease.12. Cardiac arrhythmias and sleep apnea. 13. Sleep apnea and atherosclerosis. 14. Sleep apnea and cerebrovascular disease. 15. Circadian variation in the incidence of cardiovascular and cerebrovascular ischemic events. Part IV: Sleep Apnea and Congestive Heart Failure. 16. Theoretical models of periodic breathing. 17. Pathophysiological interactions between sleep apnea and congestive heart failure. 18. Prevalence and prognostic significance of obstructive and central sleep apnea in heart failure. 19. Treatment of obstructive and central sleep apnea in patients with heart failure.

Editorial Reviews

3 Stars from Doody

This is a concise review of the complex interactions of sleep apnea with the cardiovascular and cerebrovascular systems. Included are excellent graphic illustrations. The editors seek to integrate current literature on the pathophysiologic consequences of sleep apnea. This book addresses the need for a comprehensive understanding of this subject. The editors meet their objectives. This book seems to be intended for practicing physicians/fellows in the fields of pulmonary and sleep medicine. The editors are credible authorities. The editors score well on physiology, including heart-lung interactions. Data from animal and human studies are nicely employed to highlight the detrimental effects of sleep apnea on blood pressure and respiration. Sleep apnea related mortality is well depicted with good explanations of mechanisms of disease. Particular emphasis is on myocardial ischemia and hypertension. Circadian variations in disease interactions between sleep apnea and stroke and proposed mechanisms of periodic breathing are explained. There is an exhaustive review of sleep apnea and CPAP in heart failure. Graphs, tables, and illustrations are appropriate and useful. Details from animal studies are excessive at times. This outstanding monograph focuses on effects of sleep apnea in cardiovascular and cerebrovascular disease with clear and logical presentations of ideas supported by studies. It will fill the void in this emerging and important field.

Shekhar A. Ghamande

Twenty chapters, presented by Bradley (cardiopulmonary sleep disorders, Toronto General Hospital of the University Health Network and Mount Sinai Hospital) and Floras (cardiology, Toronto General Hospital of the University Health Network and Mount Sinai Hospital), comprise a monograph on the way that apnea's disruption of sleep and placing of direct mechanical and neurohumoral stress on the heart and vasculature leads to pathophysiological effects. The text is divided in four parts which address, in turn, the influence of normal sleep and respiration on the cardiovascular system, the effects of sleep apnea on blood pressure, the relationship of apnea to coronary and cardiovascular disease, and the pathophysiological interactions between apnea and congestive heart failure. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Shekhar A. Ghamande, MD (Cleveland Clinic Foundation)
Description: This is a concise review of the complex interactions of sleep apnea with the cardiovascular and cerebrovascular systems. Included are excellent graphic illustrations.
Purpose: The editors seek to integrate current literature on the pathophysiologic consequences of sleep apnea. This book addresses the need for a comprehensive understanding of this subject. The editors meet their objectives.
Audience: This book seems to be intended for practicing physicians/fellows in the fields of pulmonary and sleep medicine. The editors are credible authorities.
Features: The editors score well on physiology, including heart-lung interactions. Data from animal and human studies are nicely employed to highlight the detrimental effects of sleep apnea on blood pressure and respiration. Sleep apnea related mortality is well depicted with good explanations of mechanisms of disease. Particular emphasis is on myocardial ischemia and hypertension. Circadian variations in disease interactions between sleep apnea and stroke and proposed mechanisms of periodic breathing are explained. There is an exhaustive review of sleep apnea and CPAP in heart failure. Graphs, tables, and illustrations are appropriate and useful. Details from animal studies are excessive at times.
Assessment: This outstanding monograph focuses on effects of sleep apnea in cardiovascular and cerebrovascular disease with clear and logical presentations of ideas supported by studies. It will fill the void in this emerging and important field.

Doody's Review Service