Solid-Phase Synthesis: A Practical Guide / Edition 1

by Fernando Albericio

Overview

This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.

Product Details

ISBN-13:	9780824703592
Publisher:	Taylor & Francis
Publication date:	04/28/2000
Pages:	848
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

Steven A. Kates, Fernando Albericio

Table of Contents

The solid support strategy in solid-phase synthesis; amino acids -alpha-amino protecting groups; side-chain protecting groups; solid supports for the synthesis of peptides and small molecules; coupling methods - solid-phase formation of amide and ester bonds; homodetic cyclic peptides; disulfide formation in synthetic peptides and proteins -the state of the art; solid-phase convergent approaches to the synthesis of native peptides and proteins; preparation of glyco-, phospho-, and sulfopeptides; oligonucleotide synthesis; synthesis of oligonucleotide-peptide conjugates and nucleopeptides; the chemistry of peptide nucleic acids; solid-phase synthesis of pseudopeptides and oligomeric peptide backbone mimetics; instrumentation; the purification of synthetic peptides; analysis of synthetic peptides; the chromatographic analysis of combinational arrays - parallel HPLC and HPLC-MS.

Editorial Reviews

Prepublication praise for Solid-Phase Synthesis... "Both Fernando Albericio and Steven Kates, as well as most of the authors of individual chapters, are well known to members of the synthetic peptide community and the information they provide can be considered authoritative and reliable.... "While writing this piece I had occasion to look in the manuscript for answers to two specific questions and readily found both. I intend to keep a copy of this book on my desk for ready reference and I can recommend that every peptide chemist and many classical organic chemists do the same.

R. B. Merrifield

...excellent....provides the most comprehensive, authoritative, and up-to-date coverage of solid-phase synthesis..

Journal of Medicinal Chemistry

This hands-on reference tool provides the information necessary to synthesize molecules by solid-phase synthesis (SPS)<-->employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. The volume presents new strategies for creating a wide variety of compounds useful for drug discovery in coming years. Representing the work of 36 scientists, the book also provides experimental procedures and a literature review for peptides, DNA, PNA, carbohydrates, peptidomimetics, and small molecular assembly. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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