Statistical Evaluation of Mutagenicity Test Data

by David J. Kirkland

Overview

The expertise of toxicologists and statisticians to provide a rigorous and practical account of the interpretation of mutagenicity test data has been drawn upon for this volume. Now, chemicals such as drugs, food additives and pesticides all need careful screening to eliminate potentially mutagenic compounds. Although guidelines exist on the performance of these tests, advice on data evolution is scarce. This niche is now filled by providing the statistical background necessary for toxicologists to understand, design and interpret mutagenicity tests. In addition to the nine chapters dealing with the different tests explained, there is an introductory chapter on some of the statistical principles included, a glossary of useful terms and an appendix providing vital information on the availability of computer software.

Product Details

ISBN-13:	9780521048149
Publisher:	Cambridge University Press
Publication date:	01/03/2008
Pages:	312
Product dimensions:	5.90(w) x 8.90(h) x 0.90(d)

Table of Contents

Steering group; Contributors; Preface; List of abbreviations; 1. Statistics and genetic toxicology - setting the scene D. P. Lovell; 2. Analysis of data from microbial colony assays G. A. T. Mahon, M. H. L. Green, B. Middleton, I. de G. Mitchell, W. D. Robinson and D. J. Tweats (group leader); 3. Mammalian cell gene mutation assays based upon colony formation C. F. Arlett (group leader), D. M. Smith, G. M. Clarke, M. H. L. Green, J. Cole, D. B. McGregor and J. C. Asquith; 4. Statistical evaluation of bacterial/mammalian fluctuation tests W. D. Robinson, M. H. L. Green (group leader), J. Cole, M. J. R. Healy, R. C. Garner and D. Gatehouse; 5. Analysis of data from in vitro cytogenetic assays C. Richardson (group leader), D. A. Williams, J. A. Allen, G. Amphlett, D. O. Chanter and B. Phillips; 6. Statistical methods for sister chromatid exchange experiments D. Cooke, J. Allen, M. G. Clare, C. J. Doré and L. Henderson (group leader); 7. Statistical analysis of in vivo cytogenetic assays D. P. Lovell, D. Anderson (group leader), R. Albanese, G. E. Amphlett, G. Clare, R. Ferguson, M. Richold, D. G. Papworth and J. R. K. Savage; 8. Statistical methods for the dominant lethal assay D. O. Chanter, D. Anderson, A. Bateman, D. P. Lovell, A. K. Palmer, M. T. Stevens and M. Richold (group leader); 9. Statistical methods for the design and analysis of mutation experiments with the fruit fly Drosophila melanogaster R. D. Combes (group leader), J. Bootman, M. G. Ford, J. Hepworth and D. W. Salt; Appendices; Index.

Editorial Reviews

"In summary, this is not a cook book for either statisticians or mutageniticists. This book is a bridge between the two disciplines. It will help the statisticians to understand the problems the mutageniticists encounter in their experiments and help the latter converse fluently with the former to effectively interpret the outcomes of their experiments. Both statisticians and genetic toxicologists will benefit tremendously from this book and should have it on their desks." Journal of Toxicology and Environmental Health

From the Publisher