Table of Contents
Introduction - In Search of Eternal Life vii
Chapter 1 Development of the Embryo 1
Chapter 2 A Brief Introduction to Growing Cells Outside the Body, or Cell Culture 7
Chapter 3 Regeneration and Stem Cells 11
Chapter 4 Adult Stem Cells 15
4.1 Bone Marrow 15
4.2 Self-Renewal 20
4.3 Clinical Trials with Adult Stem Cells 23
4.4 Other Sources of Adult Stem Cells 26
4.5 Cancer Stem Cells 35
4.6 Mechanisms of Action of Adult Stem Cells 36
4.7 Mesenchymal Stem Cells and Control of the Immune System 39
4.8 Adult Stem Cells: Conclusions 41
Chapter 5 Embryonic Stem Cells 43
5.1 The Embryonic Stem Cell Controversy 49
5.2 The Long Road to Human Embryonic Stem Cells in Brazil 54
5.3 Clinical Trials with Human Embryonic Stem Cells 58
5.4 Personalized Cell Therapy 61
5.5 Studying Human Biology with Pluripotent Stem Cells 69
5.6 Pluripotcnt Stem Cells for Drug Development 73
Chapter 6 Cell Therapy - Promise or Reality? 79
Chapter 7 Outlook 83
Final Note 89
References 91
Index 95