Synaptic Tagging and Capture: From Synapses to Behavior

by Sreedharan Sajikumar

Overview

Serves as a comprehensive introduction and overview of synaptic tagging and capture (STC) and covers the topic from molecular and cellular aspects to behavior. Circa 15 years ago the STC model was proposed to provide a conceptual basis for how short-term memories are transformed into long-term memories. Though the hypothesis remains unconfirmed due to technological limitations, the model is well consolidated and generally accepted in the field. Various researchers have investigated the cellular mechanisms for the formation of long-term memory using the STC model, but this is the first book-length treatments of STC. This volume features an introduction by Prof. Richard Morris and Prof. Cliff Abraham.

Product Details

ISBN-13:	9781493917600
Publisher:	Springer New York
Publication date:	10/16/2014
Edition description:	2015
Pages:	263
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

About the Author

Sajikumar Sreedharan, PhD, is Associate Professor and Research Director, Department of Physiology and Health Longevity Programme, Neurobiology Program, National University of Singapore. He is Editor of the Springer journal, Experimental Brain Research.

Ted Abel, PhD, is Director, Iowa Neuroscience Institute, and Roy J. Carver Chair in Neuroscience, University of Iowa, Iowa City, Iowa. He is Editor-in-Chief of Neurobiology of Learning and Memory and a member of the editorial board of Hippocampus.

Table of Contents

1: Synaptic tagging and capture: functional implications and molecular mechanisms.- 2: Role of calcium-permeable AMPARs in synaptic tagging and capture in the rodent hippocampus.- 3: Molecular mechanisms underlying synaptic tagging and consolidation.- 4: Metaplasticity and Synaptic Tag and Capture: Differential Dynamics of Plasticity Regulation in the Hippocampus.- 5: Activity-dependent protein transport as a synaptic tag.- 6: PKA Anchoring and Synaptic Tagging and Capture.- 7: Compartmentalization of synaptic tagging and capture.- 8: Synaptic cooperation and competition: two sides of the same coin?.- 9: Neuropsin-dependent and -independent synaptic tagging and modulation of long-term potentiation: A quest for the associated signaling pathway(s).- 10: BDNF and TrkB mediated signalling supporting processes of Metaplasticity and long- term memory formation.- 11: Prescient Synapses: Gating Future Neuronal Consciousness Through Synaptic Tagging and Metaplasticity.- 12: Exploring New Horizons: Synaptic Tagging and Capture Beyond Space and Time.- 13: From where? Synaptic Tagging Allows the Nucleus Not to Care.- 14: Unlocking the Memory Vault: Dopamine, Novelty, and Memory Consolidation in the Hippocampus.- 15: Dopamine and Synaptic Tagging and Capture: A Neuromodulatory Interplay that Shapes Associative Plasticity.- 16: Astrocytes, the rising stars that regulate synaptic plasticity and long-term memory formation.- 17: Synaptic tagging in the ACC: basic mechanisms and functional implications.- 18: Emotional tagging and long-term memory formation.- 19: The Behavioral Tagging Hypothesis and Its Implications for Long-Term Memory Formation.- 20. Behavioral Tagging in the Developing Animal.- 21: Spatial Map: Through the Lens of Behavioural Tag and Capture.- 22: Behavioural Tagging: Unveiling the Intricacies of Memory Consolidation.- 23: Modeling emergent dynamics arising from synaptic tagging and capture at the network level.