Target Organ Toxicity: Volume 2 / Edition 1

by Gerald M. Cohen

Overview

First published in 1986: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Product Details

ISBN-13:	9780367258719
Publisher:	Taylor & Francis
Publication date:	06/30/2020
Series:	Routledge Revivals
Pages:	234
Product dimensions:	8.25(w) x 11.00(h) x (d)

About the Author

Gerald M. Cohen Ph.D. is Head of the Toxicology Unit, Department of Pharmacology, The School of Pharmacy, University of London.

Table of Contents

1. The Kidney as a Target Organ for Toxicity 2. Cardiac Toxicity 3. The Lung as a Target Organ for Toxicity 4. Target Organ Toxicity: The Male Reproductive System 5. Toxic Effects on the Female Reproductive System 6. The Eye 7. The Inner Ear 8. The Endocrine Pancreas as a Target Organ for Toxicity 9. Structural DNA Modifications and DNA Repair in Organ-Specific Tumor Induction 10. Organ Specificity in Tumor Initiation and Comple Carcinogenesis (Including Species Variation)