Textbook of Organ Transplantation Set

by Allan D. Kirk (Editor), Stuart J. Knechtle (Editor), Christian P. Larsen (Editor), Joren C. Madsen (Editor), Thomas C. Pearson (Editor)

Overview

Brought to you by the world’s leading transplant clinicians, Textbook of Organ Transplantation provides a complete and comprehensive overview of modern transplantation in all its complexity, from basic science to gold-standard surgical techniques to post-operative care, and from likely outcomes to considerations for transplant program administration, bioethics and health policy.

Beautifully produced in full color throughout, and with over 600 high-quality illustrations, it successfully:

• Provides a solid overview of what transplant clinicians/surgeons do, and with topics presented in an order that a clinician will encounter them.
• Presents a holistic look at transplantation, foregrounding the interrelationships between transplant team members and non-surgical clinicians in the subspecialties relevant to pre- and post-operative patient care, such as gastroenterology, nephrology, and cardiology.
• Offers a focused look at pediatric transplantation, and identifies the ways in which it significantly differs from transplantation in adults.
• Includes coverage of essential non-clinical topics such as transplant program management and administration; research design and data collection; transplant policy and bioethical issues.

Textbook of Organ Transplantation is the market-leading and definitive transplantation reference work, and essential reading for all transplant surgeons, transplant clinicians, program administrators, basic and clinical investigators and any other members of the transplantation team responsible for the clinical management or scientific study of transplant patients.

Product Details

ISBN-13:	9781118889633
Publisher:	Wiley
Publication date:	07/21/2014
Sold by:	JOHN WILEY & SONS
Format:	eBook
Pages:	1880
File size:	81 MB
Note:	This product may take a few minutes to download.

About the Author

Allan D. Kirk is a Professor of Surgery and Pediatrics and a practicing transplant surgeon and physician at Emory University Hospital and Children's Healthcare of Atlanta. Dr. Kirk was the inaugural Chief of the NIH intramural Transplantation Branch and he has been Principal Investigator (PI) for multiple past and ongoing clinical trials. Dr. Kirk's bibliography contains over 200 peer-reviewed manuscripts and he is Editor-in-Chief of the American Journal of Transplantation.

Joren C. Madsen is the founding Director of the MGH Transplant Center, which encompasses kidney, liver, lung, heart, pancreas and small bowel transplantation and is Co-Director of the Transplantation Biology Research Center, a multi-disciplinary group of scientists translating discoveries in basic immunology into clinical protocols. Dr. Madsen has authored more than 150 publications and served on the editorial boards of Transplantation, the American Journal of Transplantation, and the Annals of Thoracic Surgery. In 2009, Dr. Madsen became the first surgeon to be elected president of the American Society of Transplantation.

Chris Larsen, MD, DPhil, became Dean of Emory University School of Medicine, Vice President for Health Center Integration for the Woodruff Health Sciences Center, and Chairman of the Board of The Emory Clinic in January 2013. An internationally recognized leader in transplant surgery and immunology, Larsen joined the Emory medical faculty in 1991 and was appointed Chair of Surgery in 2009. He became founding director of the Emory Transplant Center (ETC) in 2001, building and directing one of the foremost research and clinical transplantation programs in the world.

Table of Contents

Contents

List of Contributors

Volume 1

Section 1: History/Introduction 1

Introduction 3

Allan D. Kirk

1 A Brief History of Clinical Organ Transplantation 5

Sir Roy Y. Calne

Section 2: Transplantation Biology 13

Immunology

2 An Overview of Physiologic Immunity 15

Hēth R. Turnquist, Giorgio Raimondi, Diana Metes, and Angus W. Thomson

3 Transplant Antigens: A Brief History of HLA 30

Paul I. Terasaki

4 Transplant Antigen Biology 36

Raja Rajalingam, Qiuheng Zhang, J. Michael Cecka, and Elaine F. Reed

5 Cellular Mechanisms of Adaptive Immunity 50

Maria-Luisa Alegre

6 Humoral Mechanisms of Adaptive Immunity 60

William M. Baldwin III and Robert L. Fairchild

7 Innate Immunity 68

Melissa Y. Yeung, Sacha A. De Serres, and Xian C. li

8 Mechanisms of Immune Regulation 79

Kathryn J. Wood, Andrew Bushell, and Joanna Hester

9 The Spectrum of Alloimmunity, Heterologous Immunity, and Relevant Autoimmunity 87

Mandy L. Ford, Andrew B. Adams, and Christian P. Larsen

10 Fundamental Concepts Regarding Graft Injury and Regeneration: Tissue Injury, Tissue Quality, and Recipient Factors 99

Chatchai Kreepala, Konrad S. Famulski, and Philip F. Halloran

11 Mechanisms of Allograft Tolerance 119

Raul Badell and Allan D. Kirk

12 Xenoimmunity 134

Peter J. Cowan and Anthony J.F. d’Apice

Experimental Transplantation

13 In Vitro Models of Alloreactivity 150

Charles A. Su, Anna Valujskikh, William M. Baldwin III, and Robert L. Fairchild

xi

14 Small Animal Models of Transplantation 158

Lakshman Gunaratnam, Anthony M. Jevnikar, and Roslyn B. Mannon

15 Large Animal Models of Transplantation 185

Douglas J. Anderson, Benjamin M. Martin, Allan D. Kirk, and David H. Sachs

16 Advancing Transplantation In Silico: Studying Global Gene Expression Using Functional Genomics for Transplantation Research 208

Steven Head, Sunil M. Kurian, and Daniel R. Salomon

Mechanisms of Immune Modulation

17 Current Pathways for Immune Manipulation 219

Jason R. Lees, Agnes M. Azimzadeh, Yaozhong Ding, Jiangnan Xu, and Jonathan S. Bromberg

18 Future Pathways for Immune Manipulation 239

Allison B. Webber and Flavio Vincenti

Section 3: Organ Procurement 251

Organ Procurement and Allocation

19 Administration of Organ Procurement and Allocation 253

Jennifer M. Porter, Lori E. Brigham, and Susan Gunderson

20 Deceased Donor Management 264

John Fung, Koji Hashimoto, Bijan Eghtesad, Daniel J. Lebovitz, and Melissa Watson

Techniques for Organ Procurement

21 Techniques for Organ Procurement after Brain Death 277

Rupert Oberhuber, Timm Heinbokel, Zain Khalpey, Sayeed Malek, and Stefan G. Tullius

22 Techniques for Organ Procurement after Circulatory Death 288

Chandrasekar Santhanakrishnan and Anthony M. D’Alessandro

23 Techniques for Living Donor Kidney Procurement 293

Andrew B. Adams, Ashtar Chami, and Kenneth A. Newell

24 Techniques for Living Donor Liver Procurement 309

Koji Hashimoto, Cristiano Quintini, and Charles M. Miller

Organ Preservation and Resuscitation

25 Abdominal Organ Preservation and Resuscitation 319

Henri G.D. Leuvenink and Rutger J. Ploeg

26 Thoracic Organ Preservation and Resuscitation 334

Jonathan C. Yeung, Marcelo Cypel, John M. Craig, and Shaf Keshavjee

v

27 Kidney Paired Donation Networks 343

Adam W. Bingaman and Cathi L. Murphey

Section 4: Pre-operative Management of Transplant Patients 351

Patient Selection and Indications for

Organ Transplantation

28 Patient Selection and Indications for Kidney Transplantation 353

Jeremy Goodman and Robert S. Gaston

29 Patient Selection and Indications for Liver Transplantation 364

Kimberly A. Brown and Marwan Kazimi

30 Patient Selection and Indications for Heart Transplantation 377

Andrew L. Smith and Daniel B. Sims

31 Patient Selection and Indications for Lung Transplantation 388

Julia B. Becker and Edward R. Garrity Jr

32 Patient Selection and Indications for Pancreas and Islet Transplantation 404

Alexandra Turner and Nicole A. Turgeon

33 Patient Selection and Indications for Intestinal and Multivisceral Organ Transplantation 412

Douglas G. Farmer and Robert S. Venick

34 Role of Primary Care Provider in the Referral and Care of Abdominal Organ Transplant Patients 416

Peggy B. Hasley, Kristine S. Schonder, and Ron Shapiro

35 Role of Primary Care Provider in the Referral and Care of Thoracic Organ Transplant Patients 428

Remzi Bag, Arvind Bhimaraj, and Sireesha Garikipati

The Histocompatibility Lab

36 Alloantibodies, Sensitization and Virtual Crossmatching 443

Howard M. Gebel and Robert A. Bray

Waiting List Management

37 Waiting List Management for Kidney Transplantation 452

Phuong-Thu T. Pham, Phuong-Chi T. Pham, and Gabriel M. Danovitch

38 Waiting List Management for Liver Transplantation 462

John G. O’Grady

39 Waiting List Management for Heart Transplantation 470

Howard J. Eisen

40 Waiting List Management for Lung Transplantation 476

E. Clinton Lawrence and David C. Neujahr

41 Waiting List Management for Pancreas and Islet Transplantation 482

Jon S. Odorico

42 Waiting List Management for Intestinal and Multivisceral Transplantation 489

Kareem M. Abu-Elmagd and Guilherme Costa

Intensive Care in End Organ Failure

43 Intensive Care in Hepatic Failure 495

Jenny E. Han and Ram M. Subramanian

44 Intensive Care in Cardiac Failure 503

Josef Stehlik, Michael S. Kiernan, Deborah Budge, and Maryl R. Johnson

45 Intensive Care in Pulmonary Failure 520

John Adam Reich and Richard Eliot Fagley

Artificial Organs and Assist Devices

46 Dialysis 530

Myriam Farah and John S. Gill

47 The Artificial Liver, in vivo Tissue Engineering, and Organ Printing 545

Igor M. Sauer, Nathanael Raschzok, and Peter Neuhaus

48 Ventricular Assist Devices 554

O.H. Frazier and Steven M. Parnis

49 The Artificial Heart 563

Hannah Copeland, Jennifer Berumen, Richard G. Smith, and Jack G. Copeland

50 Artificial Lungs 568

Claire A. Watkins and Bartley P. Griffith

51 The Artificial Pancreas 576

Desmond Barry Keenan and Garry M. Steil

52 Tissue and Organ Bioengineering 584

Tracy C. Grikscheit and Erik R. Barthel

Organ Acceptance and Risk Management

Assessment

53 Organ Assessment and Acceptance for Standard and Expanded Criteria Donors 594

Matthew Cooper and Stephen T. Bartlett

54 Organ Assessment and Acceptance for Donation after Circulatory Death Donors 605

Silke Niederhaus and Anthony M. D’Alessandro

Section 5: Transplant Procedure and Surgical Technique 617

55 Kidney Transplantation Procedure and Surgical Technique 619

Paul L. Tso and Thomas C. Pearson

56 Liver Transplantation Procedure and Surgical Technique 631

Joseph F. Magliocca, Steven I. Hanish, Eugenia K. Page, and Stuart J. Knechtle

57 Living Donor Liver Transplantation Procedure and Surgical Technique 639

Sung-Gyu Lee, Deok-Bog Moon, and Jung-Man Namgoong

58 Heart Transplantation Procedure and Surgical Technique 657

John M. Craig, Soyoung Lee, Gus J. Vlahakes, and Joren C. Madsen

59 Lung Transplantation Procedure and Surgical Technique 667

R. Duane Davis and Matt Hartwig

60 Pancreas Transplantation Procedure and Surgical Technique 674

Dixon B. Kaufman, Jon Odorico, and Hans W. Sollinger

61 Islet Cell Transplantation Procedure and Surgical Technique 682

A.M. James Shapiro and Camillo Ricordi

62 Intestinal Transplantation Procedure and Surgical Technique 691

Thomas Fishbein

63 Multivisceral Transplantation Procedure and Surgical Technique 697

Lokesh Bathla and Alan Langnas

64 Vascularized Composite Allograft Transplantation Procedure and Surgical Technique 703

Gerald Brandacher, Jaimie T. Shores, Chad R. Gordon, Damon S. Cooney, and W.P. Andrew Lee

Index

Volume 2

Section 6: Post-transplant Management 715

Immunosuppressive Therapy

65 Induction Immunosuppressive Therapy 717

Ali H. Charafeddine and Allan D. Kirk

66 Maintenance Immunosuppressive Therapy 732

Karen L. Hardinger, Daniel C. Brennan, and Christina L.M. Klein

67 Rescue Immunosuppressive Therapy 754

Mark D. Stegall and Patrick G. Dean

68 Desensitization Protocols for Organ Transplantation 763

Carmen Lefaucheur and Denis Glotz

Clinical Allograft Rejection Syndromes:

Diagnosis and Management

69 Clinical Allograft Rejection Syndromes in Kidney Transplantation 773

Brian J. Nankivell

70 Clinical Allograft Rejection Syndromes in Liver Transplantation 789

Matthew H. Levine and Sandy Feng

71 Clinical Allograft Rejection Syndromes in Heart Transplantation 802

Keyur B. Shah, Joren C. Madsen, and Mandeep R. Mehra

72 Clinical Allograft Rejection Syndromes in Lung Transplantation 813

David C. Neujahr

73 Clinical Allograft Rejection Syndromes in Pancreas and Islet Transplantation 824

Parsia A. Vagefi and Peter G. Stock

74 Clinical Allograft Rejection Syndromes in Intestinal Transplantation 830

Andreas Tzakis, Gennaro Selvaggi, Akin Tekin, Jennifer Garcia, Ji Fan, and Phil Ruiz Jr

75 Clinical Allograft Rejection Syndromes in Vascularized Composite Allotransplantation 835

Stefan Schneeberger and Gerald Brandacher

76 Clinical Transplantation Tolerance 844

Tatsuo Kawai, David H. Sachs, and A. Benedict Cosimi

Clinical Recurrent Disease: Diagnosis and

Management

77 Recurrent Disease after Kidney and Pancreas Transplantation 855

Lorna K. Henderson and Philip J. O’Connell

78 Recurrent Disease after Liver Transplantation 869

Samir Parekh and James R. Spivey

79 Recurrent Disease after Heart Transplantation 883

Jignesh K. Patel and Jon A. Kobashigawa

80 Recurrent Disease after Lung Transplantation 898

Todd L. Astor

Histopathological Syndromes of Graft Rejection

and Recurrent Disease

81 Histopathological Syndromes of Kidney Allograft Rejection and Recurrent Disease 910

Alton Brad Farris, III and Michael H. Mengel

82 Histopathological Syndromes of Liver Allograft Rejection and Recurrent Disease 927

Anthony J. Demetris, Marta I. Minervini, Michael A. Nalesnik, Erin Rubin, Parmjeet Randhawa, and Eizaburo Sasatomi

83 Histopathological Syndromes of Heart Allograft Rejection and Recurrent Disease 957

E. Rene Rodriguez and Carmela D. Tan

84 Histopathological Syndromes of Lung Allograft Rejection and Recurrent Disease 981

Carol Farver and W. Dean Wallace

85 Histopathological Syndromes of Pancreas and Islet Allograft Rejection and Recurrent Disease 989

Cinthia Beskow Drachenberg and John C. Papadimitriou

86 Histopathological Syndromes of Intestinal Allograft Rejection and Recurrent Disease 1011

Phillip Ruiz, Jennifer Garcia, Akin Tekin, Seigo Nishida, and Andreas Tzakis

87 Histopathological Syndromes of Vascularized Composite Allograft Rejection and Recurrent Disease 1023

Alexandra P. Turner, Alton Brad Farris, III, Alessandrina M. Freitas, and Linda C. Cendales

Post-operative Monitoring

88 Cardiovascular Disease and Preventive Healthcare after Organ Transplantation 1030

Stephen Pastan and Divya Gupta

89 Monitoring for HLA Antibody after Organ Transplantation 1059

Robert A. Bray and Howard M. Gebel

90 Biomarkers and Alloimmune Monitoring after Organ Transplantation 1065

Oriol Bestard, Birgit Sawitzki, and Alberto Sánchez-Fueyo

91 Protective Immune Competence after Organ Transplantation 1079

Aneesh K. Mehta

Transplant Infectious Diseases

92 Donor-derived Infections after Organ Transplantation 1088

Marissa B. Wilck and Emily A. Blumberg

93 Perioperative Infections after Organ Transplantation 1105

Daniel Kaul and Michael Green

94 Late Infectious Disease after Organ Transplantation 1117

Jay A. Fishman and Robin K. Avery

Malignancy in Transplantation

95 General Malignancy after Organ Transplantation 1134

Oriol Bestard, Josep M. Cruzado, and Josep M. Grinyó

96 Post-Transplant Lymphoproliferative Disorders 1147

Michael Green and Steven A. Webber

Pregnancy and Contraception in Transplantation

97 Pregnancy and Contraception in Transplantation 1161

Serban Constantinescu, Veronica Gomez-Lobo, John M. Davison, Michael J. Moritz, and Vincent T. Armenti

The Transplant Pharmacopeia

98 Drugs Specifically Approved for Transplant Indications 1179

Winston A. Ally and Avinash Agarwal

99 Infectious Disease Prophylaxis after Organ Transplantation 1202

G. Marshall Lyon, iii

100 Metabolic and Endocrine Management of the Organ Transplant Recipient 1213

Naim Issa, Scott A. Reule, and Aleksandra Kukla

101 Off-Label Use of Immunosuppressive Agents in Solid Organ Transplantation 1233

Jill C. Krisl, Rita R. Alloway, and E. Steve Woodle

102 Drug Interactions in Organ Transplantation 1242

William D. Simmons, Pamala A. Jacobson, and Karen L. Hardinger

Section 7: Long-term Transplant Outcomes 1257

103 Long-term Outcomes after Kidney Transplantation 1259

Sundus A. Lodhi and Neema Stephens

104 Long-term Outcomes after Liver Transplantation 1267

Heidi Yeh, Paulo Martins, and James F. Markmann

105 Long-term Outcomes after Heart Transplantation 1280

Michelle M. Kittleson and Jon A. Kobashigawa

106 Long-term Outcomes after Lung and Heart-Lung Transplantation 1288

Toshihiro Okamoto, David Wheeler, and Kenneth R. McCurry

107 Long-term Outcomes after Pancreas Transplantation 1300

Philip Y. Wai and Hans W. Sollinger

108 Long-term Outcomes after Islet Transplantation 1314

A.M. James Shapiro and Camillo Ricordi

109 Long-term Outcomes after Intestinal and Multi-visceral Transplantation 1334

Jennifer Garcia, Gennaro Selvaggi, Akin Tekin, Phillip Ruiz, and Andreas Tzakis

110 Long-term Outcomes after Vascularized Composite Allograft Transplantation 1338

Alessandrina M. Freitas and Linda C. Cendales

Section 8: Pediatric Transplant 1353

111 An Introduction to Pediatric Organ Transplantation 1355

Steven A. Webber and Allan D. Kirk

112 Developmental Immunity: From Birth to Adult 1357

Simon Urschel and Lori J. West

113 Pediatric Kidney Transplantation 1370

William Harmon

114 Pediatric Liver Transplantation 1390

John C. Bucuvalas and Sandy Feng

115 Pediatric Heart Transplantation 1406

Steven A. Webber

116 Pediatric Lung Transplantation 1420

Albert Faro and Stuart C. Sweet

117 Pediatric Intestinal and Multivisceral Organ Transplantation 1430

Douglas G. Farmer

Special Pediatric Considerations

118 Growth and Development after Organ Transplantation 1435

Franz Schaefer

119 Cognitive Development and Functional Outcomes after Organ Transplantation 1443

Estella M. Alonso, Saeed Mohammad, and Lisa G. Sorensen

120 Nonadherence, Psychosocial Adaptation and Its Effects in Pediatric Transplantation 1453

Robert Ettenger and Margaret L. Stuber

121 Management of the Organ Transplant Recipient in the Transition from Pediatric to Adult Care 1475

Sandra Amaral and Lorraine E. Bell

Section 9: Transplant Administration 1489

122 Transplant Coordination 1491

Dianne LaPointe Rudow

123 Transplant Pharmacy Services 1497

Christin C. Rogers, Nicole A. Pilch, Eric M. Tichy, Lonnie D. Smith, David J. Taber, and Rita R. Alloway

124 Inpatient Transplant Unit Management 1509

Linda Ohler, Margaret Schaeffer, Kelly Carter, and Donna George

125 Transplant Clinic Management 1518

Elizabeth A. Kallenborn, Chris Shay-Downer, Kathy Schwab, and Shelley Zomak

126 Transplant Center Management and Leadership – A Case for Structured Intrapreneurship 1533

Luke Preczewski, Gwen McNatt, and Michael Abecassis

127 Transplant Quality Programs 1542

Christian Morath, Peter Schemmer, and Martin G. Zeier

128 National and International Transplant Management and Oversight 1549

Virginia A. McBride, Esther-Marie Carmichael, Linda Ohler, and Jeremy Chapman

Transplant Education

129 Abdominal Solid Organ Transplantation Fellowship Training 1562

Rachel C. Forbes and Mitchell L. Henry

130 Medical Solid Organ Transplant Fellowship Training 1566

Deirdre Sawinski and Roy D. Bloom

131 Transplantation in General Medical Education 1572

Rowena Delos Santos and Douglas J. Norman

Section 10: Clinical Trials and Data Management 1581

132 Building and Sustaining a Local Transplant Data Management Program 1583

Regina Eady, Tim Morris, Marc J. Overcash, and Jeff Weaver

133 National Transplant Data Registries and Population Studies 1598

Allan B. Massie and Dorry L. Segev

134 Clinical Research Methods and Analysis in Organ Transplantation 1607

Jesse D. Schold and S. Joseph Kim

135 Comparative Effectiveness in Transplantation 1622

Edward A. Meister and Bruce Kaplan

Section 11: Transplant Policy 1639

Transplant Ethics

136 Transplant Ethics for Clinicians 1641

Richard N. Formica Jr and Francis L. Delmonico

137 The Ethics of Organ Allocation 1645

Richard S. Luskin and Alexandra K. Glazier

138 The Ethics of Living Donation 1654

Alice Peng and Andrew Klein

139 Cultural Variations in Organ Transplantation 1662

Chris J. Callaghan and J. Andrew Bradley

Economic and Societal Impact of Transplantation

and Transplant Policy

140 Federal and Private Insurance Coverage for Organ Transplantation 1673

Timothy L. Pruett

141 Drug Development in Solid Organ Transplantation and the Approval Process for Transplant Immunosuppressants 1679

Candace Wang, J. Mark Hexham, Alan Slade, Peter Heining, Ronald G. Van Valen, Guido Junge, and Marc I. Lorber

142 Organ Specific Benefits of Transplantation: Outcomes and Economics 1690

David A. Axelrod, Mark Schnitzler, and Richard Freeman

143 National Healthcare Policy, Transplant-specific Statutes, and the Future of Organ Transplantation 1703

Keren Ladin, Rui Wang, and Douglas W. Hanto

Index

ist of Contributors

Section 1 History/Introduction

0 Introduction
Allan D. Kirk and Steven B. Webber

1 A Brief History of Clinical Organ Transplantation
Sir Roy Yorke Calne

Section 2 Transplantation Biology

Immunolgy

2 Physiology of the Immune System
Heth R. Turnquist, Giorgio Raimondi, Diana Metes and Angus W. Thomson

3 Development of HLA, cross-matching, etc.
Paul Terasaki

4 Transplant Antigen Biology
Raja Rajalingam, Qiuheng Zhang, J. Michael Cecka and Elaine F. Reed

5 Cellular Mechanisms of Adaptive Immunology
Maria-Luisa Alegre

6 Humoral Mechanisms of Adaptive Immunology
William M. Baldwin III and Robert L. Fairchild

7 Innate Immunity
Melissa Y. Yeung, Sacha A. De Serres and Xian C. Li

8 Mechanisms of Regulation
Kathryn J. Wood, Andrew Bushell and Joanna Hester

9 The Spectrum of Alloimmunity, Heterologous Immunity, and Relevant Autoimmunity
Mandy L. Ford, Andrew B. Adams and Christian P. Larsen

10 Fundamental Concepts Regarding Graft Injury and Regeneration: Tissue Injury, Tissue Quality, and Recipient Factors
Chatchai Kreepala, Konrad S. Famulski and Philip F. Halloran

11 Mechanisms of Allograft Tolerance
Allan D. Kirk and Raul Badell

12 Xenoimmunity
Peter J. Cowan and Anthony J.F. d’Apice

Experimental Transplantation

13 In Vitro Models of Alloreactivity
Robert L. Fairchild, Charles A. Su, Anna Valujskikh and William M. Baldwin III

14 Small Animal Models
Lakshman Gunaratnam, Anthony M. Jevnikar and Roslyn B. Mannon

15 Large Animal Models
Douglas J. Anderson, Benjamin M. Martin, Allan D. Kirk and David H. Sachs

16 Advancing In Silico: Studying Global Gene Expression Using Functional Genomics for Transplantation Research
Steven Head, Sunil M. Kurian and Daniel R. Salomon

Mechanisms of Immune Modulation

17 Pathways for Immune Manipulation
Jason R. Lees, Agnes M. Azimzadeh, Yaozhong Ding, Jiangnan Xu and Jonathan S. Bromberg

18 Future Pathways for Immune Manipulation
Allison Webber and Flavio Vincenti

Section 3 Organ Procurement

Procurement & Allocation

19 Organ Procurement & Allocation
Jennifer Porter, Lori E. Brigham and Susan Gunderson

20 Deceased donor management
John Fung, Koji Hashimoto, Bijan Eghtesad, Daniel J. Lebovitz and Melissa Watson

Techniques for Organ Procurement

21 Donation after Brain Death
Rupert Oberhuber, Timm Heinbokel, Zain Khalpey, Sayeed Malek and Stefan G. Tullius

22 Donation after Cardiac Death
Chandrasekar Santhanakrishnan and Anthony M. D’Alessandro

23 Living Donor: Kidney
Ken Newell

24 Living Donor: Liver
Koji Hashimoto, Cristiano Quintini and Charles M. Miller

Preservation and Resuscitation

25 Organ Preservation and Resuscitation: Abdominal Organs
Henri G.D. Leuvenink and Rutger J. Ploeg

26 Organ Preservation and Resuscitation: Thoracic Organs
Jonathan C. Yeung, Marcelo Cypel, John M. Craig and Shaf Keshavjee

27 Kidney Paired Donation Networks
Adam W. Bingaman and Cathi L. Murphey

Section 4 Pre-operative Management
Patient Selection and Indications for Organ Transplantation

28 Patient Selection and Indications for Organ Transplantation: Kidney
Jeremy Goodman and Robert S. Gaston

29 Patient Selection and Indications for Organ Transplantation: Liver
Kimberly A. Brown and Marwan Kazimi

30 Patient Selection and Indications for Organ Transplantation: Heart
Andrew L. Smith and Daniel B. Sims

31 Patient Selection and Indications for Organ Transplantation: Lung
Edward R. Garrity, Jr. and Julia B. Becker

32 Patient Selection and Indications for Organ Transplantation: Pancreas & Islet
Alexandra Turner and Nicole A. Turgeon

33 Patient Selection and Indications for Organ Transplantation: Intestinal & Multivisceral
Douglas G. Farmer and Robert S. Venick

34 Role of Primary Care Provider in Care of Abdominal Organ Transplant Patients
Peggy B. Hasley, Kristine S. Schonder and Ron Shapiro

35 Role of Primary Care Provider in Care of Thoracic Organ Transplant Patients
Remzi Bag, Arvind Bhimaraj and Sireesha Garikipati

The Histocompatibility Lab

36 Alloantibodies, Sensitization and Virtual Crossmatching
Robert Bray and Howard Gebel

Waiting List Management

37 Waiting List Management: Kidney
Phuong-Thu T. Pham, Phunong-Chi T. Pham and Gabriel M. Danovitch

38 Waiting List Management: Liver
John G. O’Grady

39 Waiting List Management: Heart
Howard J. Eisen

40 Waiting List Management: Lung
E. Clinton Lawrence and David Neujahr

41 Waiting List Management: Pancreas and Islet
Jon S. Odorico

42 Waiting List Management: Intestinal and Multi-visceral
Kareem M. Abu-Elmagd and Guilherme Costa

Intensive Care in End Organ Failure

43 Intensive Care in End Organ Failure: Liver
Ram Subramanian and Jenny Han

44 Intensive Care in End Organ Failure: Heart
Maryl R. Johnson, Josef Stehlik, Deborah Budge and Michael S. Kiernan

45 Intensive Care in End Organ Failure: Lung
John Adam Reich and R. Eliot Fagley

46 Dialysis
Myriam Farah and John S. Gill

47 Artificial Liver, In Vivo Tissue Engineering, and Organ Printing – Solutions for Organ Scarcity
Peter Neuhaus, Igor M. Sauer and Nathanael Raschzok

48 Ventricular Assist Devices
O.H. Frazier and Steven M. Parnis

49 Artificial Heart
Hannah Copeland, Jennifer Berumen, Richard G. Smith and Jack G. Copeland

50 The Development and Use of Artificial Lungs in Lung Transplantation
A. Claire Watkins and Bartley P. Griffith

51 Totally Artificial Pancreas
Desmond Barry Keenan and Garry M. Steil

52 Tissue & Organ Bioengineering
Tracy C. Grikscheit and Erik R. Barthel

Organ Acceptance and Risk Management Assessment

53 Standard and Extended Criteria Donors
Stephen T. Bartlett and Matthew Cooper

54 Donation after Cardiac Death
Silke Niederhaus and Anthony M. D’Alessandro

Section 5 Transplant Procedure & Surgical Technique

55 Kidney Transplantation Procedure & Surgical Technique
Paul L. Tso and Thomas C. Pearson

56 Liver Transplantation Procedure & Surgical Technique
Joseph F. Magliocca, Steven I. Hanish, Eugenia K. Page and Stuart J. Knechtle

57 Living Donor Liver Transplantation Procedure & Surgical Technique
Sung-Gyu Lee, Deok-Bog Moon and Chung-Man Namgoong

58 Heart Transplantation Procedure & Surgical Technique
John M. Craig, Soyoung Lee, Gus J. Vlahakes and Joren C. Madsen

59 Lung Transplantation Procedure & Surgical Technique
R. Duane Davis

60 Pancreas Transplantation Procedure & Surgical Technique
Jon S. Odorico, Hans Sollinger and Dixon Kaufman

61 Islet Cell Transplantation Procedure & Surgical Technique
A.M. James Shapiro and Camillo Ricordi

62 Intestinal Transplantation Procedure & Surgical Technique
Thomas Fishbein

63 Multi-visceral Transplantation
Alan Langnas and Lokesh Bathla

64 Vascularized Composite Allograft (VCA) Transplantation Procedure & Surgical Technique
Gerald Brandacher, Jaimie T. Shores, Chad R. Gordon, Damon S. Cooney and W.P. Andrew Lee

Section 6 Post-transplant Management

Immunosuppressive Therapy

65 Induction Therapy
Ali H. Charafeddine and Allan D. Kirk

66 Maintenance Therapy
Karen L. Hardinger, Daniel C. Brennan and Christina L.M. Klein

67 Rescue Therapy: Approaches to the Treatment of Acute and Chronic Allograft Injury
Mark D. Stegall and Patrick G. Dean

68 Desensitization Protocols
Carmen Lefaucheur and Denis Glotz

Clinical Allograft Rejection Syndromes: Diagnosis & Management

69 Clinical Allograft Rejection Syndromes: Kidney
Brian J. Nankivell

70 Clinical Allograft Rejection Syndromes: Liver
Sandy Feng and Matthew H. Levine

71 Clinical Allograft Rejection Syndromes: Heart
Keyur B. Shah, Joren C. Madsen and Mandeep R. Mehra

72 Clinical Allograft Rejection Syndromes: Lung
David C. Neujahr

73 Clinical Allograft Rejection Syndromes: Pancreas and Islet
Parsia A. Vagefi and Peter G. Stock

74 Clinical Allograft Rejection Syndromes: Intestinal
Gennaro Selvaggi, Andreas Tzakis, Akin Tekin, Jennifer Garcia, Ji Fan and Philip Ruiz, Jr.

75 Clinical Allograft Rejection Syndromes: VCA
Stefan Schneeberger and Gerald Brandacher

76 Clinical Transplantation Tolerance
Tatsuo Kawai, David H. Sachs and A. Benedict Cosimi

Clinical Recurrent Disease: Diagnosis and Management

77 Post-transplant Recurrent Disease: Kidney and Pancreas
Philip J. O’Connell and Lorna K. Henderson

78 Post-transplant Recurrent Disease: Liver
Samir Parekh and James R. Spivey

79 Post-transplant Recurrent Disease: Heart
Jignesh K. Patel and Jon A. Kobashigawa

80 Post-transplant Recurrent Disease: Lung
Todd L. Astor

Histopathological Syndromes of Graft Rejection and Recurrent Disease

81 Histopathological Syndromes of Graft Rejection and Recurrent Disease: Kidney
Alton B. Farris and Michael H. Mengel

82 Histopathological Syndromes of Graft Rejection and Recurrent Disease: Liver
Anthony J. Demetris, Marta I. Minervini, Michael A. Nalesnik, Erin Rubin, Parmjeet Randhawa and Eizaburo Sasatomi

83 Histopathological Syndromes of Graft Rejection and Recurrent Disease: Heart
E. Rene Rodriguez and Carmela D. Tan

84 Histopathological Syndromes of Graft Rejection and Recurrent Disease: Lung
Carol Farver and W. Dean Wallace

85 Histopathological Syndromes of Graft Rejection and Recurrent Disease: Pancreas and Islet
Cinthia B. Drachenberg and John C. Papadimitriou

86 Histopathological Syndromes of Graft Rejection and Recurrent Disease: Intestinal
Phillip Ruiz Jr., Jennifer Garcia, Akin Tekin, Seigo Nishida and Andreas Tzakis

87 Histopathological Syndromes of Graft Rejection and Recurrent Disease: VCA
Alexandra P. Turner, Alton B. Farris, III, Alessandrina M. Freitas and Linda C. Cendales

Post-operative Monitoring

88 Cardiovascular Disease and Preventive Healthcare
Steve Pastan and Divya Gupta

89 Post-Transplant Monitoring for HLA Antibody
Robert A. Bray and Howard M. Gebel

90 Biomarkers and Alloimmune Monitoring
Oriol Bestard, Birgit Sawitzki and Alberto Sánchez-Fueyo

91 Protective Immune Competence
Aneesh Mehta

Transplant Infectious Diseases

92 Donor-derived Infections
Marissa B. Wilck and Emily A. Blumberg

93 Peri-operative Infectious Disease
Daniel Kaul and Michael Green

94 Post-Transplant Infections
Jay A. Fishman and Robin K. Avery

Malignancy in Transplantation

95 General Malignancy
Oriol Bestard, Josep M. Cruzado and Josep M. Grinyó

96 Post-Transplant Lymphoproliferative Disorders
Steven B. Webber and Michael Green

Pregnancy and Contraception in Transplantation

97 Pregnancy and Contraception in Transplantation
Serban Constantinescu, Veronica Gomez-Lobo, John M. Davison, Michael J. Moritz, and Vincent T. Armenti

The Transplant Pharmacopeia

98 Drugs Specifically Approved for Transplant Indications
Winston A. Ally and Avinash Agarwal

99 Infectious Disease Prophylaxis
G. Marshall Lyon III

100 Metabolic and Endocrine Management
Naim Issa, Scott A. Reule and Aleksandra Kukla

101 Off-Label Use of Immunosuppressive Agents in Solid Organ Transplantation
Jill C. Krisl, Rita R. Alloway, and E. Steve Woodle

102 Drug Interactions
William D. Simmons, Pamala A. Jacobson and Karen L. Hardinger

Section 7 Long-term Transplant Outcomes

103 Long-term Outcomes of Renal Transplant Recipients
Sundus A. Lodhi and Neema Stephens

104 Factors Influencing Long-Term Survival after Liver Transplantation
Heidi Yeh, Paulo Martins and James F. Markmann

105 Long-term Transplant Outcomes: Heart Transplantation
Michelle M. Kittleson and Jon A. Kobashigawa

106 Long-term Transplant Outcomes: Lung and Heart-Lung Transplantation
Toshihiro Okamoto, David Wheeler, and Kenneth R. McCurry

107 Long-term Transplant Outcomes: Pancreas Transplantation
Philip Y. Wai and Hans W. Sollinger

108 Long-term Transplant Outcomes: Islet Transplantation
A.M. James Shapiro and Camillo Ricordi

109 Long-term Transplant Outcomes: Intestinal and Multi-visceral Transplantation
Jennifer Garcia, Gennaro Selvaggi, Akin Tekin, Philip Ruiz Jr. and Andreas Tzakis

110 Long-term Transplant Outcomes: Vascularized Composite Allograft (VCA) Transplantation
Alessandrina M. Freitas and Linda C. Cendales

Section 8 Pediatric Transplant

111 An Introduction to Pediatric Organ Transplantation
Allan D. Kirk and Steven B. Webber

112 Develomental Immunology: From Birth to Adult
Simon Urschel and Lori J. West

113 Pediatric Transplant: Kidney
Bill Harmon

114 Pediatric Transplant: Liver
John C. Bucuvalas and Sandy Feng

115 Pediatric Transplant: Heart
Steven B. Webber

116 Pediatric Transplant: Lung
Stuart C. Sweet and Albert Faro

117 Pediatric Transplant: Intestinal and Multivisceral Transplant
Douglas G. Farmer

Special Pediatric Considerations

118 Growth and Development After Organ Transplantation
Franz Schaefer

119 Cognitive Development and Functional Outcomes
Estella M. Alonso, Saeed Mohammad and Lisa G. Sorensen

120 Nonadherence, Psychosocial Adaptation and Its Effects in Pediatric Transplantation
Robert Ettenger and Margaret L. Stuber

121 Management of the Recipient in the Transition from Pediatric to Adult Care
Sandi Amaral and Lorraine E. Bell

Section 9 Transplant Administration

122 Transplant Coordination
Dianne LaPointe Rudow

123 The Transplant Pharmacy
Christin C. Rogers, Nicole A. Pilch, Eric M. Tichy, Lonnie D. Smith, David J. Taber and Rita R. Alloway

124 Inpatient Transplant Unit Management
Linda Ohler, Margaret J. Schaeffer, Kelly Carter and Donna B. George

125 Transplant Clinic Management
Elizabeth A. Kallenborn, Chris Shay-Downer, Kathy Schwab and Shelley Zomak

126 Transplant Center Management and Leadership – A Case for Structured Intrapreneurship
Luke Preczewski, Gwen McNatt and Michael Abecassis

127 Transplant Quality Programs
Christian Morath, Peter Schemmer and Martin G. Zeier

128 National and International Transplant Management and Oversight
Jeremy Chapman, Virginia A. McBride, Esther-Marie Carmichael and Linda Ohler

Transplant Education

129 Abdominal Solid Organ Transplantation Fellowship Training
Rachel C. Forbes and Mitchell L. Henry

130 Medical Solid Organ Transplant Fellowship
Deirdre Sawinski and Roy D. Bloom

131 Transplantation in General Medical Education
Douglas J. Norman and Rowena de los Santos

Section 10 Clinical Trials & Data Management

132 Building and Sustaining a Local Data Management Program
Regina Eady, Tim Morris, Marc J. Overcash and Jeff Weaver

133 National Transplant Data Registries and Population Studies
Allan Massie and Dorry L. Segev

134 Clinical Research Methods and Analysis in Organ Transplantation
Jesse D. Schold and S. Joseph Kim

135 Comparative Effectiveness in Transplant
Edward A. Meister and Bruce Kaplan

Section 11 Transplant Policy

Transplant Ethics

136 Transplant Ethics for Clinicians
Richard N. Formica Jr. and Francis L. Delmonico

137 Organ Allocation
Richard S. Luskin and Alexandra K. Glazier

138 Living Donation
Alice Peng and Andrew Klein

139 Cultural Variations
Chris J. Callaghan and J. Andrew Bradley

Economic and Societal Impact of Transplantation and Transplant Policy

140 Federal and Private Insurance Coverage for Transplant Policy
Timothy L. Pruett

141 Drug Development in Solid Organ Transplantation and the Approval Process for Transplant Immunosuppressants
Candace Wang, J. Mark Hexham, Alan Slade, Peter Heining, Ronald Van Valen, Guido Junge and Marc I. Lorber

Index