The Annotated Hodgkin and Huxley: A Reader's Guide

by Indira M. Raman, David L. Ferster

Overview

The first annotated edition of the scientific papers that created the foundation of modern neuroscience and physiology

The origin of everything known about how neurons and muscles generate electrical signals can be traced back to five revolutionary papers, published in the Journal of Physiology in 1952 by Alan Hodgkin and Andrew Huxley. The principles they revealed remain cornerstones of the discipline, summarized in every introductory neuroscience and physiology course. Since that era, however, scientific practice, technology, and presentation have changed extensively. It is difficult for the modern reader to appreciate Hodgkin and Huxley’s rigorous scientific thought, elegant experimental design, ingenious analysis, and beautiful writing.

This book provides the first annotated edition of these papers, offering essential background on everything, from terminology, equations, and electronics, to the greater historical and scientific context surrounding the work. The original journal pages are displayed opposite detailed notes explaining content, process, and background, with copies of the figures replotted according to modern conventions. Indispensable for scientists, teachers, and trainees alike, The Annotated Hodgkin and Huxley makes an essential body of knowledge—and an unparalleled approach to research—accessible to a new generation of readers.

• Reproduces the original articles paired with extensive annotations on facing pages
• Replots figures with modern conventions of data display
• Explains the development of the voltage clamp and the discovery of ionic currents and action potential generation, foundational to the study of neuroscience and physiology
• Summarizes the history of electrophysiology leading to Hodgkin and Huxley’s work
• Includes appendices on relevant concepts from mathematics, physics, electronics, chemical kinetics, and numerical methods

Product Details

ISBN-13:	9780691220635
Publisher:	Princeton University Press
Publication date:	01/11/2022
Pages:	328
Product dimensions:	8.00(w) x 10.00(h) x (d)

About the Author

Indira M. Raman and David L. Ferster are professors in the Department of Neurobiology at Northwestern University. They are both fellows of the American Academy of Arts and Sciences.

Table of Contents

Introduction ix

How to Use This Book xiii

Historical Background 1

Paper 1 17

Paper 2 67

Paper 3 115

Paper 4 163

Paper 5 183

Epilogue 275

Appendix 1 Mathematical Principles 279

Appendix 2 Electrical Principles and Circuit Elements 285

Appendix 3 Electronic Circuits 293

Appendix 4 Derivations of Rates for the H&H Equations 297

Appendix 5 Numerical Methods for the H&H Equations 301

References 305

Index 307

What People are Saying About This

From the Publisher

"This wonderful and welcome book on five must-know landmark papers will appeal to anyone interested in biophysics, physiology, neuroscience, biology, applied math, or medicine. With this guide, Raman and Ferster have done a great service to the scientific community."—Bertil Hille, University of Washington

"Raman and Ferster have succeeded brilliantly with this book, which puts Hodgkin and Huxley’s famous work in historical context, explains it in modern terms, and shows how it pointed the way to the modern picture of how nerve signaling works. The annotations bring the beauty of the original experiments into sharp focus and will be a boon to students as well as their teachers."—Denis Baylor, Stanford University

Editorial Reviews

"I had never read the Hodgkin–Huxley papers until this book came my way. I am grateful that it did."—-Brian Hayes, American Scientist

"

With this guide, Raman and Ferster have not only provided lecturers with the opportunity to include a review of the original Hodgkin–Huxley papers in their courses as a rare learning experience, but also have made accessible these historical documents to any interested neuroscientist of the post-Hodgkin–Huxley generations who otherwise would probably never haven taken—and enjoyed!—the intellectual ride of reading them. For this great service, the authors deserve our applause.

"—-Günther K. H. Zupanc, Journal of Comparative Psychology A

From the Publisher