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Overview

The Human Hypothalamus in Health and Disease

Product Details

ISBN-13: 9780080862187
Publisher: Elsevier Science
Publication date: 11/02/1992
Series: ISSN , #93
Sold by: Barnes & Noble
Format: eBook
Pages: 478
File size: 16 MB
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About the Author

Dick Swaab (1944) earned his medical and doctoral degrees at the University of Amsterdam, where he became involved in brain research during his third year of medical school. He was Director of the Netherlands Institute for Brain Research from 1978 to 2005. Since 1979 he is Professor of Neurobiology at the Medical Faculty, University of Amsterdam.

In 1985, Dr. Swaab founded the Netherlands Brain Bank (NBB) to serve as a source of clinically and neuropathologically well-documented research tissue. Since its founding, the Brain Bank has provided samples from more than 4,000 autopsies to 500 research groups in 25 countries. He was director of the NBB until 2005.

He is Leader Research team Neuropsychiatric Disorders, Neth. Inst for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences (KNAW). Swaab is also appointed for 2011-2017 Chao Kuang Piu Chair of Zhejiang University, Hangzhou, P.R. China.

His major research interests focus on, sexual differentiation of the human brain in relation to gender identity and sexual orientation, aging of the brain, Alzheimer’s disease, the neurobiological basis of depression, suicide and eating disorders. He has published over 540 papers in SCI journals, authored more than 200 chapters in books, and edited more than 60 books. Swaab mentored 84 PhD students from which 16 are now full professor. He is “Companion in the Order of the Dutch Lion”, bestowed by her Royal Majesty Queen Beatrix of the Netherlands. In 2008 Swaab obtained the Academy medal for his role in national and international neuroscience.

Dick Swaab is author of the 2 volume monograph The Human Hypothalamus that appeared in the Handbook of Clinical Neurology series, Elsevier, Amsterdam (1000 pp) and the Dutch best seller We are our Brains (450.000 copies sold), that is translated in 14 languages. A children's version of the book (You are your brains) has also appeared in Dutch in 2013 and Russian (2014). Swaab's H-factor is 76.


Michel A. Hofman is at Netherlands Institute for Neuroscience, Netherlands

Table of Contents

Recent volumes in Progress in Brain Research

List of Contributors

Preface

Acknowledgements

Section I - Structure of the Human Hypothalamus

Chapter 1: Anatomy of the human hypothalamus (chiasmatic and tuberal region)

Section II - Clinical Manifestations of Hypothalamic Diseases

Chapter 2: Endocrine functions of the hypothalamus and alterations in neuroendocrine function – focus on thyrotropin and growth hormone

Chapter 3: Neurologic manifestations of hypothalamic disease

Section III - Technical Potentialities and Pitfalls in the Use of Human Material

Chapter 4: In situ hybridization histochemistry in the human hypothalamus

Chapter 5: Receptor localization in the human hypothalamus

Chapter 6: Human hypothalamic and pituitary neuroendocrine function during in vitro perifusion

Chapter 7: Brain banking and the human hypothalamus – factors to match for, pitfalls and potentials

Section IV - Biological Rhythms

The fourth C.U. Ariëns Kappers lecture

Chapter 8: The organization of the human circadian timing system

Chapter 9: Pre-natal development of a hypothalamic biological clock

Chapter 10: The human hypothalamus: comparative morphometry and photoperiodic influences

Chapter 11: Circadian rhythms and the suprachiasmatic nucleus in perinatal development, aging and Alzheimer’s disease

Section V - Development, Aging and Dementia

Chapter 12: Ontogeny of peptides in human hypothalamus in relation to sudden infant death syndrome (SIDS)

Chapter 13: LHRH neurons: functions and development

Chapter 14: The human hypothalamus in relation to gender and sexual orientation

Chapter 15: Hormonal influences on morphology and neuropeptide gene expression in the infundibular nucleus of postmenopausal women

Chapter 16: The human hypothalamo-neurohypophyseal system in relation to development, aging and Alzheimer's disease

Chapter 17: The hypothalamic lateral tuberal nucleus: normal anatomy and changes in neurological diseases

Chapter 18: Galanin tuberomammillary neurons in the hypothalamus in Alzheimer's and Parkinson's diseases

Section VI – Osmoregulation

Chapter 19: Animal models for osmoregulatory disturbances

Chapter 20: Autoimmune hypothalamic diabetes insipidus (autoimmune hypothalamitis)

Chapter 21: The molecular biology of human hereditary central diabetes insipidus

Chapter 22: The use of linkage analysis and the Centre d'Etude Polymorphisme Humain (CEPH) panel of DNA in the study of the arginine vasopressin, oxytocin and prodynorphin gene loci

Section VII - Hypothalamus and Reproduction

Chapter 23: Animal models for brain and pituitary gonadal disturbances

Chapter 24: Genetic, hypothalamic and endocrine features of clinical and experimental obesity

Chapter 25: Hypothalamic involvement in sexuality and hostility: comparative psychological aspects

Section VIII - Hypothalamus and Stress

Chapter 26: Re-examination of the glucocorticoid hypothesis of stress and aging

Chapter 27: The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia

Chapter 28: Endogenous pyrogens in the CNS: role in the febrile response

Section IX - Psychiatric Diseases

Chapter 29: Endorphins and schizophrenia

Chapter 30: Neurohypophyseal peptides and psychopathology

Subject Index

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