The Ionotropic Glutamate Receptors / Edition 1

by Daniel Monaghan, Robert Wenthold

Overview

The Ionotropic Glutamate Receptors provides the first detailed survey of the biochemical, physiological, and pharmacological properties of recombinant ionotropic glutamate receptors. The distinguished contributors show how the molecular characteristics of these receptors account for many of the properties of native ionotropic glutamate receptors. They also examine in detail the properties of glutamate receptor subunits, including receptor modulation by phosphorylation and the anatomical localization of specific glutamate receptor subunits as determined by in situ hybridization and immunochemistry. The Ionotropic Glutamate Receptors conveys the first clear insights into the molecular bases underlying the wealth of pharmacological and physiological data on these receptors.

Product Details

ISBN-13:	9781461284420
Publisher:	Springer-Verlag New York, LLC
Publication date:	09/17/2011
Series:	The Receptors
Edition description:	Softcover reprint of the original 1st ed. 1997
Pages:	379
Product dimensions:	5.98(w) x 9.02(h) x 0.03(d)

About the Author

Monaghan, Daniel T. (Univ of Nebraska); Wenthold, Robert J. (National Institute on Deafness & Other Communications Disorders)

The contributors represent the specialties of pharmacology, molecular biology, neuroscience, cell biology, and anatomy. Most are from universities in the U.S., the U.K., Germany, and Japan. Institutions prominently represented include Univ of Nebraska, Univ of Pennsylvania, Albert Einstein Coll of Med, Washington Univ, and Johns Hopkins.

Table of Contents

1 • Subtypes of Glutamate Receptors: Historical Perspectives on Their Pharmacological Differentiation.- 2 • The Topology of Glutamate Receptors: Sorting Through the Domains.- 3 • Ionotropic Glutamate Receptors: Heterogeneity by Posttranscriptional Modifications.- 4 • The Role of Alternative Splicing of the NMDAR1 Receptor Subunit in Synaptic Plasticity.- 5 • Phosphorylation of Non-NMDA Glutamate Receptor Ion Channels: Implications for Synaptic Plasticity and Their Membrane Topology.- 6 • Regulation of NMD A Receptors by Protein Phosphorylation.- 7 • A Map of Non-NMDA Receptor Subunit Expression in the Vertebrate Brain Derived from In Situ Hybridization Hishemistry.- 8 • Developmental Dynamics of Gene Expression for NMDA Receptor Channel.- 9 • Immunocyhemical Localization of Ionotropic Glutamate Receptors (GluRs) in Neural Circuits.- 10 • Functional Properties of Kainate Receptors.- 11 • The Functional Diversity of Native and Recombinant AMPA Receptors.- 12 • Electrophysiologic Characteristics of Heteromeric Recombinant NMDA Receptors: Comparison with Native Receptors.- 13 • Pharmacology of Recombinant NMDA Receptors: Possible Mechanisms for NMDA Receptor Heterogeneity.- 14 • On the Molecular Basis of NMDA Receptor Diversity.

Editorial Reviews

3 Stars from Doody

The molecular properties of glutamate receptors are covered by presenting the biochemical, physiological, and pharmacological characteristics of recombinant and native ionotropic glutamate receptors. The book provides an overview of the most recent information on the properties of glutamate receptors, a rapidly expanding field of knowledge. It also provides a good tie-in with developmental and historical basis for current directions. Advanced students and investigators are the intended audience. An impressive collection of authors contribute to this book. The book's ambitious coverage leads to slight underillustration, but this is not a big problem. In the rapidly expanding area of glutamate receptor biology-pharmacology, an overview edition is most welcome. For an introduction to the area, an update and quick reference, this book is indispensable. This is a standard reference for library, lab, and office.

Arthur V. Prancan

Reviewer: Arthur V. Prancan, PhD (Rush Medical College of Rush University)
Description: The molecular properties of glutamate receptors are covered by presenting the biochemical, physiological, and pharmacological characteristics of recombinant and native ionotropic glutamate receptors.
Purpose: The book provides an overview of the most recent information on the properties of glutamate receptors, a rapidly expanding field of knowledge. It also provides a good tie-in with developmental and historical basis for current directions.
Audience: Advanced students and investigators are the intended audience. An impressive collection of authors contribute to this book.
Features: The book's ambitious coverage leads to slight underillustration, but this is not a big problem.
Assessment: In the rapidly expanding area of glutamate receptor biology-pharmacology, an overview edition is most welcome. For an introduction to the area, an update and quick reference, this book is indispensable. This is a standard reference for library, lab, and office.

Doody's Review Service

...will be an important reference...Each chapter is worth reading in its entirety, and each provides a solid groundingin the state of research to this point...will help [to] guide us over the next six years. - Journal of Molecular Neuroscience

From the Publisher