The JNK Signaling Pathway

by Anning Lin

Overview

Signal transduction is one of the most exciting research areas in modern biology as it deals with how information flows from the extracellular environment into a living cell to change its metabolism, genotype and phenotype. With the completion of the genomes of human and several other species, it becomes even more important to elucidate the molecular mechanisms that govern cellular functions. The intracellular signaling network, which is composed of many signaling pathways, regulates most, if not all, fundamental cellular activities, from proliferation to programmed cell death (apoptosis). Over the past decade, many signaling pathways have been “mapped’ out. Nowadays, we know in great detail about how a specific signal is transmitted via specific signaling pathways, from the membrane to the nucleus, to change the functions of a cell. In this book, a group of experts present a comprehensive review of one of such signaling pathways, the JNK signaling pathway.

Product Details

ISBN-13:	9781587061202
Publisher:	Taylor & Francis
Publication date:	02/15/2006
Series:	Molecular Biology Intelligence Unit
Pages:	108
Product dimensions:	6.10(w) x 9.30(h) x 0.50(d)

About the Author

Anning Lin Ph.D. is an Associate Professor at Ben M ay Institute for Cancer Research and the Program Leader of the Cell Signaling and Gene Regulation Program of Cancer Research Center, University of Chicago, U.S.A. His main research interests include the function of the intracellular signaling network in programmed cell death and tumorigenesis, using the c-Jun N-terminal protein kinase (JNK) and IkB kinase (IKK) signaling pathways as molecular probes.

Table of Contents

Preface 1. The Discovery of JNK and Its Biological Functions 2. Regulation of JNK by Small GTPases 3. Physiological Roles of the Different JNKs: Lessons from the JNK Knockouts 4. The Biological Function of JNKKs (MKK4/MKK7 Knockout Mice) 5. The JNK Signal Transduction Pathway in Drosophila 6. Regulation of Apoptosis by the JNK Signaling Pathway 7. Oxidative Stress, JNK Activation and Cell Death 8. JNK as a Therapeutic Target