The Kinetochore:: From Molecular Discoveries to Cancer Therapy / Edition 1

by Peter De Wulf, William Earnshaw

Overview

Kinehores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinehores were first depicted over 100 years ago, but kinehore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. “The Kinehore: from Molecular Discoveries to Cancer Therapy” presents a thorough up-to-date analysis of kinehore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and “model” eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinehores is also discussed as kinehores are being mined as a very rich target for the next generations of anti-cancer drugs.

Product Details

ISBN-13:	9780387690735
Publisher:	Springer New York
Publication date:	11/11/2008
Pages:	516
Product dimensions:	6.40(w) x 9.30(h) x 1.10(d)

Table of Contents

Centromeres and Kinehores: An Historical Perspective.- The Basics of Chromosome Segregation.- The Centromere.- Neocentromeres.- Human Artificial Centromeres: Assembly of Functional Centromeres on Human Artificial Chromosomes.- Kinehore Composition, Formation, and Organization.- Evolution of Centromeres and Kinehores: A Two-Part Fugue.- Mitotic Spindle Assembly Mechanisms.- Kinehore-Microtubule Interactions.- Post-Translational Modifications that Regulate Kinehore Activity.- The Role of the Kinehore in Spindle Checkpoint Signaling.- Kinehore Regulation of Anaphase and Cytokinesis.- Roles of Centromeres and Kinehores in Meiosis.- The Kinehore-Cancer Connection.- The Kinehore as Target for Cancer Drug Development.