The Microbial Models of Molecular Biology: From Genes to Genomes

by Rowland H. Davis

Overview

This book explains the role of simple biological model systems in the growth of molecular biology. Essentially the whole history of molecular biology is presented here, tracing the work in bacteriophages in E. coli, the role of other prokaryotic systems, and also the protozoan and algal models - Paramecium and Chlamydomonas, primarily - and the move into eukaryotes with the fungal systems - Neurospora, Aspergillus and yeast. Each model was selected for its appropriateness for asking a given class of questions, and each spawned its own community of investigators. Some individuals made the transition to a new model over time, and remnant communities of investigators continue to pursue questions in all these models, as the cutting edge of molecular biological research flowed onward from model to model, and onward into higher organisms and, ultimately, mouse and man.

Product Details

ISBN-13:	9780190288556
Publisher:	Oxford University Press
Publication date:	09/11/2003
Sold by:	Barnes & Noble
Format:	eBook
File size:	7 MB

About the Author

University of California, Irvine

Table of Contents

1.	Model Systems, Model Organisms	3
2.	Morgan's Progeny	15
3.	Neurospora	27
4.	Aspergillus	47
5.	Yeast	61
6.	Leaving the Fungi	73
7.	Escherichia coli	80
8.	The T Bacteriophages	99
9.	Temperate Phages and Transduction	112
10.	DNA	123
11.	Prokaryotes Take Center Stage	130
12.	Prokaryotes: Later Contributions	154
13.	Cytoplasmic Inheritance: The Ciliates	164
14.	Organelle Genetics: Yeast and Chlamydomonas	183
15.	Yeast Becomes a Supermodel	199
16.	The Filamentous Fungi: Eclipse and Renewal	216
17.	The Role of Biochemistry	229
18.	Genomics	238
19.	The Age of Model Organisms	250
Appendix 1.	Life Cycles and Genetic Principles	261
Appendix 2.	Macromolecules and the Central Dogma	271
Appendix 3.	Genetic Engineering	281
	Notes	285
	References	303
	Name Index	323
	Subject Index	329