The Molecular Biology of Steroid and Nuclear Hormone Receptors

by Leonard Freedman (Editor), M. Karin (Editor)

Overview

1. The Role of Heat Shock Proteins in the Regulation of Steroid Receptor Function.- 2. Subcellular and Subnuclear Trafficking of Steroid Receptors.- 3. Structure and Function of the Steroid and Nuclear Receptor Ligand-Binding Domain.- 4. Structure and Function of the Steroid and Nuclear Receptor DNA Binding Domain.- 5. Modulation of Steroid/Nuclear Receptor Dimerization and DNA Binding by Ligands.- 6. Molecular Mechanisms of Nuclear-Receptor-Mediated Transcriptional Activation and Basal Repression.- 7. Transcriptional Cross-Talk by Steroid Hormone Receptors.- 8. Chromatin and Steroid-Receptor-Mediated Transcription.- 9. Regulation of Glucocorticoid and Estrogen Receptor Activity by Phosphorylation.- 10. Monomeric Nuclear Receptors.- 11. Orphan Nuclear Receptors and Their Ligands.

Product Details

ISBN-13:	9780817639525
Publisher:	Birkhauser Verlag
Publication date:	01/01/1998
Series:	Progress in Gene Expression Series
Edition description:	New Edition
Pages:	319
Product dimensions:	6.69(w) x 9.84(h) x (d)

Table of Contents

1. The Role of Heat Shock Proteins in the Regulation of Steroid Receptor Function.- 2. Subcellular and Subnuclear Trafficking of Steroid Receptors.- 3. Structure and Function of the Steroid and Nuclear Receptor Ligand-Binding Domain.- 4. Structure and Function of the Steroid and Nuclear Receptor DNA Binding Domain.- 5. Modulation of Steroid/Nuclear Receptor Dimerization and DNA Binding by Ligands.- 6. Molecular Mechanisms of Nuclear-Receptor-Mediated Transcriptional Activation and Basal Repression.- 7. Transcriptional Cross-Talk by Steroid Hormone Receptors.- 8. Chromatin and Steroid-Receptor-Mediated Transcription.- 9. Regulation of Glucocorticoid and Estrogen Receptor Activity by Phosphorylation.- 10. Monomeric Nuclear Receptors.- 11. Orphan Nuclear Receptors and Their Ligands.

Editorial Reviews

Summarizes the latest research on the largest family of mammalian transcription factors and their roles in normal physiological functions and cancer. Takes a molecular approach, with material organized by various functions encoded in these hormone-regulated proteins, such as association with heat-shock proteins, nuclear localization, interaction with DNA, multiple roles of the ligand- binding domain, dimerization, transcriptional activation and repression, and the function of orphan receptors. Of interest to molecular biologists, endocrinologists, oncologists, and pharmacologists, as well as advanced students in these fields. Annotation c. by Book News, Inc., Portland, Or.

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