The New Mind-Body Science of Depression

by Vladimir Maletic, Charles Raison

Overview

The scientific and therapeutic implications of a new way of understanding a common disease.

Depression has often been studied, but this multifaceted disease remains far from understood. Here, leading researchers present a major new view of the disorder that synthesizes multiple lines of scientific evidence from neurobiology, mindfulness, and genetics. A comprehensive mind-body approach to understanding, evaluating, and treating this disease.

Product Details

ISBN-13:	9780393706666
Publisher:	Norton, W. W. & Company, Inc.
Publication date:	06/13/2017
Pages:	640
Product dimensions:	8.40(w) x 10.00(h) x 1.80(d)

About the Author

Vladimir Maletic, MD, is clinical professor of neuropsychiatry and behavioral science at the University of South Carolina School of Medicine and lives in Greer, South Carolina.

Charles Raison, MD, is the Mary Sue and Mike Shannon Chair for Healthy Minds, Children & Families and Professor, Human Development and Families, School of Human Ecology, and Professor, Department of Psychiatry, School of Medicine and Public Health, at the University of Wisconsin-Madison, in Madison, WI.

Table of Contents

Acknowledgments ix

Chapter 1 Does Major Depression Exist? Or, Why the Diagnostic Rule Book Is (Mostly) Wrong 1

Chapter 2 Building a New Phenomenology of Depression Where Genes and the Environment Meet 37

Chapter 3 Environmental Adversity, Loss of Evolutionary Fitness, and the Development of MDD 58

Chapter 4 The Genetics of Major Depressive Disorder 121

Chapter 5 Depression and the Brain-Body Dance: Roles of Neuroendocrine, Autonomic, and Immune Pathways 173

Chapter 6 The Immune System: Relationships with the Stress System and Major Depression 231

Chapter 7 Neuroplastic, Inflammatory, and Cellular Changes in Depression 253

Chapter 8 Functional and Structural Brain Changes in Depression 315

Chapter 9 Changes in Neurotransmission and Subcellular Function in Depression, or, The Secret of the Shogun's Box 389

Chapter 10 Pathogen Host Defense in the Evolution of Depression and Its Risk Genes 452

Chapter 11 The Case of Mary 507

Chapter 12 The Case of Anna 525

Chapter 13 The Case of Thomas 557

Index 603

Editorial Reviews

"Maletic and Raison, two obviously very experienced psychiatric clinician-scientists, have provided a provocative and well written tome highlighting the major advances that have occurred in the last decade concerning our understanding of depression and how this impacts current diagnostic procedures and treatment. They cover a vast and burgeoning area of neuroscience as it relates to mood disorders including genetics, epigenetics, inflammation, neuroendocrinology, brain imaging, and neurotransmitters. They excel in distilling complex science into readily understandable prose that will be a delight for students, patients, mental health professionals, and physicians of all subspecialties. The case reports at the end are a real bonus, both true to life and informative. It is rare for physicians and scientists to be able to write this well."

Charles B. Nemeroff

"[A] must-read for even the most skeptical of mental health professionals because it will revolutionize their understanding of major depression and mental illness altogether and provide them with ample resources to better assist their patients."

Somatic Psychotherapy Today

"Written at a somewhat post-modern moment in the history of psychiatry in which our nomenclature seems increasingly removed from therapeutics and the machinery of antidepressant drug discovery has nearly ground to a halt, The New Mind-Body Science of Depression provides a visionary synthesis of several decades of research on the depressive disorders. At over 600 pages, this is not a quick read, but it is chock full of the latest research on genetics, brain biology, neuroimmunology, and pharmacology, colored by the authors' insights gleaned from evolutionary biology. The book ends with three interesting case studies that illustrate how their synthesis can help us make a better difference in patients' lives. Maletic and Raison, widely known as master educators from their captivating talks at the US Psychiatric Congresss, show that they can write as well as they teach. You won't think about depression the same way again after reading this captivating volume!"

Michael E. Thase