The Osteoporosis Primer / Edition 1

by Janet E. Henderson, David Goltzman

Overview

Osteoporosis is one of the leading causes of morbidity and mortality among the elderly. The rationale for The Osteoporosis Primer is to provide an introductory text that relates the clinical presentation of osteoporosis to its molecular biochemical basis. The text has been organized into four sections that deal with the molecular/cellular components of bone, the development of peak bone mass, the pathophysiology of aging bone and finally, how all of these relate to the prevention, diagnosis, and treatment of osteoporosis. The international team of authors includes many leading clinicians and scientists who have provided the reader with a concise, yet comprehensive, synopsis of bone development and skeletal homeostasis. This book will be an essential introduction for individuals working on osteoporosis, including students and doctors considering a career related to metabolic bone disease, general practitioners, geriatricians, rheumatologists, and endocrinologists.

Product Details

ISBN-13:	9780521644464
Publisher:	Cambridge University Press
Publication date:	08/24/2000
Edition description:	New Edition
Pages:	388
Product dimensions:	6.93(w) x 9.72(h) x 0.91(d)

About the Author

Henderson, Janet E. (McGill Univ); Goltzman, David (McGill Univ)

Table of Contents

Preface Janet E. Henderson and David Goltzman; Part I. Molecular and Cellular Environment of Bone: 1. Endochondral bone formation and development in the axial and appendicular skeletaon A. Robin Poole, Sheila Laverty and Fackson Mwale; 2. The role of osteoblasts Jane E. Aubin; 3. Osteoclasts: characteristics and regulation of formation and activity Johan Heersche and Morris F. Manolson; 4. Bone matrix proteins Marc D. McKee and Jaro Sodek; 5. Local regulators of bone turnover Lawrence J. Fraher and Patricia H. Watson; 6. The PTH/PTHrP system and calcium homeostasis Geoffrey N. Hendy; 7. Vitamin D metabolism Marielle Gascon-Barre; 8. Sodium-dependent phosphate transport in kidney, bone and intestine Harriet S. Tenenhouse; Part II. Determinants of Peak Bone Mass: 9. Molecular genetic analysis of growth factor signalling in bone Janet E. Henderson and David Goltzman; 10. Genetic determinants of osteoporosis Milan S. Patel, Laurence A. Rubin and David E. C. Cole; 11. Non-genetic determinants of peak bone mass Velimir Matkovic and John D. Landoll; 12. Bone mineral acquisition during childhood and adolescence: physical exercise as a preventative measure Heather A. McKay and Karim M. Khan; 13. Osteoporosis in children Frank Rauch and Francis H. Glorieux; Part III. Pathophysiology of the Aging Skeleton: 14. Consequences of alterations in bone remodeling Karen Prestwood and Lawrence G. Raisz; 15. The role of parathyroid hormone and hyperparathyroidism in osteoporosis Pierre D'Amour; 16. Senile osteoporosis Patrick M. Doran and Sundeep Khosla; Part IV. Clinical Aspects of Osteoporosis; 17. Epidemiology Jaques Brown; 18. Biochemical markers of bone turnover David Hanley; 19. Radiologic assessment of osteoporosis Jaqueline C. Hodge; 20. Bone mineral density measurements Paul D. Miller and Carol Zapalowski; 21. Hormone replacement therapy Jonathan D. Adachi and Alexandra Papaioannou; 22. Selective estrogen receptor modulators Felicia Cosman and Robert Lindsay; 23. Bisphosphonate therapy of osteoporosis Fred Singer and Payam Minoofar; 24. The action of fluoride on bone Marc D. Grynpas, D. Chachra and H. Limeback; 25. PTH peptides as anabolic agents in bone Anthony B. Hodsman; 26. Vitamin D and Vitamin D analogs as therapeutic agents Richard Kremer.

Editorial Reviews

Reviewer: Elisa Ann Hofmann, BS, MD (Fox Valley Endocrinology)
Description: In this introductory text molecular, biochemical, and clinical aspects of osteoporosis are blended in four easy to read sections: the molecular and cellular bone environment, determinants of peak bone mass, pathophysiology of the aging skeleton, and clinical aspects of osteoporosis.
Purpose: By combining clinical and basic science, the editors enable a more complete understanding of the complexity of osteoporosis. They also hope that readers will gain an appreciation of the research efforts still required to make prevention of this condition a more widespread reality. The editors' objective is met since they relate, in a general way, the clinical presentation of osteoporosis to its biochemical basis. This is a refreshing change from specialized volumes on bone cell biology which serve as reference texts for those studying bone metabolism.
Audience: The intended audience includes students and doctors considering a career related to metabolic bone disease, primary care physicians, geriatricians, rheumatologists, and endocrinologists. Indeed it is written at a level appropriate to these various groups. The editors both practice academic medicine at McGill University in Montreal, Canada. The contributors include international clinicians and scientists dedicated to advancing the understanding of the pathogenesis and treatment of osteoporosis. Most contributors are affiliated with Canadian hospitals and research facilities, while the minority represent similar institutions in the U.S.
Features: The editors provide readers a comprehensive summary of bone development skeletal homeostasis and disorders of bone metabolism. In the final section contributors discuss how these processes relate to the clinical applications of biochemical markers of bone turnover, radiological assessment of osteoporosis, and the various agents used to prevent and treat osteoporosis. The figures and tables used to illustrate various bone processes and pathways are especially detailed and help facilitate understanding of the text. The references are very current, especially those used to relate clinical trials employing various pharmacologic agents used to treat osteoporosis. Moreover, the index is very complete and helpful in finding a specific topic discussed in the book.
Assessment: This primer is a useful and concise introduction to the manner in which osteoporosis relates clinically to its molecular biochemical basis. It is unlike other texts in which topics covered are solely related to the diagnosis and management of osteoporosis in more depth, such as Sartoris' Osteoporosis: Diagnosis and Treatment (Marcel Dekker, 1996). Moreover, since the focus is osteoporosis, it is also dissimilar to more broad texts in which other metabolic bone disorders are described as well, such as Favus' Primer on the Metabolic Bone Diseases and Disorders of Metabolism (Lippincott Williams & Wilkins, 1996) and Coe's Disorders of Bone and Mineral Metabolism (Lippincott Williams & Wilkins, 1992).

Doody's Review Service

"A comprehensive summary of bone development, skeletal homeostasis and disorders of bone metabolism...This primer is a useful and concise introduction to the manner in which osteoporosis relates clinically to its molecular biochemical basis." Doody's Review Service ®

"The chapters in each section are written by acknowledged experts, and in general the content and treatment are excellent. Each chapter therefore represents a useful component in a collection of reviews...for those with complete knowledge of the field who wish to extend their breadth of interest. To this end, it is a very useful contribution to the literature." New England Journal of Medicine

"...it is a very thorough text with outstanding references for each chapter. The chapters are written by scientists and clinicians who are well known in their fields...a thorough basic-science review, not only of osteoporosis but of metabolic bone disease in general. It is extremely up-to-date, with numerous references, and it will help to enhance the reader's knowledge in the very fast-moving field of osteoporosis." The Journal of Bone & Joint Surgery

"a good treattise on osteoporosis. It is also very well referenced for those who desire further information...should be well worth the purchase" Forum Jan/Feb 2002

"...a useful, easily readable text, on a topic of increasing interest." Journal of Endocrine Genetics

"..the book succeeds as an introductory text on metabolic bone disease and provides insight into the complexity of the subject without becoming overwhelming." Gerontology

From the Publisher

3 Stars from Doody

In this introductory text molecular, biochemical, and clinical aspects of osteoporosis are blended in four easy to read sections: the molecular and cellular bone environment, determinants of peak bone mass, pathophysiology of the aging skeleton, and clinical aspects of osteoporosis. By combining clinical and basic science, the editors enable a more complete understanding of the complexity of osteoporosis. They also hope that readers will gain an appreciation of the research efforts still required to make prevention of this condition a more widespread reality. The editors' objective is met since they relate, in a general way, the clinical presentation of osteoporosis to its biochemical basis. This is a refreshing change from specialized volumes on bone cell biology which serve as reference texts for those studying bone metabolism. The intended audience includes students and doctors considering a career related to metabolic bone disease, primary care physicians, geriatricians, rheumatologists, and endocrinologists. Indeed it is written at a level appropriate to these various groups. The editors both practice academic medicine at McGill University in Montreal, Canada. The contributors include international clinicians and scientists dedicated to advancing the understanding of the pathogenesis and treatment of osteoporosis. Most contributors are affiliated with Canadian hospitals and research facilities, while the minority represent similar institutions in the U.S. The editors provide readers a comprehensive summary of bone development skeletal homeostasis and disorders of bone metabolism. In the final section contributors discuss how these processes relate to the clinicalapplications of biochemical markers of bone turnover, radiological assessment of osteoporosis, and the various agents used to prevent and treat osteoporosis. The figures and tables used to illustrate various bone processes and pathways are especially detailed and help facilitate understanding of the text. The references are very current, especially those used to relate clinical trials employing various pharmacologic agents used to treat osteoporosis. Moreover, the index is very complete and helpful in finding a specific topic discussed in the book. This primer is a useful and concise introduction to the manner in which osteoporosis relates clinically to its molecular biochemical basis. It is unlike other texts in which topics covered are solely related to the diagnosis and management of osteoporosis in more depth, such as Sartoris' Osteoporosis: Diagnosis and Treatment (Marcel Dekker, 1996). Moreover, since the focus is osteoporosis, it is also dissimilar to more broad texts in which other metabolic bone disorders are described as well, such as Favus' Primer on the Metabolic Bone Diseases and Disorders of Metabolism (Lippincott Williams & Wilkins, 1996) and Coe's Disorders of Bone and Mineral Metabolism (Lippincott Williams & Wilkins, 1992).

Elisa A. Hofmann