Theoretical Immunology, Part One / Edition 1

by Alan S. Perelson

Overview

Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomena in different ways, the Sante Fe Institute and the Theoretical Division of Los Alamos National Laboratory cosponsored a workshop entitled "Theoretical Immunology". The workshop focused on themes spanning the field of immunology, with emphasis on areas where the theorists have made the most progress. This book covers the discussions a that workshop on the topics of immune surveillance, mathematical models of HIV infection, complexities of antigen-antibody systems, immune suppression and tolerance, and idiotypie networks. In each of these areas there is reason to believe that advances can be made either through interactions among experimentalists and theorists or through the critical look experimentalists and theorists will bring to bear upon one another's work.

Product Details

ISBN-13:	9780367091118
Publisher:	CRC Press
Publication date:	05/07/2019
Series:	Proceedings Volume in the Santa Fe Institute Studies in the
Pages:	428
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

Alan S. Perelson is a Staff Member of the Theoretical Biophysics Group, and an affiliate of the Center for Nonlinear Studios, University of California, Los Alamos, National Laboratory, Los Alamos, New Mexico. He received his Ph.D. in Biophysics from the University of California, Berkeley, in 1972. Perelson received the N.I.H. Research Career Development Award (1979-1984); and the Bousch Lomb Medal for Excellence in Biology. His research interests are the application of mathematics to immunological, physiological, chemical, and biophysical problems.

Table of Contents

About the Santa Fe Institute , Foreword , Cell Stimulation and Receptor Crosslinking , Desensitization, Histamine Release and the Aggregation of IgE on Human Basophils , Progress Toward Understanding the Molecular Details and Consequences of IgE-Receptor Crosslinking , Two Distinct States of Crosslinked IgE Receptors That May Trigger and Terminate Secretion from RBL-2H3 Mast Cells , A Molecular Basis For Immune Regulation: The Immunon Hypothesis , Cell-Cell Adhesion Resembles Receptor Crosslinking , B Cell Clonogenesis Induced by Anti-Immunoglobulin (Anti-lg) and Interleukins , Antigen Presentation and the Structure of Antigenic Determinants , Where Did the Macrophage Get the Antigen From? , Statistics in Immunology and Biochemistry , Hydrophilicity, Solvent Accessibility and Location of Antigenic Determinants in Proteins , Dynamics of the Immune Response , The Regulation of Lymphocyte Proliferation by Proliferating Lymphocytes: Is Lactate a Central Regulatory Element in the Immune System? , Modeling Dynamical Aspects of the Immune Response: I. T Cell Proliferation and the Effect of IL-2 , Role of Multistability in an Immune Response Model: A Combined Discrete and Continuous Approach , Systematic Approach to Modeling Immune Response , The Flow Topology of the Herzenberg Immunological Control Networks , A Logical Dynamic Systems Approach to the Regulation of Antigen-Driven Lymphocyte Stimulation , Decision Criteria and Coherence in the Regulation of the Immune Response , Antibody Affinity Distribution-Based Models for Vaccine Potency Assessment , On Immune Process Stochastic Structure , Maturation of the Immune Response , Maturation of the Immune Response Via Adaptive Walks On Affinity Landscapes , Affinity Maturation and Ecological Succession