Theoretical Immunology, Part Two / Edition 1

by Alan S. Perelson

Overview

Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomena in different ways, the Sante Fe Institute and the Theoretical Division of Los Alamos National Laboratory cosponsored a workshop entitled "Theoretical Immunology." The workshop focused on themes spanning the field of immunology, with emphasis on areas where the theorists have made the most progress. This book covers the discussions a that workshop on the topics of immune surveillance, mathematical models of HIV infection, complexities of antigen-antibody systems, immune suppression and tolerance, and idiotypie networks. In each of these areas there is reason to believe that advances can be made either through interactions among experimentalists and theorists or through the critical look experimentalists and theorists will bring to bear upon one another's work.

Product Details

ISBN-13:	9780367091132
Publisher:	CRC Press
Publication date:	05/07/2019
Series:	Theoretical Immunology , #2
Pages:	432
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

Alan S. Perelson is a Staff Member of the Theoretical Biophysics Group, and an affiliate of the Center for Nonlinear Studios, University of California, Los Alamos, National Laboratory, Los Alamos, New Mexico. He received his Ph.D. in Biophysics from the University of California, Berkeley, in 1972. Perelson received the N.I.H. Research Career Development Award (1979-1984); and the Bousch Lomb Medal for Excellence in Biology. His research interests are the application of mathematics to immunological, physiological, chemical, and biophysical problems.

Table of Contents

About the Santa Fe Institute , Santa Fe Institute Publications Committee January, 1988 , Foreword , Immune Surveillance , How Immune Cells Find Their Targets: Quantitative Studies of Cell Adhesion, Migration, and Chemotaxis , Population Dynamics of Tumors Attacked by Immunocompetent Killer Cells , Immune Surveillance: Towards a Tumor-Specific Model , Mathematical Models of HIV Infection , AIDS: Background and the Dynamics of the Decline of Immunocompetence , HIV Infection from an Ecological Viewpoint , Analysis of Immune System Retrovirus Equations , Complexities of Antigen-Antibody Systems , Models of Immunolysis Assays: A Vesicle-Based Approach for Direct Binding , Pseudo-Cooperativity Resulting from Ring Closure in Divalent Antibody—Divalent Antigen Interactions , Estimation of Antibody Affinity via Reduced-Order Modeling , Symbolic Interpretation of Data and the Definition of Factors in Immunogenetics , Immune Suppression and Self-Tolerance , Idiotypic Control of the Immune Response to Ferredoxin , Predominant Use of the Particular V Gene in the KLH-Specific Suppressor T Cell Family , The Role of l-J+ Macrophages in the Induction of Antigen B-Specific T-Suppressor Cells , Control of Lethal Autoreactivity without a Network , Idiotypic Networks , Categories of Idiotope Overlap and anti-Idiotypic Mimicry of Antigen , In Search of T-Cell Help for the Internal Image of the Antigen , Symmetry and Asymmetry in the Immune Network , Symmetric Idiotypic Networks: Connectance and Switching, Stability, and Suppression , The N-Dimensional Network , Computations in Shape Space: A New Approach to Immune Network Theory , Polydispersity in Immune Networks , Cognitive Networks: Immune, Neural, and Otherwise , Toward a Realistic Model of the Immune System