Tissue Restoration Through Regenerative Biology and Medicine

by David L. Stocum

Overview

Advances in cell, developmental and molecular biology, and the discovery of regeneration-competent cells in many non-regenerating mammalian tissues, have given impetus to systematic investigations that will enable us to regenerate these tissues by cell transplantation or the pharmaceutical induction of regeneration from the body’s own tissues. A significant avenue of research is the identification of the soluble and insoluble signals and their transduction pathways that govern the proliferation and differentiation of regeneration-competent cells, and the signals that inhibit their activity after injury.

How far can we go in our quest for regeneration? We will probably be able to induce the regeneration of some tissues, such as skin or even spinal cord, within a few years. The regeneration of others, such as heart, lung, kidney or appendages, may be more complex and difficult, but we should not view them as impossible. They will just take a little longer.

Product Details

ISBN-13:	9783540206033
Publisher:	Springer Berlin Heidelberg
Publication date:	04/14/2004
Series:	Advances in Anatomy, Embryology and Cell Biology , #176
Edition description:	Softcover reprint of the original 1st ed. 2004
Pages:	104
Product dimensions:	6.10(w) x 9.25(h) x (d)

Table of Contents

1 Introduction.- 1.1 The Biology of Regeneration.- 1.2 Regeneration of Ectodermal Derivatives.- 1.3 Regeneration of Endodermal Derivatives.- 1.4 Regeneration of Mesodermal Derivatives.- 1.5 Developmental Potential of Adult Stem Cells.- Regenerative Medicine.- 2.1 Cell Transplants.- 2.2 Chemical Induction of Regeneration In Vivo.- 3 Perspectives.- References.