Topical Drug Delivery Formulations / Edition 1

by David W. Osborne, Anton H. Amann

Overview

This book provides the pharmaceutical formulator with the fundamental understanding necessary to prepare efficacious topical drug delivery formulations that have both chemical and physical stability and that are cosmetically acceptable and preferably cosmetically elegant.

Product Details

ISBN-13:	9780824781835
Publisher:	Taylor & Francis
Publication date:	11/27/1989
Series:	Drugs and the Pharmaceutical Sciences , #42
Pages:	446
Product dimensions:	6.12(w) x 9.19(h) x (d)

About the Author

David W. Osborne, Anton H. Amann

Table of Contents

Part I: Principles of Skin and Formulation Interactions 1. Practical Considerations for Topical Drug Formulations With and Without Enhancers 2. The Importance of Epidermal Lipids for the Stratum Corneum Barrier 3. Stratum Corneum Structure and Transport Properties 4. Penetration Enhancer Incorporation in Bilayers 5. The Influence of Skin Surface Lipids on Topical Permutations 6. Immunology of the Skin Part II: Drug Formulation Selection and Testing for Topical Use 7. Computational Methods for Prodrug or Drug Analogue Selection Optimized for Percutaneous Delivery 8. Kinetic Considerations in the Design of Surfactant-Based Topical Formulations 9. The Use of Phase Behavior and Laboratory Robotics for the Optimization of Pharmaceutical Topical Formulations 10. General Considerations for Stability Testing of Topical Pharmaceutical Formulations 11. In Vitro Testing of Topical Pharmaceutical Formulations 12. Drug Delivery from Topical Formulations: Theoretical Prediction and Experimental Assessment 13. The Use of Solubility Parameters of Drug and Vehicle to Describe Skin Transport 14. Use of an Epidermal Culture for Cutaneous Toxicity Studies Part III: Nontraditional Topical Drug Delivery Formulations 15. The Microsponge: A Novel Topical Programmable Delivery System 16. Liposome-Based Vehicles for Topical Delivery 17. Surfactant Association Colloids as Topical Drug Delivery Vehicles 18. Gel Dosage Forms: Theory, Formulation, and Processing 19. Using Silicones in Topical Products