Transformation of Human Diploid Fibroblasts: Molecular and Genetic Mechanisms / Edition 1

by George E. Milo, Bruce C. Casto

Overview

This comprehensive publication draws together the important aspects of carcinogen-cell interaction. This interesting work describes the regulation of normal cell proliferation, cellular responses to carcinogen damage, the biologic consequences of cellular DNA modification, the structural and genomic changes resulting from carcinogen insult, and the possible involvement of such changes in the conversion of normal human fibroblasts to malignant cells. It presents current reviews with up-to-date literature references and provides critical information from leading investigators that is essential in understanding the biology of human cell transformation. This volume is especially useful to advanced students in genetic toxicology, molecular biologists, and all who are interested in the molecular and macromolecular changes in human cells leading to neoplasia.

Product Details

ISBN-13:	9780849349560
Publisher:	Taylor & Francis
Publication date:	05/15/1990
Pages:	304
Product dimensions:	7.00(w) x 10.00(h) x 0.70(d)

About the Author

George E. Milo, Bruce C. Casto

Table of Contents

Preface. Variations in Susceptibility to Initiation of Carcinogenesis During the Cell Cycle. Cell Cycle Regulation of DNA Repair Enzymes and Pathways. DNA Repair and Poly(ADP-ribose) Synthesis in Human Fibroblasts and Other Cell Types. Repair of O-Alkylation Damage in Human Cells. Ultraviolet Radiation-Induced Transformation of Human Cells. Biological Characterization and Quantitation of Markers of Transformation of Human Fibroblasts. Mechanisms for Cell Transformation and Carcinogenesis by Genotoxic and Nongenotoxic Agents: Role of Sodium Saccharin. Relationship Between Bulky Carcinogen-DNA Modification: Carcinogenesis and Mutagenesis. Metabolism of Polyaromatic Hydrocarbons by Human Fibroblasts. DNA Adducts and Human Cell Transformation. Cytotoxicity and Cell Culture. Mechanisms by Which Phorbol Ester Tumor Promoters Affect Gene Expression in Human Cells. Changes in Gene Expression Associated with Neoplastic Transformation of Human Fibroblasts: The Abundant Cellular Proteins. Differential Repair of Damage in Specific DNA Sequences of Human Cells. Index.

Editorial Reviews

A profile of human cell proliferation, metabolism, chemical cytotoxicity, cell transformation, molecular control of altered gene expression, repair of insult to DNA, and consequences of the modification of genomic DNA. The focus is on how metabolism and binding of metabolites to macromolecules play a role in various biological events. Also highlighted is work in site-specific modification and the differences observed in the site-directed modification of these areas and biological consequences. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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