Translational Multimodal Optical Imaging

by Fred S. Azar

Overview

Written by pioneers in the field, this first-of-its-kind resource on multimodal optical imaging provides a rigorous treatment of the various techniques together with the latest clinical advances in cancer detection and other important applications. You get full details on the principles, instrumentation, and methods of in-vivo microscopy, optical coherence tomography, endoscopy, and diffuse optical techniques. You learn how these tools can be integrated with other modalities to capture molecular, functional, and anatomical information with striking accuracy and unlock a world of potentially huge diagnostic and therapeutic benefits.

A milestone work that will speed the field's transition from bench to bedside, the book discusses each of the optical imaging techniques in self-contained chapters before describing the integration of the techniques with other modalities like MRI, X-Ray imaging, and PET imaging. It provides a software platform for multimodal integration and includes cutting-edge computational and data processing techniques that ensure the most rapid, cost-effective, and precise quantification and characterization of the clinical data possible. The volume also covers advances in photodynamic therapy and molecular imaging, and reviews key clinical studies in optical imaging along with regulatory and business issues. Supported by 119 illustrations, this first-of-its-kind volume brings you completely up to speed with today's multimodal optical techniques and helps you to translate them into viable biomedical applications.

Product Details

ISBN-13:	9781596933071
Publisher:	Artech House, Incorporated
Publication date:	09/30/2008
Pages:	400
Product dimensions:	7.20(w) x 10.20(h) x 1.10(d)

About the Author

Fred S. Azar is an external projects lead and co-principle investigator in the Department of Imaging and Visualization at Siemens Corporate Research, where he is currently developing optical imaging technologies for tracking and predicting cancer. Dr. Azar led the team which developed the first software prototype platform capable of integrating multimodal optical imaging data with X-Ray mammography and magnetic resonance images of the breast, and organized the first International Conference dedicated to optical and multimodal biomedical imaging. Dr. Azar earned his Ph.D. in bioengineering at the University of Pennsylvania and his M.S. in Bioengineering at the Ecole Centrale Paris.

Xavier Intes is assistant professor in the Department of Biomedical Engineering at Rensselaer Polytechnic Institute, Troy, NY. He has co-written more than 20 published papers in the field, and serves as a reviewer for several science and engineering journals including Applied Optics, Optics Letters, IEEE Transactions in Medical Imaging, and the Proceedings of the National Academy of Sciences. He received his Ph.D. in physics from the Universite de Bretagne Occidentale, France.

Contents. Overview of Optical Methods. In-Vivo Microscopy. Optical Coherence Tomography. Endoscopy. Diffuse Optical Techniques: Instrumentation. Diffuse Optical Techniques: Theory. Diffuse Optical Imaging for Cancer Detection. A Software Platform for Integration of Optical Imaging and Other Modalities. Optical Imaging and MRI. Optical Imaging and X-Ray Imaging. Optical Imaging and PET Imaging. Photodynamic Therapy. Building Phantoms for Optical Imaging and Multimodal Imaging. Clinical Studies in Optical Imaging: An Industry Perspective. Business and Regulations. Molecular Imaging. The Future of Optical Imaging in the Clinic: Enablers and Barriers to Entry.

Table of Contents

Overview of Optical Methods — Optical imaging technique. Optical contrast origin. In-vivo microscopy. OCT. Endoscopy. Diffuse optical techniques.

In-Vivo Microscopy — Overview of optical microscopy technique on bench. Technique applied to in-vivo. Challenge-future.

Optical Coherence Tomography — Principles. Instrumentation. Clinical applications. Challenge-future.

Endoscopy — Principles-relevance. Different methods. Clinical scenarios. Challenge-future.

Diffuse Optical Techniques: Instrumentation — Overview of different approaches. Current survey of clinical apparatus. Challenge-future.

Diffuse Optical Techniques: Theory — Diffusion equation. DOS. DOT. Assisted DOS-DOT. Challenge-future.

Diffuse Optical Imaging for Cancer Detection — Physiology. Breast cancer. Therapy monitoring. Other cancers. Challenge-future.

A Software Platform for Integration of Optical Imaging and Other Modalities — Multimodal MR/X-Ray/DOT integration. MR/DOT experimentation. DOS integration using a tracking system for handheld devices. Challenges-future.

Optical Imaging and MRI — Relevance/significance. Specific instrumentation. Specific data processing. Challenges. Challenge-future.

Optical Imaging and X-Ray Imaging — Relevance/significance. Specific instrumentation. Specific data processing. Challenges-future.

Optical Imaging and PET Imaging — Relevance/significance. Specific instrumentation. Specific data processing. Challenges. Future.

Photodynamic Therapy — Principles. Instrumentation. Clinical Applications. Challenges-future.

Building Phantoms for Optical Imaging and Multimodal Imaging — Relevance/significance. Methods. Challenges. Future.

Clinical Studies in Optical Imaging: An Industry Perspective — Relevance/significance. Methods. Challenges. Future.

Business and Regulations — Business case. ISO regulations. FDA regulations. Defining standard as a community. Validating an optical system in clinical trials. Challenge-future.

Molecular Imaging — Relevance/significance. Actual exogenous agent used in clinical settings. Pre-clinical work. Challenge-future.

The Future of Optical Imaging in the Clinic: Enablers and Barriers to Entry