Table of Contents
Frontmatter — Preface — Contents — List of Contributors — Significant Steps in the Discovery and Application of Pteridines — Specific Inhibition of Dihydrofolate Biosynthesis - A New Approach to Chemotherapy — Mammalian Dihydrofolate Reductase: Porcine Liver Enzyme — Kinetic Studies of Escherichia Coli Dihydropteroate Synthetase — Dihydropteroate Synthase: Purification by Affinity Chromatography and Mechanism of Action — The Properties of Gamma Glutamyl Hydrolase (Conjugase) from Bovine Liver — The Purification of Riboflavin Synthetase by Affinity Chromatography Using 7-Oxolumazines — Interaction of Riboflavin Synthetase with Analogues of 6,7-Dimethyl-8-Ribityllumazine — Structure-Activity Relationship Among Pteridine Derivatives and Related Quinazolines as Inhibitors of Dihydrofolate Reductases — Spectral Studies of Thymidylate Synthetase — Four Folate Metabolizing Enzymes of Mouse Embryo Fibroblasts and L-Cells as Tested During the Culture Cycle — The Activity of the Cobalamine-dependent Methionine- Synthetase (5-Methyl-5, 6, 7, 8-Tetrahydrofolic Acid: Homocysteine Methyltransferase) in Rapidly Growing Human Cells and the Effect of Some Folic Acid Derivatives and Analogues — The Role of Folate Binding Proteins in Folate Metabolism — Transport of Folate Compounds into Mammalian and Bacterial Cells — Transport of Folate Compounds through the Membrane of Human Lymphoblastoid Cells — The Characterization of High Molecular Weight Complexes of Folic Acid in Mammalian Tissues — The Enzymic Synthesis of Pterins in Escherichia Coli — Biosynthesis of Pterins in Mammalian Systems — The Synthesis of Pterins Catalyzed by Enzymes from Drosophila melanogaster — Biosynthesis of Biopterin in the Intact Rat and in Mouse Neuroblastoma Cells — Studies on the Biosynthesis of Riboflavin — Studies on the Mechanism of Phenylalanine Hydroxylase: Detection of an Intermediate — Effect of Pteridine Cofactor Structure on the Regulation of Phenylalanine Hydroxylase Activity — Interrelationships between C-1 Metabolism and Photosynthesis in Euglena Gracilis — Folate Derivatives and Patterns of C-1 Metabolism in Neurospora Crassa, Wild Type, Ser-1 and Formate Mutants — The Biosynthesis of Folic Acid and Pteridine Cofactor (s) and its Regulation — Reduced Pterins as Possible Mediators in Cellular Electron Transfer — The Handling and Metabolism of Folates in the Rat and Man, with Especial Relationship to Disease — Red Blood Cell Polyglutamyl Folates in Vitamin B12 Deficiency — Novel Urinary Metabolites of Folic Acid in the Rat — "Prune"/"Killer-of-Prune": A Complementary Lethal System in Drosophila Melanogaster Affecting Pteridine Metabolism — Kynurenine as Trigger in Pterorhodin Synthesis in Ephestia Kuhniella Z. — Growth Stimulation by 6-Phenacylisoxanthopterin and Related Compounds — The Possible Role in Gene Regulation of an Isoxanthopterinbinding Protein from Oncopeltus Embryos — Poly-?-Glutamyl Chain Lengths in some Natural Folates and Contributions of Folic Acid Synthesized by Intestinal Microflora to Rat Nutrition — Tissue-Specific Synthesis of Methotrexate Polyglutamates in the Rat — A Convenient Synthesis of Methotrexate and Related Compounds — Methods for the Synthesis of Folic Acid Analogs, Substituted Folic Acid Analogs, Folic Acid and Folic Acid Conjugates — New Folate Analogs: Alterations in the C9-N10 Region — The Synthesis and Study of 10-Thia-10-Deaza-Analogs of Pteroic Acid, Folic Acid, and of Related Compounds: The Problem of Racemization in the Cyclization of Substituted 2-Amino-3-Cyanopyrazines — Synthesis and Properties of 5-Methyldihydrofolate — A Coloured Oxidation Product from Tetrahydrofolate — Pteridine Synthesis — The 7-Azapteridines — Enzymatic Oxidation of Pteridin-4-ones and Related Compounds — Synthesis and Structure of Dihydro- and Tetrahydroderivatives of Pterin 6,7-Dicarboxylic Acid — Direct Conversion of 4-Hydroxypteridines to their 4-Amino Analogs — High Pressure Liquid C
