Uremic Toxins and Organ Failure

by Hideyuki Saito (Editor), Takaaki Abe (Editor)

Overview

This book describes the latest research on the gut-kidney axis of ureic solutes; the toxico-pathological mechanisms of uremic toxin-induced organ failure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies for uremia and related organ failure associated with kidney injuries and diseases. Retained uremic toxins cause a variety of symptoms, such as hypertension, fatigue, renal anemia, osteoporosis and neurologic impairment, which are apparent in chronic kidney disease (CKD) patients. The human gastrointestinal tract contains trillions of microorganisms, referred to as gut microbiota, which support the host metabolism by producing nutrients, such as vitamins and short-chain fatty acids. However, they also produce various harmful uremic toxins that show renal and cardiovascular toxicity, and correlate with an increased mortality in CKD patients. The composition and balance of gut microbiota are associated with the accumulation of uremic toxins and the pathophysiology of CKD, and as such are being considered for a novel therapeutic strategy.

Product Details

ISBN-13:	9789811577932
Publisher:	Springer-Verlag New York, LLC
Publication date:	10/12/2020
Sold by:	Barnes & Noble
Format:	eBook
File size:	17 MB
Note:	This product may take a few minutes to download.

About the Author

Hideyuki Saito

Department of Pharmacy, Kumamoto University Hospital&Department of Clinical Pharmaceutical Sciences, Kumamoto University Graduate School of Life Sciences, Kumamoto University

Honjo, Chuo-ku, Kumamoto, Japan

Email: [e-mail]

 

Takaaki Abe

Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine

Tohoku University Graduate School of Medicine

Seiryo-cho, Aoba-ku, Sendai, Japan

Email: [e-mail]

Table of Contents

1 Overview of Uremic Toxins.- 2 Review: Uremic toxins and gut microbiome.- 3 Gut microbiota and systemic uremic solute accumulation.- 4 Uremic toxin-related systemic disorders.- 5 Uremic Toxins and cardiovascular disease.- 6 Indoxyl sulfate and arteriosclerosis.- 7 Uremic Toxicity and Bone in CKD.- 8 D-serine as a novel uremic toxin.- 9 Uremic solutes and sarcopenia.- 10 Toxico-pathological role of hepatic sulfotransferase (SULT) 1A1 in acute kidney injuries.- 11 Accumulation of uremic toxins in systemic organs and the effect of AST-120.

Editorial Reviews

Reviewer: Jon Webb, MD (University of Kentucky College of Medicine)
Description: This book aims to highlight important toxic metabolites that are retained in kidney failure and lead to various organ disorders. The chapters are a collection of studies that discuss the origin, chemical entity, and composition of the retained uremic solutes responsible for diseases.
Purpose: The expected outcome of these chapters is to increase awareness of uremic toxins that accumulate in various stages of acute kidney and chronic kidney disease. The book hopes to serve as the foundation for discovery and development of effective treatments for preventing toxic effects of these uremic toxins. A better understanding of these waste products is helpful for the future care of an increasingly growing population of patients.
Audience: The book will be useful for students, trainees, and providers of patients with advanced kidney disease. However, the text may be most helpful for those researchers, either lab or clinical, interested in the development of novel approaches to treating the consequences of uremic toxin accumulation. The authors are leaders in the field and provide expert information.
Features: In this book, state-of-the-art reviews, including an overview of uremic toxins, gut-kidney axis, uremic toxin-related organ failure, and preventative strategies for reduction of uremic toxins, are summarized. Eleven chapters by experts in the field are included. The chapters begin with an abstract, include well-defined sections, and conclude with summary statements and extensive references. Although images are limited, they are colorful and add to the text. The book would be enhanced with highlighted learning points and future directions.
Assessment: This book provides an important reference for those involved in the care of patients with kidney disease. The book will provide an important foundation for future research and development of strategies to better care for a growing population of patients suffering from the consequence of uremic toxin retention. I recommend this book especially for those involved in kidney disease research.

Doody's Review Service